Neurocognitive substrates of naming facilitation in aphasia. This research directly addresses the national research priority goal of ageing well, ageing productively, by providing foundational knowledge for improved outcomes in the growing population of individuals in Australia with language impairments from age-related disease. Outcomes of the proposed research will include (1) development of a new theory of word production which can improve treatment of language impairment, (2) an enhanced und ....Neurocognitive substrates of naming facilitation in aphasia. This research directly addresses the national research priority goal of ageing well, ageing productively, by providing foundational knowledge for improved outcomes in the growing population of individuals in Australia with language impairments from age-related disease. Outcomes of the proposed research will include (1) development of a new theory of word production which can improve treatment of language impairment, (2) an enhanced understanding of the cognitive and brain mechanisms involved in word production and its treatment after stroke, and (3) postgraduate training in state-of-the-art cognitive neuroimaging and language neuroscience research. Read moreRead less
How does dopamine modulate adult new word learning? Stroke is a chronic disease of increasing prevalence with increasing age. There is a critical need to develop more effective treatments of communication disorders in this population. One way of achieving this is to combine certain drugs with language therapy. Through studying how these drugs influence language, this research will provide vital knowledge for developing effective forms of pharmacotherapy for adults with language disorders after b ....How does dopamine modulate adult new word learning? Stroke is a chronic disease of increasing prevalence with increasing age. There is a critical need to develop more effective treatments of communication disorders in this population. One way of achieving this is to combine certain drugs with language therapy. Through studying how these drugs influence language, this research will provide vital knowledge for developing effective forms of pharmacotherapy for adults with language disorders after brain injury. More effective language rehabilitation can have direct positive consequences on the ability to regain and maintain employment and social relationships after stroke or brain injury and will address the large and growing social and economic cost to the nation.Read moreRead less
A functional imaging study of semantic processing modulated by dopamine. The role of dopamine in language processing is largely unknown, despite emerging evidence that dopaminergic alterations can modulate language in schizophrenia, Parkinson's disease, and healthy individuals. The research aims to reveal the neural and behavioural correlates of dopaminergic modulation of semantic processing using neuroimaging in healthy individuals who have ingested levodopa. It is hypothesised that levodopa wi ....A functional imaging study of semantic processing modulated by dopamine. The role of dopamine in language processing is largely unknown, despite emerging evidence that dopaminergic alterations can modulate language in schizophrenia, Parkinson's disease, and healthy individuals. The research aims to reveal the neural and behavioural correlates of dopaminergic modulation of semantic processing using neuroimaging in healthy individuals who have ingested levodopa. It is hypothesised that levodopa will modulate brain activity under circumstances where there is heightened semantic competition, consistent with a contemporary theory of dopaminergic cognitive control. The expected outcome of the research is an increased understanding of the interactions between dopamine, the language faculty, and associated neural systems.Read moreRead less
The roles of spectral cues and auditory plasticity in auditory localisation, speech segregation and speech intelligibility. Our recent work shows that high frequency energy in speech is important for the localisation of speech and may also aid in improving speech intelligibility in noisy environments. The work proposed here will systematically explore this somewhat surprising new finding and the results will be incorporated into a predictive model of speech intelligibility under spatial listenin ....The roles of spectral cues and auditory plasticity in auditory localisation, speech segregation and speech intelligibility. Our recent work shows that high frequency energy in speech is important for the localisation of speech and may also aid in improving speech intelligibility in noisy environments. The work proposed here will systematically explore this somewhat surprising new finding and the results will be incorporated into a predictive model of speech intelligibility under spatial listening conditions. This work includes a systematic study of auditory functional plasticity to changes in the spatial cues. Taken together, the outcomes of this work will unlock a range of new approaches to enhancing spatial hearing in multi-channel communication devices and spatial hearing aids.Read moreRead less
New Approaches for Wireless Implantable Biomedical Devices. Wireless biomedical implants of the future will interface with biological systems to perform physiological tasks such as vision restoration, reanimation of paralyzed limbs, and chemical sensing. The potential benefit to society will come not only from alleviating human suffering and improving quality of life, but also by reducing the health care costs now directed to assist people with disabilities such as blindness, stroke and spinal-c ....New Approaches for Wireless Implantable Biomedical Devices. Wireless biomedical implants of the future will interface with biological systems to perform physiological tasks such as vision restoration, reanimation of paralyzed limbs, and chemical sensing. The potential benefit to society will come not only from alleviating human suffering and improving quality of life, but also by reducing the health care costs now directed to assist people with disabilities such as blindness, stroke and spinal-cord injury survivors. Using similar technologies, cochlear implants have already restored functional hearing to over 100,000 deaf patients around the world. The outcomes of the project can also be applied to a variety of other applications such environmental monitoring, security and identification systems. Read moreRead less
Design and Analysis of Optimal Algorithms for Automated Perimetry. Australian demographic studies reveal that visual impairment contributes significantly to disability in the elderly. Glaucoma, the second leading cause of blindness in developed nations, may be slowed if detected early, however recent studies estimate 50% of Australians with glaucoma are undiagnosed. Automated perimetry is used to detect and track such vision loss, but perimetry algorithms perform poorly. This project will design ....Design and Analysis of Optimal Algorithms for Automated Perimetry. Australian demographic studies reveal that visual impairment contributes significantly to disability in the elderly. Glaucoma, the second leading cause of blindness in developed nations, may be slowed if detected early, however recent studies estimate 50% of Australians with glaucoma are undiagnosed. Automated perimetry is used to detect and track such vision loss, but perimetry algorithms perform poorly. This project will design and analyse new algorithms with superior accuracy and efficiency, improving detection and monitoring of vision loss. Enhanced tools for community vision screening will also result, crucial for the ARC's priority goals of ?ageing well, ageing productively? and ?preventative healthcare?Read moreRead less
SPECTRAL TILT: DO INFANTS KNOW WHAT'S GOOD FOR THEM? This project falls within the National Research Priorities, giving children 'a healthy start to life'. The research is important economically because it will lay the groundwork for the informed design of hearing aid frequency responses based on empirical research, and give infants the opportunity to be fitted with hearing aids amplified for infants, not adults as is the current unsatisfactory practice. Moreover, the cross fertilisation of meth ....SPECTRAL TILT: DO INFANTS KNOW WHAT'S GOOD FOR THEM? This project falls within the National Research Priorities, giving children 'a healthy start to life'. The research is important economically because it will lay the groundwork for the informed design of hearing aid frequency responses based on empirical research, and give infants the opportunity to be fitted with hearing aids amplified for infants, not adults as is the current unsatisfactory practice. Moreover, the cross fertilisation of methods and knowledge that the collaborators bring to this grant should provide outcomes that will help maintain attention on Australia as a site of cutting edge research into hearing impairment, hearing aid development and use.Read moreRead less
The ingredients of conscious identification. Research from a variety of psychological domains indicates that a lot of mental processing goes on unconsciously, but that we are only generally aware of a small fraction of the information delivered by our senses. This research will provide new insights into the cognitive and neural mechanisms underlying our conscious and unconscious identification of visual stimuli and will lead to a better understanding of the limitations we are likely to experienc ....The ingredients of conscious identification. Research from a variety of psychological domains indicates that a lot of mental processing goes on unconsciously, but that we are only generally aware of a small fraction of the information delivered by our senses. This research will provide new insights into the cognitive and neural mechanisms underlying our conscious and unconscious identification of visual stimuli and will lead to a better understanding of the limitations we are likely to experience under conditions which make different demands on our perception, attention and the need to remember the relevant information. The results will also inform assessment and remediation of neurological conditions such as stroke and dementia.Read moreRead less
Inhibitory control of retinal sensitivity. We will determine how the nerve cells that carry information from the eye to the brain are always able to provide signals despite very different environments; daylight, fog and night. Knowledge of how nerve cells achieve this rapid learning is important for any understanding of brain function; it is fundamental if we are to develop machines that see or that help restore vision in humans. The project will provide the world's first look at the synaptic ph ....Inhibitory control of retinal sensitivity. We will determine how the nerve cells that carry information from the eye to the brain are always able to provide signals despite very different environments; daylight, fog and night. Knowledge of how nerve cells achieve this rapid learning is important for any understanding of brain function; it is fundamental if we are to develop machines that see or that help restore vision in humans. The project will provide the world's first look at the synaptic physiology that underpins all visual perception, helping to bring Australia back to the forefront of research in this field. This new collaboration between two successful researchers will attract top quality students and researchers from Australia and abroad and be published in major journals.Read moreRead less
Children's Changing Speech Error Patterns: Articulating, Listening, and Thinking. When children are learning to talk, they make many errors of pronunciation. Between speech onset and five years of age, their pronunciations change, gradually approaching adult pronunciations of words. Most children share the same error patterns, although 6% have difficulty acquiring intelligible speech, that affects their academic and social development. The investigation will examine factors that contribute to ....Children's Changing Speech Error Patterns: Articulating, Listening, and Thinking. When children are learning to talk, they make many errors of pronunciation. Between speech onset and five years of age, their pronunciations change, gradually approaching adult pronunciations of words. Most children share the same error patterns, although 6% have difficulty acquiring intelligible speech, that affects their academic and social development. The investigation will examine factors that contribute to the acquisition of speech in normally developing and speech-disordered populations: oro-motor skills, auditory and cognitive processing. Experiments will determine the importance of each domain for speech development. The efficacy of a novel intervention programme for children with speech disorders will be evaluated.Read moreRead less