Microbial genomics of the southern ocean: monitoring environmental health. This program will derive an integrated understanding of microbial ecology which is essential for determining ways of preserving the health of the World's ecosystems. Through the development of a unique microbial genomics program, Australia will remain a world leader in Antarctic biology, strengthening Australia's reputation in technologically innovative scientific programs of global significance, training local scientists ....Microbial genomics of the southern ocean: monitoring environmental health. This program will derive an integrated understanding of microbial ecology which is essential for determining ways of preserving the health of the World's ecosystems. Through the development of a unique microbial genomics program, Australia will remain a world leader in Antarctic biology, strengthening Australia's reputation in technologically innovative scientific programs of global significance, training local scientists in cutting edge genomic biology and fostering the interests of the international community in sciences ranging from microbial ecology to climate change.Read moreRead less
Ecological significance of coral disease on the Great Barrier Reef. Coral disease has contributed significantly to the accelerating deterioration of coral reefs globally, but its impact on the Great Barrier Reef is unknown. This project will determine the prevalence of coral disease on the GBR and evaluate the potential threat it poses to reef health. It will build Australian capacity in the ecology and pathology of coral disease, an emergent global research priority, and provide an important ....Ecological significance of coral disease on the Great Barrier Reef. Coral disease has contributed significantly to the accelerating deterioration of coral reefs globally, but its impact on the Great Barrier Reef is unknown. This project will determine the prevalence of coral disease on the GBR and evaluate the potential threat it poses to reef health. It will build Australian capacity in the ecology and pathology of coral disease, an emergent global research priority, and provide an important benchmark for determining whether disease incidence is increasing. It will provide insights into potential links between environmental / anthropogenic stressors and disease incidence, and identify potential threats to coral reef health.Read moreRead less
Antimicrobial defences in the evolution of sociality. Disease microorganisms were probably important selective agents during the evolution of most species. Social insects, the ants, bees, wasps and termites, may have been especially vulnerable because their colonies contain large numbers of closely related individuals living in close proximity; ideal conditions for contagious diseases. We will explore the evolution of antimicrobial defences in social insects and related groups. Social insects ....Antimicrobial defences in the evolution of sociality. Disease microorganisms were probably important selective agents during the evolution of most species. Social insects, the ants, bees, wasps and termites, may have been especially vulnerable because their colonies contain large numbers of closely related individuals living in close proximity; ideal conditions for contagious diseases. We will explore the evolution of antimicrobial defences in social insects and related groups. Social insects are important ecologically and economically and understanding their relationships with microbial diseases will facilitate their conservation and control. Knowledge of these interactions may also prove useful to human societies becoming increasingly vulnerable to disease.Read moreRead less
Microbial community characterisation for bioprocessing of chlorinated hydrocarbon contaminated groundwater. Due to irresponsible industrial practices, Australia has hundreds of polluted soil and water environments. This includes the notorious groundwater contamination underlying Botany in Sydney, an area of rich industrial, residential and cultural significance. The use of microbes to clean up polluted environments, such as the Botany groundwater, is known as bioremediation - a process exploitin ....Microbial community characterisation for bioprocessing of chlorinated hydrocarbon contaminated groundwater. Due to irresponsible industrial practices, Australia has hundreds of polluted soil and water environments. This includes the notorious groundwater contamination underlying Botany in Sydney, an area of rich industrial, residential and cultural significance. The use of microbes to clean up polluted environments, such as the Botany groundwater, is known as bioremediation - a process exploiting the natural metabolic versatility of microbes. To clean up the polluted groundwater in Botany, mixed species communities of pollutant degrading microbes are being produced. Novel tools to reveal the inner workings of these microscopic communities are also being developed, giving Australia an unprecedented advantage in the global bioremediation market.Read moreRead less
Microbial Pathogens as Selective Agents in the Evolution of Arthropod Sociality. We will reveal ecological and evolutionary forces that have shaped a major response of social insects to microbial disease, then apply the results to drug discovery. We will generate the first data on a new approach to antibiotic bioprospecting in the social insects yielding two major outcomes: First, we identify novel sources of antimicrobial compounds. Second, we demonstrate that the new, biorational approach is a ....Microbial Pathogens as Selective Agents in the Evolution of Arthropod Sociality. We will reveal ecological and evolutionary forces that have shaped a major response of social insects to microbial disease, then apply the results to drug discovery. We will generate the first data on a new approach to antibiotic bioprospecting in the social insects yielding two major outcomes: First, we identify novel sources of antimicrobial compounds. Second, we demonstrate that the new, biorational approach is a potent tool for natural product pharmaceutical bioprospecting. Both outcomes contribute directly to the National Research Priority Goal for the Sustainable Use of Australia's Biodiversity by developing new ways to find and identify novel natural resources.
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Environmental metagenomics, metaproteomics and novel bioactives from microbial communities in Antarctic lakes. This program will derive an integrated understanding of microbial ecology which is essential for determining ways of preserving the health of the World's ecosystems. Through this, Australia will remain a world leader in Antarctic biology, strengthening Australia's reputation in technologically innovative scientific programs of global significance, training local scientists in cutting ed ....Environmental metagenomics, metaproteomics and novel bioactives from microbial communities in Antarctic lakes. This program will derive an integrated understanding of microbial ecology which is essential for determining ways of preserving the health of the World's ecosystems. Through this, Australia will remain a world leader in Antarctic biology, strengthening Australia's reputation in technologically innovative scientific programs of global significance, training local scientists in cutting edge genomic biology and fostering the interests of the international community in sciences ranging from microbial ecology to bioprospecting. Novel biodegradable enzymes will be developed to replace harsh chemicals providing environmentally friendly, cheaper and more effective agents for use in medical, biotechnological, industrial and biodefense applications.Read moreRead less
Bacterial disease and bleaching of chemically defended marine algae. Disease has emerged as a major factor in the ecology and management of natural marine communities. Moreover, the impact of disease in marine ecosystems is linked to environmental changes such as global warming. Much of the research in this area has focused on tropical systems (coral reefs). However, in temperate reef systems seaweeds are the major habitat formers. This proposal investigates how environmental factors (temperat ....Bacterial disease and bleaching of chemically defended marine algae. Disease has emerged as a major factor in the ecology and management of natural marine communities. Moreover, the impact of disease in marine ecosystems is linked to environmental changes such as global warming. Much of the research in this area has focused on tropical systems (coral reefs). However, in temperate reef systems seaweeds are the major habitat formers. This proposal investigates how environmental factors (temperature, UV) mediate bacterial disease of seaweeds, key temperate organisms. The proposal thus adresses National Research Priority 1: An Environmentally Sustainable Australia, and in particular the Priority Goals 'Sustainable use of Australia's biodiversity' and 'Responding to climate change and variability'. Read moreRead less
Antimicrobial Defences and Evolution of Sociality. Microbial diseases threaten all societies, human or otherwise. Insect societies present ideal conditions for contagious disease, specifically crowding of closely related individuals. We propose a gradient in the strength and breadth of antimicrobial defences from the solitary to the social condition and this is correlated with increasing crowding and decreasing genetic diversity. To test this hypothesis, we compare the microbial environments o ....Antimicrobial Defences and Evolution of Sociality. Microbial diseases threaten all societies, human or otherwise. Insect societies present ideal conditions for contagious disease, specifically crowding of closely related individuals. We propose a gradient in the strength and breadth of antimicrobial defences from the solitary to the social condition and this is correlated with increasing crowding and decreasing genetic diversity. To test this hypothesis, we compare the microbial environments of nests and colonies, and the antimicrobial mechanisms, of solitary, semi-social and social insects. Outcomes from this research on disease regulation will inform the use, management and conservation of these economically and ecologically important animals.Read moreRead less
Bacterial innovation and evolution: Molecular prospecting by targeting integrons and gene cassettes. Bacteria can respond rapidly to environmental change by acquiring new genes via lateral gene transfer. A DNA element called the integron can capture, mobilise and express genes, thereby playing a role in the transfer process. We have discovered that integrons are surprisingly abundant in the environment and are associated with a hitherto unsuspected diversity of novel genes. In this study we will ....Bacterial innovation and evolution: Molecular prospecting by targeting integrons and gene cassettes. Bacteria can respond rapidly to environmental change by acquiring new genes via lateral gene transfer. A DNA element called the integron can capture, mobilise and express genes, thereby playing a role in the transfer process. We have discovered that integrons are surprisingly abundant in the environment and are associated with a hitherto unsuspected diversity of novel genes. In this study we will assess the diversity of environmental integrons and examine their contribution to bacterial evolution. Further, we aim to use integron systems to prospect for novel genes and contract new enzyme pathways by directed evolution.
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Towards a predictive model for coastal marine microbial assemblages. Coastal regions are overwhelmingly the most intense point of interaction between human activity and oceanic provinces. At this interface, the marine biological ecosystem provides critical services that are required to maintain industrial, economic and social well-being. Our work will identify how these marine systems respond to anthropogenic and climatic variability, National Research Priority 1, and in turn, how this response ....Towards a predictive model for coastal marine microbial assemblages. Coastal regions are overwhelmingly the most intense point of interaction between human activity and oceanic provinces. At this interface, the marine biological ecosystem provides critical services that are required to maintain industrial, economic and social well-being. Our work will identify how these marine systems respond to anthropogenic and climatic variability, National Research Priority 1, and in turn, how this response affects ocean services. This knowledge will inform management efforts in resource and biodiversity conservation, and identify novel areas for future resource exploration.Read moreRead less