Discovery Early Career Researcher Award - Grant ID: DE140100162
Funder
Australian Research Council
Funding Amount
$374,005.00
Summary
Enzymatic synthesis of pro-resolution lipid mediators: Towards new therapeutic strategies for inflammatory diseases. Inflammation is a major contributing factor in many diseases, including arthritis, Alzheimer's disease, multiple sclerosis, cardiovascular disease and cancer. It has recently been shown that the resolution of inflammation is an active biological process initiated by lipid mediators. The aim of this project is to synthesise and characterise pro-resolution lipid mediators, elucidate ....Enzymatic synthesis of pro-resolution lipid mediators: Towards new therapeutic strategies for inflammatory diseases. Inflammation is a major contributing factor in many diseases, including arthritis, Alzheimer's disease, multiple sclerosis, cardiovascular disease and cancer. It has recently been shown that the resolution of inflammation is an active biological process initiated by lipid mediators. The aim of this project is to synthesise and characterise pro-resolution lipid mediators, elucidate the enzyme cascades involved in their biosynthesis and explore their roles in the active resolution of inflammation. This project will provide a fundamental understanding of pro-resolution and anti-inflammatory pathways as well as new therapeutic target molecules for the treatment of inflammatory diseases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101514
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations ....The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations are controlled. Understanding neuroplasticity is vital for learning, memory and healthy ageing throughout life.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100729
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Brain connectivity during movement planning and execution in young and older adults. Ageing is associated with a reduced ability to undertake everyday movement tasks, resulting in loss of independence and frequent injuries due to falls. This research will improve our understanding of the brain mechanisms underlying movement control, with the aim of maintaining older people's quality of life and reducing health costs to the nation.
Discovery Early Career Researcher Award - Grant ID: DE220100185
Funder
Australian Research Council
Funding Amount
$438,712.00
Summary
Decoding the evolution of killer T cell immunity across human lifetime. The immune system is a potent weapon for protection against pathogens. T cells have a central role as their receptors monitor the body for threats. The thymus (organ) educates receptors to discriminate between healthy and infected cells. Receptor diversity and T cell strength change throughout human life. This project aims to unravel how T cells gain and lose optimal receptors and strength. The aims are to understand 1) The ....Decoding the evolution of killer T cell immunity across human lifetime. The immune system is a potent weapon for protection against pathogens. T cells have a central role as their receptors monitor the body for threats. The thymus (organ) educates receptors to discriminate between healthy and infected cells. Receptor diversity and T cell strength change throughout human life. This project aims to unravel how T cells gain and lose optimal receptors and strength. The aims are to understand 1) The role of thymic education in diversifying receptors 2) Whether gradual loss of thymic education affects receptor diversity 3) The molecular mechanisms underlying T cell strength. The project is essential for understanding how optimal T cell immunity is formed, critical if we wish to harness this to improve healthy aging.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100771
Funder
Australian Research Council
Funding Amount
$278,780.00
Summary
Automated system for bone texture analysis of osteoarthritis in hand radiographs. Early detection and prediction of hand osteoarthritis are not feasible by current methods of visual grading of hand radiographs. This project will develop a novel, fully automated system for selection of bone texture regions on hand radiographs and their analysis to address this problem.
Discovery Early Career Researcher Award - Grant ID: DE120100434
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Estrogen-mediated regulation of gene expression via transcriptional and translational control: complementary, synergistic or opposing responses? Hormones dictate cellular behaviour by activating pre-programmed responses. The sex hormone estrogen affects cell fate by regulating the gene expression, but it is unknown to which extent this response occurs via activation of genes or control of already transcribed gene. The project will investigate how the cell integrates the complex estrogen signals.
Discovery Early Career Researcher Award - Grant ID: DE150101180
Funder
Australian Research Council
Funding Amount
$362,000.00
Summary
The neuroethics of cognitive ageing. As the workforce ages, Australian and international governments are prioritising brain health, seeking to increase economic productivity and reduce the costs of age-related cognitive decline. In addition to healthy lifestyle habits, certain neurotechnologies are being promoted as the means to protect cognitive performance. This project aims to explore the ethical issues and social pressures that ageing individuals experience as a result of cognitive ageing. U ....The neuroethics of cognitive ageing. As the workforce ages, Australian and international governments are prioritising brain health, seeking to increase economic productivity and reduce the costs of age-related cognitive decline. In addition to healthy lifestyle habits, certain neurotechnologies are being promoted as the means to protect cognitive performance. This project aims to explore the ethical issues and social pressures that ageing individuals experience as a result of cognitive ageing. Understanding later life from the perspective of ageing individuals may enable society to meet the ethical and policy challenges raised by emphasising cognitive wellbeing above other aspects in the ageing process.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100825
Funder
Australian Research Council
Funding Amount
$422,955.00
Summary
Functional insights into the roles of enteric glia. This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor ex ....Functional insights into the roles of enteric glia. This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor expression in the primate colon. Expected outcomes include a detailed map of enteric glia and definitions of their basic biology. This project builds on the techniques and collaborations made by the candidate over recent years. This will benefit our basic understanding of enteric glia biology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100406
Funder
Australian Research Council
Funding Amount
$375,936.00
Summary
Cognitive Compensation in Ageing. Decline in cognitive control can have a devastating effect on an individual's capacity to live a high quality and safe independent life. It is an untested assumption that older adults can compensate for age-related changes in cognitive control function to perform at the same level as younger adults. This project aims to be the first to test this widely-held assumption and will examine changes in cognitive control and the emergence of compensation over the adult ....Cognitive Compensation in Ageing. Decline in cognitive control can have a devastating effect on an individual's capacity to live a high quality and safe independent life. It is an untested assumption that older adults can compensate for age-related changes in cognitive control function to perform at the same level as younger adults. This project aims to be the first to test this widely-held assumption and will examine changes in cognitive control and the emergence of compensation over the adult lifespan (20 to 90 years). The project aims to establish whether cognitive compensation is an effective mechanism to maintain cognitive control function into old age and will inform future strategies to help older individuals live more successful and productive independent lives for longer.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100396
Funder
Australian Research Council
Funding Amount
$342,000.00
Summary
What are the active ingredients of successful shared remembering? Older couples remember more together than apart, but little is known about mechanisms underlying such collaborative benefits. Collaborative remembering may have therapeutic value in age-related cognitive decline and dementia, providing cost-effective, readily-available memory support. However there are several 'active ingredients' that may underlie collaborative benefits and not all of these will be equally effective or translatab ....What are the active ingredients of successful shared remembering? Older couples remember more together than apart, but little is known about mechanisms underlying such collaborative benefits. Collaborative remembering may have therapeutic value in age-related cognitive decline and dementia, providing cost-effective, readily-available memory support. However there are several 'active ingredients' that may underlie collaborative benefits and not all of these will be equally effective or translatable into therapy. This project aims to identify and evaluate these active ingredients, teasing apart 'what', 'who' and 'how'. Testing younger and older couples, healthy and in early stages of decline, this project aims to generate new knowledge and provide a basis for future therapies utilising collaborative remembering.Read moreRead less