Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100042
Funder
Australian Research Council
Funding Amount
$462,846.00
Summary
Developing a multimodal imaging pipeline for antisense technology. Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules a ....Developing a multimodal imaging pipeline for antisense technology. Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules across cells and tissues and refined imaging methods. This project should provide more strategic delivery of antisense molecules to specific cells and tissue, which will have significant downstream economic and social benefits to the Australian community. Read moreRead less
Unlocking the mechanisms of vibro-acoustic communication in termites . Our understanding of how termites use microvibrations to communicate is limited, as the generation, transmission and detection of these complex vibrations in substrates at the submillimetre scale are unknown. We aim to develop a fully validated vibro-acoustic termite communication model which will be used in Swårmalätørs to demonstrate their ability to synchronise and mimic collective behaviour. This will be achieved by combi ....Unlocking the mechanisms of vibro-acoustic communication in termites . Our understanding of how termites use microvibrations to communicate is limited, as the generation, transmission and detection of these complex vibrations in substrates at the submillimetre scale are unknown. We aim to develop a fully validated vibro-acoustic termite communication model which will be used in Swårmalätørs to demonstrate their ability to synchronise and mimic collective behaviour. This will be achieved by combining novel acoustic levitation, microsystem analyses and electrophysiology to determine physical properties of termite appendages, sensory and behavioural thresholds; and by considering wave transmission characteristics in wood, friction-adhesion at the termite feet, mandible cutting and soldier alarm drumming.Read moreRead less