Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100001
Funder
Australian Research Council
Funding Amount
$345,475.00
Summary
Pushing the limits of fluorescence microscopy with adaptive optics. This project aims to establish an adaptive optics, super-resolution optical microscopy facility to image cellular events with the highest possible spatial resolution, in a whole cell or tissue context. Sophisticated computer-controlled deformable mirrors will be used to correct the way light is distorted as it passes through specimens, thereby overcoming aberrations found in thick and complex samples. This adaptive optics system ....Pushing the limits of fluorescence microscopy with adaptive optics. This project aims to establish an adaptive optics, super-resolution optical microscopy facility to image cellular events with the highest possible spatial resolution, in a whole cell or tissue context. Sophisticated computer-controlled deformable mirrors will be used to correct the way light is distorted as it passes through specimens, thereby overcoming aberrations found in thick and complex samples. This adaptive optics system will enable researchers to study complex behaviour of biological specimens, at the optical resolution limit in plant and animal tissues, leading to basic biology and biotechnology outcomes in biofuels, biomaterials and biomedicines.Read moreRead less
Combating rising sexually transmitted infections among older Australians. This project aims to explore older Australians' knowledge of, and safe sexual practices in regards to, sexually transmitted infections (STIs). STI rates have increased rapidly amongst older age groups in recent years, yet there is a significant research gap concerning older Australians' knowledge of STIs and the preventative sexual practices they engage in. This project is understood to be the only known Australian study c ....Combating rising sexually transmitted infections among older Australians. This project aims to explore older Australians' knowledge of, and safe sexual practices in regards to, sexually transmitted infections (STIs). STI rates have increased rapidly amongst older age groups in recent years, yet there is a significant research gap concerning older Australians' knowledge of STIs and the preventative sexual practices they engage in. This project is understood to be the only known Australian study considering older people's knowledge and practices in relation to STI prevention. In examining this issue the project aims to contribute towards the development of policy and educational resources for older Australians, and is expected to work towards enabling optimal sexual health for older individuals.Read moreRead less
An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling w ....An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling with a novel experimental protocol to allow the study of kinetics of parasite replication in vivo. Expected outcomes will provide significant benefits, such as new avenues for vaccination and immune intervention.Read moreRead less
Highly ordered and tunable extracellular DNA micro- and nanopatterns for investigating the attachment mechanisms of pseudomonas aeruginosa to surfaces. Preventing infectious bacteria from colonising artificial surfaces is a major scientific challenge. New engineered surfaces will be designed to better understand how the important pathogen Pseudomonas aeruginosa sticks to surfaces, facilitating new ways of reducing infections acquired from the surface of, for example, medical devices.
Discovery Early Career Researcher Award - Grant ID: DE130101673
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Access to biomimetic carbohydrate receptors using dynamic combinatorial chemistry. This project aims to utilise novel synthetic technology for the development of cyclic peptide libraries as novel drug leads for the treatment of Dengue virus, HIV and cancer.
Navigating an uncertain antimicrobial future: a sociological study. This project aims to develop a unique understanding of what governs antibiotic use in the health sector and how it can be governed more effectively. The project will critically assess the implementation of governance, and how regulatory and legislative environments may resonate or contrast with the demands of practice. This will support the development of strategies to improve antibiotic use and reduce resistance.
Electromechanical controls of membrane transport phenomena. This joint computational-experimental project will explain transport processes carried out by biological membranes under different physiological and pharmacological conditions, to understand the actions of viruses, toxins, antimicrobial peptides and membrane proteins, for novel therapeutics, drug delivery and bio-sensing applications.
Innovative mathematical modelling to determine incorporation of gene therapy in different cell lineages; Human Immunodeficiency Virus (HIV) as a model setting. Gene therapy is a promising therapeutic that is being developed to address genetic diseases and viral infections such as Human Immunodeficiency Virus (HIV). This project will produce mathematical models of how gene therapy delivered to one type of cell can differentiate into the desired end target and impact disease.