Discovery Early Career Researcher Award - Grant ID: DE170100068
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This pr ....Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This project aims to harness cells’ exquisite biological properties to improve current detection techniques. It will integrate liposome-based sensors with microfluidics to perform analytical tasks ranging from food safety to diagnostics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100155
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Magnetic biosensing: developing high frequency spintronic sensors for magnetic label detection. This project builds upon recent advances in nano-magnetism to develop novel, miniaturised, electronic biosensors. Such biosensors will one day enable the production of portable devices for rapid, on-site detection of cancer and other diseases, thereby reducing reliance on costly laboratory based analyses and improving remote and rural healthcare.
Discovery Early Career Researcher Award - Grant ID: DE150101655
Funder
Australian Research Council
Funding Amount
$297,036.00
Summary
Discriminative detection and quantification of cancer imaging biomarkers. This project aims to develop a new framework for the detection and quantification of cancer biomarkers in diagnostic and histopathology images with discriminative modelling of intrinsic structures. The framework will be the first computerised solution to provide automated, quantitative annotations of cancer imaging biomarkers at the macroscopic and microscopic levels to support standardised reporting of image interpretatio ....Discriminative detection and quantification of cancer imaging biomarkers. This project aims to develop a new framework for the detection and quantification of cancer biomarkers in diagnostic and histopathology images with discriminative modelling of intrinsic structures. The framework will be the first computerised solution to provide automated, quantitative annotations of cancer imaging biomarkers at the macroscopic and microscopic levels to support standardised reporting of image interpretation. It will help to alleviate the inter-observer variability and time-consuming process of manual analysis. The project aims to advance fundamental biomedical imaging research in generalised visual structure extraction and classification, and enable large-scale translational research in systems pathology for personalised cancer care.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102352
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Three-dimensional structural imaging in optical microscopy and tomography. This project will develop fundamentally new strategies for looking inside live cells to determine their internal structures. Such capability will permit a better understanding of diseases, the link between diabetes and heart failure for example, opening the door for new diagnostic techniques and treatments.
Discovery Early Career Researcher Award - Grant ID: DE130101033
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
An ultrafast mid-infrared fiber laser: short pulses at long wavelengths. This project will result in the creation of a unique laser system, operating in the mid-infrared wavelength range and generating short bursts of light, which will have a potentially revolutionary impact in many areas of physics, health, defence and astronomy.
Discovery Early Career Researcher Award - Grant ID: DE210101137
Funder
Australian Research Council
Funding Amount
$458,665.00
Summary
Exploiting biological noise for next generation electrochemical biosensors. This project aims to harness the intrinsic noise in a biological system to develop a new platform for biosensors. This will lead to advancement of a new versatile electrochemical platform for real-time screening with vast applications that span from sensing at sub-cellular level to point-of-care and implantable biosensors. The new sensory technique will improve the specificity, sensitivity and resolution in biosensors an ....Exploiting biological noise for next generation electrochemical biosensors. This project aims to harness the intrinsic noise in a biological system to develop a new platform for biosensors. This will lead to advancement of a new versatile electrochemical platform for real-time screening with vast applications that span from sensing at sub-cellular level to point-of-care and implantable biosensors. The new sensory technique will improve the specificity, sensitivity and resolution in biosensors and enables measurement of multiple biomarkers simultaneously in real-time. The outcomes will contribute to a better understanding of fundamental physiological processes and chemical interactions at subcellular level which will inform future advancements in biomedical engineering.
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Discovery Early Career Researcher Award - Grant ID: DE220100846
Funder
Australian Research Council
Funding Amount
$418,388.00
Summary
Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a ne ....Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a new strategy to brighten the upconversion nanomaterials. This project should push upconversion nanoscience to a new generation and provide significant benefits in ultra-sensitive biomolecular assays and in vivo bioimaging.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100413
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Neurobiology of parenting and disruptive behaviour disorders in childhood. This project aims to examine the genetic determinants and contribution of parenting to childhood disruptive behaviour disorders. These disorders are often chronic and associated with comorbid conditions in later life, creating enormous personal and social costs for individuals and families, and a burden on the economy. About a third of children do not respond to current forms of early intervention, so clinicians need evid ....Neurobiology of parenting and disruptive behaviour disorders in childhood. This project aims to examine the genetic determinants and contribution of parenting to childhood disruptive behaviour disorders. These disorders are often chronic and associated with comorbid conditions in later life, creating enormous personal and social costs for individuals and families, and a burden on the economy. About a third of children do not respond to current forms of early intervention, so clinicians need evidence of the interaction between parenting practices and the developmental aspects of these disorders This project will examine oxytocin genetics in toddlers with disruptive behaviour disorders and their parents, to ultimately identify the genetic, family, and developmental processes that shape persistent disorders.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102503
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical sam ....Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical samples.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100569
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Ultra-Porous Devices by Synergistic Aerosol and Atomic Layer Depositions. The project aspires to develop a scalable low-cost approach for the synthesis and integration of ultra-porous films in nanodevices. The project intends to deposit atomic layers onto aerogel-like nanoparticle networks, self-assembled by thermophoresis of flame-made aerosols. This would increase the atomically-deposited layer mass by several hundred-fold per cycle and result in ultra-porous films with electrochemically activ ....Ultra-Porous Devices by Synergistic Aerosol and Atomic Layer Depositions. The project aspires to develop a scalable low-cost approach for the synthesis and integration of ultra-porous films in nanodevices. The project intends to deposit atomic layers onto aerogel-like nanoparticle networks, self-assembled by thermophoresis of flame-made aerosols. This would increase the atomically-deposited layer mass by several hundred-fold per cycle and result in ultra-porous films with electrochemically active surface areas. It is intended that the project will demonstrate the fabrication of solid–gas, solid–liquid and solid–solid nanointerfaces, which will be applicable to key emerging technologies such as wearable medical diagnostics.Read moreRead less