Mobility of water in cartilage as a probe of molecular structure and function. Clinical diagnosis of early-stage osteoarthritis is difficult, and most patients are not diagnosed until a substantial degradation of cartilage has occurred as a result of the disease. This research will study the interaction between different components of articular cartilage and investigate, how this interaction can be exploited for the development of reliable and non-invasive techniques of cartilage imaging. Mobili ....Mobility of water in cartilage as a probe of molecular structure and function. Clinical diagnosis of early-stage osteoarthritis is difficult, and most patients are not diagnosed until a substantial degradation of cartilage has occurred as a result of the disease. This research will study the interaction between different components of articular cartilage and investigate, how this interaction can be exploited for the development of reliable and non-invasive techniques of cartilage imaging. Mobility of water molecules is a potent indicator of the microscopic structure of the cartilage scaffold. We will use this fundamental biophysical relationship to measure the internal architecture of collagen fibres; observe the changes effected by mechanical load; and distinguish between healthy and osteoarthritic cartilage.
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From dust to planets: New initiatives to refine models of the inner Solar System's earliest history. This project will help continue the proud tradition of Australia as an international leader in mass spectrometric analyses and cosmochemistry. The questions surrounding the origin and significance of terrestrial planets are closely related to our very presence: "Are we alone"?
Research into meteorites is one of the few areas of science that truly captures the imagination of the general public. T ....From dust to planets: New initiatives to refine models of the inner Solar System's earliest history. This project will help continue the proud tradition of Australia as an international leader in mass spectrometric analyses and cosmochemistry. The questions surrounding the origin and significance of terrestrial planets are closely related to our very presence: "Are we alone"?
Research into meteorites is one of the few areas of science that truly captures the imagination of the general public. This project, through its integration with the WA Museum, gives the public a possibility to share in this experience.Read moreRead less
From structures to systems: A hierachical approach to understanding sub-cellular components. This program will dramatically extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Au ....From structures to systems: A hierachical approach to understanding sub-cellular components. This program will dramatically extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation techniques in biomolecular systems, which are widely used within the chemical and pharmaceutical industries for modelling processes ranging from protein-drug interactions to the phase behaviour of lipids and surfactants. Read moreRead less
Spin-liquids, antiferromagnetism, and superconductivity in organic charge transfer salts: synthesis, neutron scattering and theory. Materials have driven the digital revolution. Understanding and controlling silicon has allowed us to make smaller devices that perform better; an iPhone has more computing power than a PC had ten years ago. For this remarkable trend to continue future devices will need to utilise novel physics and be made from new materials. We will grow crystals of organic molecul ....Spin-liquids, antiferromagnetism, and superconductivity in organic charge transfer salts: synthesis, neutron scattering and theory. Materials have driven the digital revolution. Understanding and controlling silicon has allowed us to make smaller devices that perform better; an iPhone has more computing power than a PC had ten years ago. For this remarkable trend to continue future devices will need to utilise novel physics and be made from new materials. We will grow crystals of organic molecules, whose properties derive from the correlated motion of the electrons in these materials. State-of-the-art 'neutron scattering' experiments will test theories of the way the electrons behave in these materials. We will answer fundamental questions, which is an important first step towards harnessing such effects for future technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100064
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A facility for sensitive and precise isotopic dating of the earth's and extraterrestrial rocks. SPIDE2R will be a new generation mass spectrometer for very precise and sensitive dating and forensics applications in earth and planetary sciences, hydrology, climate studies, and nuclear and archaeological fingerprinting. The unprecedented sensitivity of this unique instrument will provide enhanced capabilities for solving long-standing problems requiring precise geological time resolution, as well ....A facility for sensitive and precise isotopic dating of the earth's and extraterrestrial rocks. SPIDE2R will be a new generation mass spectrometer for very precise and sensitive dating and forensics applications in earth and planetary sciences, hydrology, climate studies, and nuclear and archaeological fingerprinting. The unprecedented sensitivity of this unique instrument will provide enhanced capabilities for solving long-standing problems requiring precise geological time resolution, as well as opening new areas of research. It will be the instrument of choice for analysing small, rare samples such as those returned by space missions. The Australian-built high sensitivity source and ion detection systems can be retrofitted onto other mass spectrometers, opening a new area of commercialisation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346515
Funder
Australian Research Council
Funding Amount
$507,000.00
Summary
Fluorescence Detector for the Australian National Beamline Facility. X-ray absorption spectroscopy (XAS) is an extremely important synchrotron radiation tool for determining the local structure around an X-ray absorbing atom. This has many applications in the study of materials, minerals, metal complexes, and metalloproteins and can often be used to obtain information that is not available by other techniques, because structural information can be obtained in the solid or solution state and in ....Fluorescence Detector for the Australian National Beamline Facility. X-ray absorption spectroscopy (XAS) is an extremely important synchrotron radiation tool for determining the local structure around an X-ray absorbing atom. This has many applications in the study of materials, minerals, metal complexes, and metalloproteins and can often be used to obtain information that is not available by other techniques, because structural information can be obtained in the solid or solution state and in mixtures. The current proposal is aimed at introducing new technology into the Australian National Beamline Facility that will greatly improve the quality and quantity of experiments that can be performed and extend studies into dilute solutions and protein samples.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100081
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The pr ....Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The proposed facility will provide significant benefits to Australian researchers in drug design and delivery, nano-material design and characterisation at nano scale for advanced materials, and promotion of renewable energy. This represents a great opportunity to make discoveries and breakthroughs in frontier science and technology in Australia.Read moreRead less
Special Research Initiatives - Grant ID: SR0354751
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Bio-Metals Research Network. The aim of the Bio-Metals Research Network is to connect the extensive Australian expertise in the study of metal ions in relation to the Environment, Health and Frontier Technologies. The Network is inter-disciplinary and brings together over 50 group leaders in the biological, biomedical and physical sciences. A major aim of the Network will be to provide a molecular understanding of biological and environmental processes and disease states as well as pr ....Australian Bio-Metals Research Network. The aim of the Bio-Metals Research Network is to connect the extensive Australian expertise in the study of metal ions in relation to the Environment, Health and Frontier Technologies. The Network is inter-disciplinary and brings together over 50 group leaders in the biological, biomedical and physical sciences. A major aim of the Network will be to provide a molecular understanding of biological and environmental processes and disease states as well as providing new materials for the development of new technologies. The Network will interact in research and education with Bio-Metals groups around the world and will develop collaborative funding proposalsRead moreRead less
Fluctuations in the properties of nonequilibrium fluids and the influence of thermostatting mechanisms. The behaviour of nonequilibrium fluids will be studied by combining ideas from liquid state theory, statistical mechanics and dynamical systems theory. This work will result in development and testing of mathematical expressions (Fluctuation Theorems) that are consistent with the Second Law of Thermodynamics, which determines the direction of any change in any macroscopic system, but are also ....Fluctuations in the properties of nonequilibrium fluids and the influence of thermostatting mechanisms. The behaviour of nonequilibrium fluids will be studied by combining ideas from liquid state theory, statistical mechanics and dynamical systems theory. This work will result in development and testing of mathematical expressions (Fluctuation Theorems) that are consistent with the Second Law of Thermodynamics, which determines the direction of any change in any macroscopic system, but are also applicable to microscopic systems. The expressions will determine the probability that finite sized systems will violate the Second Law for small periods of time and will therefore contribute to development of a fundamental understanding of microscopic systems and the development of nanotechnology.
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Dendrimers: multidimensional sensors. The threat of terrorism is presented to us on a daily basis. Although there is often talk of dirty bombs, and biological and nuclear terrorism, the most easily sourced weapon of the terrorist is still the conventional explosive. As such the ability to detect trace amounts of compounds such as TNT or Semtex is required. This means that there is a real need for a portable detection system with the ability to reliably sense a specific explosive, selectively at ....Dendrimers: multidimensional sensors. The threat of terrorism is presented to us on a daily basis. Although there is often talk of dirty bombs, and biological and nuclear terrorism, the most easily sourced weapon of the terrorist is still the conventional explosive. As such the ability to detect trace amounts of compounds such as TNT or Semtex is required. This means that there is a real need for a portable detection system with the ability to reliably sense a specific explosive, selectively at low concentrations. This project concerns the development of new sensors that have potential to increase the nation's security.Read moreRead less