Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Nuclear magnetic resonance (NMR) of molecules and cells in media with 'tunable' anisotropy: high rank-spins, z-spectra, (pro)chiral discrimination, peptide L-to-D isomerase. This project will build on this team's invention of a stretched-gel method that reports on molecular composition and the geometrical arrangement of atoms into mirror image arrays, using nuclear magnetic resonance spectroscopy. The project will use the methodology to determine roles of a platypus venom enzyme that carries out ....Nuclear magnetic resonance (NMR) of molecules and cells in media with 'tunable' anisotropy: high rank-spins, z-spectra, (pro)chiral discrimination, peptide L-to-D isomerase. This project will build on this team's invention of a stretched-gel method that reports on molecular composition and the geometrical arrangement of atoms into mirror image arrays, using nuclear magnetic resonance spectroscopy. The project will use the methodology to determine roles of a platypus venom enzyme that carries out stereoscopic interconversions, even in humans.Read moreRead less