Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, l ....Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, low-cost, single material technology based on silicon-germanium-carbon thin films for mechanical and optical applications from ultraviolet to long-wave infrared, enabling widespread application of spectroscopic imaging to multiple fields extending from climate change research, through resource exploration, to cancer detection, and aerospace/defense.Read moreRead less
Engineering the Next Generation of Broadband Terahertz Technologies. This project proposes a new broadband, high-power, laser technology for THz sensing. This semiconductor laser based THz technology is crucial for a wide range of applications requiring the acquisition of THz spectral signatures of materials and high-frame rate hyper-spectral THz imaging. We propose two pathways to engineer this novel THz technology: using a tuneable, coupled-cavity quantum cascade semiconductor laser and by c ....Engineering the Next Generation of Broadband Terahertz Technologies. This project proposes a new broadband, high-power, laser technology for THz sensing. This semiconductor laser based THz technology is crucial for a wide range of applications requiring the acquisition of THz spectral signatures of materials and high-frame rate hyper-spectral THz imaging. We propose two pathways to engineer this novel THz technology: using a tuneable, coupled-cavity quantum cascade semiconductor laser and by creating the broad emission spectra through active mode locking in a THz semiconductor laser. The THz laser coupled with the self-detection technique is the key to realising this, and will be explored both in model and experiment.Read moreRead less
Developing orthogonal synthetic signaling cascades. This project proposes a generic approach for the construction of molecular switches based on artificially autoinhibited proteases. The bottom-up design of protein-based signaling networks is a key goal of synthetic biology. Yet, this remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Using structure-guided design and directed protein evolution, a set ....Developing orthogonal synthetic signaling cascades. This project proposes a generic approach for the construction of molecular switches based on artificially autoinhibited proteases. The bottom-up design of protein-based signaling networks is a key goal of synthetic biology. Yet, this remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Using structure-guided design and directed protein evolution, a set of protease-based signal transducers and ligand activated allosteric receptors will be created. The developed components are intended to be used to construct artificial signaling networks in mammalian cells that are orthogonal to the endogenous signaling cascades.Read moreRead less