Iron accumulation in the nematode C.elegans: a model of ageing. This project will investigate the role of biological metals in the process of ageing, the causes of which remain unresolved. The practical outcomes for society are broad; beyond improving understandings of the basic biology of ageing, this study will provide new insight and approaches that can be used to optimise lifespan.
Neural plasticity in older adult human vision. This project aims to expand our understanding of age related changes in brain function, specifically plasticity. The project will increase knowledge of the role of an inhibitory neurotransmitter GABA in visual plasticity. Expected outcomes include new knowledge regarding the regulation of brain function in adulthood, enabling future research and planning for societal benefit to older Australia.
Discovery Early Career Researcher Award - Grant ID: DE140100162
Funder
Australian Research Council
Funding Amount
$374,005.00
Summary
Enzymatic synthesis of pro-resolution lipid mediators: Towards new therapeutic strategies for inflammatory diseases. Inflammation is a major contributing factor in many diseases, including arthritis, Alzheimer's disease, multiple sclerosis, cardiovascular disease and cancer. It has recently been shown that the resolution of inflammation is an active biological process initiated by lipid mediators. The aim of this project is to synthesise and characterise pro-resolution lipid mediators, elucidate ....Enzymatic synthesis of pro-resolution lipid mediators: Towards new therapeutic strategies for inflammatory diseases. Inflammation is a major contributing factor in many diseases, including arthritis, Alzheimer's disease, multiple sclerosis, cardiovascular disease and cancer. It has recently been shown that the resolution of inflammation is an active biological process initiated by lipid mediators. The aim of this project is to synthesise and characterise pro-resolution lipid mediators, elucidate the enzyme cascades involved in their biosynthesis and explore their roles in the active resolution of inflammation. This project will provide a fundamental understanding of pro-resolution and anti-inflammatory pathways as well as new therapeutic target molecules for the treatment of inflammatory diseases.Read moreRead less
ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for ....ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for and make better decisions for an ageing world, with consequent social and economic benefits for families and communities expected to flow to Australia, the Asian region and the world.Read moreRead less
Amplifying Voices from the Royal Commission into Aged Care. The Royal Commission into Aged Care Quality and Safety is a singular opportunity to reform Australian aged care and redress the marginalisation of aged care residents—a vulnerable demographic whose voices too often go unheard. Using innovative arts-based forms of storytelling, this project explores how non-traditional approaches can provide older Australians with more visibility in aged care policy debates. Combining media analysis with ....Amplifying Voices from the Royal Commission into Aged Care. The Royal Commission into Aged Care Quality and Safety is a singular opportunity to reform Australian aged care and redress the marginalisation of aged care residents—a vulnerable demographic whose voices too often go unheard. Using innovative arts-based forms of storytelling, this project explores how non-traditional approaches can provide older Australians with more visibility in aged care policy debates. Combining media analysis with poetic inquiry, participatory photography, citizen storytelling, and interactive art, this project amplifies the voices of residents and engages policy makers, providers, and the public in a reflexive, inclusive conversation about the past, present and future of aged care. Read moreRead less
Integrated depression management: a trial of a new model of care in a low vision rehabilitation setting. The project will integrate depression management into Vision Australia services and evaluate the impact of this new model of care. We anticipate that this new approach will lead to sustained improvements in clients’ quality of life.
Sexual well-being and ageing: a study of older Australian women. This research addresses important issues of ageism and sexism that together affect older women's health and well-being. The findings will inform the link between aging, sexuality and more general dimensions of health and well-being and advance our understanding of issues central to policy and services for older Australians.
Vulnerability and resilience in Indonesian women suffering from cancer. This project aims to investigate the social processes shaping middle-aged women’s vulnerability and resilience to cervical cancer in Indonesia. This project will generate a new interdisciplinary approach to investigating how different factors such as age, socioeconomic status and gender intersect to influence women’s vulnerability across their life course. The project will provide significant research training for Australian ....Vulnerability and resilience in Indonesian women suffering from cancer. This project aims to investigate the social processes shaping middle-aged women’s vulnerability and resilience to cervical cancer in Indonesia. This project will generate a new interdisciplinary approach to investigating how different factors such as age, socioeconomic status and gender intersect to influence women’s vulnerability across their life course. The project will provide significant research training for Australians and Indonesians, extensive international collaboration, and a better understanding of how to reduce health disparities among vulnerable groups.Read moreRead less
Designing liveable neighbourhoods to support healthy ageing. This project aims to identify whether neighbourhood liveability influences healthy ageing, and the extent to which this association is modified by individual preferences and socioeconomic disadvantage using longitudinal analyses. The research expects to generate new knowledge on urban design that supports healthy ageing, which is mostly derived from cross-sectional studies. Expected outcomes include evidence-based recommendations for i ....Designing liveable neighbourhoods to support healthy ageing. This project aims to identify whether neighbourhood liveability influences healthy ageing, and the extent to which this association is modified by individual preferences and socioeconomic disadvantage using longitudinal analyses. The research expects to generate new knowledge on urban design that supports healthy ageing, which is mostly derived from cross-sectional studies. Expected outcomes include evidence-based recommendations for informing urban design and health policies to support healthy ageing and ageing in place, which is a key government agenda in Australia. This should provide benefits such as the delivery of high quality liveable environments that support healthy ageing and reduced aged care expenditure.Read moreRead less
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.