Novel concepts to engineer low cost blood diagnostics. Novel concepts to engineer low cost blood diagnostics. This project aims to deliver the next generation of on-paper blood diagnostics: cheap, fast, easy to use, reliable, specific and robust. Transformational methods in on-paper and thread-based diagnostics could make indirect and weak blood typing possible. This project expects on-paper testing for fibrinogen to assess clotting capability could revolutionise treatment of massive blood loss. ....Novel concepts to engineer low cost blood diagnostics. Novel concepts to engineer low cost blood diagnostics. This project aims to deliver the next generation of on-paper blood diagnostics: cheap, fast, easy to use, reliable, specific and robust. Transformational methods in on-paper and thread-based diagnostics could make indirect and weak blood typing possible. This project expects on-paper testing for fibrinogen to assess clotting capability could revolutionise treatment of massive blood loss. Expected results of this project are a new class of on-paper and thread-based diagnostic tests with enhanced sensitivity, readability and lower cost, which could significantly affect trauma, rural medicine and developing nations.Read moreRead less
Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer. This project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The project will advance the fundamental science base that underpins dendrimer design and has the potential to deliver substantial benefits in improved drug delivery an ....Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer. This project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The project will advance the fundamental science base that underpins dendrimer design and has the potential to deliver substantial benefits in improved drug delivery and therefore health outcomes for Australia. The interdisciplinary nature of this project will also result in a unique training program for the researchers involved. Such experience is in great demand in Australia where the developing biotechnology and nanotechnology industry is critically short of scientists with skills in drug delivery.Read moreRead less
Controlling the spatial distribution of targeting ligands on dendrimer surfaces as a means of dictating cellular recognition and fate. This project seeks to develop next generation targeted drug delivery systems that 'home' to specific target cells, including cancers. Targeted delivery systems have the potential to revolutionise therapy by providing bespoke drug distribution patterns that are tailored to specific diseases and result in enhanced activity and reduced toxicity.
Industrial Transformation Training Centres - Grant ID: IC170100035
Funder
Australian Research Council
Funding Amount
$4,743,710.00
Summary
ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to devel ....ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to develop ‘smart’ probes and ‘smart’ scanning, harnessing the digital revolution for better, cost effective diagnostic imaging and improved health outcomes.Read moreRead less
Nanoparticle formulations for DNA-targeted radiotherapy and imaging: combinations with chromatin-modifying compounds. This project will develop a new approach for treating and imaging cancer using nanoparticles which target specific cells for cancer therapy and diagnostic imaging. The nanoparticles will be combined with compounds that alter the architecture of DNA to make therapy more effective and to improve the safety of imaging.
Industrial Transformation Research Hubs - Grant ID: IH190100021
Funder
Australian Research Council
Funding Amount
$4,999,540.00
Summary
ARC Research Hub to Combat Antimicrobial Resistance. The ARC ITRP Research Hub to Combat Antimicrobial Resistance takes on the global challenge of antimicrobial resistance (AMR) for Australia through a world-first partnership between industry, researchers, and end users. The AMR Hub fosters a pre-commercialisation environment to address both social and laboratory-based preclinical challenges to provide a highly integrated diagnostic, pharmaceutical and end user solution to the problem of AMR. A ....ARC Research Hub to Combat Antimicrobial Resistance. The ARC ITRP Research Hub to Combat Antimicrobial Resistance takes on the global challenge of antimicrobial resistance (AMR) for Australia through a world-first partnership between industry, researchers, and end users. The AMR Hub fosters a pre-commercialisation environment to address both social and laboratory-based preclinical challenges to provide a highly integrated diagnostic, pharmaceutical and end user solution to the problem of AMR. A goal of the Hub is to support the development of new molecular diagnostic technology, improve the processes for identifying potential antibiotic compounds and assess and advise on antimicrobial stewardship with a vision to transform social and health outcomes globally.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH220100017
Funder
Australian Research Council
Funding Amount
$4,808,669.00
Summary
ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The progra ....ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The program addresses industry-led challenges for translation of biologics as molecular radiopharmaceuticals, building capacity in biomanufacturing, radiobiology and radiochemistry. The program establishes a dedicated manufacturing pipeline, future-proofing production and securing supply chain of next generation medical technologies.Read moreRead less
Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible ....Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible with next-generation lab-on-a-chip technologies and permit rapid throughput diagnostics with potential applications in biomedicine and materials science. Expected project outcomes may also underpin fundamental advances in understanding the interaction of light with nanostructures.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100066
Funder
Australian Research Council
Funding Amount
$443,311.00
Summary
Electrophysiology facility for cell phenotyping and drug discovery. This project aims to establish a high-throughput, automated patch clamp facility to enable research at the forefront of cell phenotyping and drug discovery. Ion channels are membrane proteins that underlie cell function and are therefore important drug targets. The patch clamp technique is the most powerful tool available to functionally characterise cells and study the function of ion channels. The significant advance provided ....Electrophysiology facility for cell phenotyping and drug discovery. This project aims to establish a high-throughput, automated patch clamp facility to enable research at the forefront of cell phenotyping and drug discovery. Ion channels are membrane proteins that underlie cell function and are therefore important drug targets. The patch clamp technique is the most powerful tool available to functionally characterise cells and study the function of ion channels. The significant advance provided by the high-throughput, automated patch clamp system is that it allows up to 384 cells to be recorded simultaneously. This project expects to enhance capacity to automate and standardise the quality of recordings, substantially increase the rate of data production, and enable greater access to patch clamp technology.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less