Smells that 'taste': Flavour perception and its consequences. The experience of flavour during eating and drinking has surprising social and economic ramifications. Our preference for sweet and fatty food has contributed to progressive increases in body mass over the last twenty years. Many experts now consider this to be a major public health crisis in the making. Economically, Australia is heavily dependent upon food exports, both in terms of primary production and value added processed food ....Smells that 'taste': Flavour perception and its consequences. The experience of flavour during eating and drinking has surprising social and economic ramifications. Our preference for sweet and fatty food has contributed to progressive increases in body mass over the last twenty years. Many experts now consider this to be a major public health crisis in the making. Economically, Australia is heavily dependent upon food exports, both in terms of primary production and value added processed food. Understanding the psychology of flavour, which is central to this project, should assist the development of non-fattening additives that appreciably alter fat and sweetness perception, creating new food products that are healthy, preferred and potential export earners. Read moreRead less
Accuracy and cost-effectiveness of technology-assisted dietary assessment. This project aims to compare leading methods for technology-assisted dietary assessment. Excessive cost and questionable accuracy limit the routine use of dietary assessment and undermine decision making in Australia. This project intends to compare three technology methods of assessing diet with the current standard recall method used in population surveys in order to confirm if the use of food images and automated metho ....Accuracy and cost-effectiveness of technology-assisted dietary assessment. This project aims to compare leading methods for technology-assisted dietary assessment. Excessive cost and questionable accuracy limit the routine use of dietary assessment and undermine decision making in Australia. This project intends to compare three technology methods of assessing diet with the current standard recall method used in population surveys in order to confirm if the use of food images and automated methods provide new approaches to improve accuracy and consumer acceptability. Expected outcomes of this project include more accurate and acceptable methods of assessing dietary intake. These findings will inform decision making for researchers, policy makers and practitioners in Australia, and potentially lead to more regular population surveillance.Read moreRead less
The control of elongation factor 2 and its role in the regulation of protein synthesis. Protein synthesis is a key process in living cells. The main stage, elongation, is regulated through phosphorylation of elongation factor eEF2 in response to hormones, amino acids and cellular energy status, via changes in the activity of eEF2 kinase. We will study how these conditions control eEF2 kinase by studying its phosphorylation and identifying new kinases that regulate it. We will explore the role of ....The control of elongation factor 2 and its role in the regulation of protein synthesis. Protein synthesis is a key process in living cells. The main stage, elongation, is regulated through phosphorylation of elongation factor eEF2 in response to hormones, amino acids and cellular energy status, via changes in the activity of eEF2 kinase. We will study how these conditions control eEF2 kinase by studying its phosphorylation and identifying new kinases that regulate it. We will explore the role of eEF2 in controlling protein synthesis, seek new substrates for eEF2 kinase and initiate work to elucidate the structure of this unusual enzyme. This will enhance, in a range of ways, fundamental understanding of cell physiology.Read moreRead less
Impacts of diet on the brain, body, and microbiome. Dietary habits determine cognitive function, metabolism and the composition of the gut microbiome. This project seeks to clarify the role of the gut microbiome in diet-induced changes to cognition. It aims to do so through longitudinal studies of cognitive function in which dietary patterns are systematically varied, and intervention studies where cognition is tested after experimentally manipulating the gut microbiome. Expected outcomes inclu ....Impacts of diet on the brain, body, and microbiome. Dietary habits determine cognitive function, metabolism and the composition of the gut microbiome. This project seeks to clarify the role of the gut microbiome in diet-induced changes to cognition. It aims to do so through longitudinal studies of cognitive function in which dietary patterns are systematically varied, and intervention studies where cognition is tested after experimentally manipulating the gut microbiome. Expected outcomes include new interdisciplinary knowledge spanning psychology, neuroscience, nutrition and metabolism. This project is timely given the enormous shifts in Australian dietary choices. The knowledge to be gained should provide benefits to individual and public health, agriculture, and food systems.Read moreRead less
Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. T ....Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. This knowledge is highly relevant to any industry or research project utilising living organisms, as nutrient availability supports survival, cell growth and proliferation.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
The Chemistry and Biochemistry of Chromium: Cancer and Nutrition. Of all of the human carcinogens, chromium(VI) has the highest level of occupational exposure, and is of increasing concern as an environmental carcinogen, as highlighted by the film Erin Brockovitch. Similarly, chromium(III) nutritional supplement consumption by humans and animals is rising rapidly, despite mounting concerns about their cancer risks. However, the complexity of Cr biochemistry is such that it is still poorly unde ....The Chemistry and Biochemistry of Chromium: Cancer and Nutrition. Of all of the human carcinogens, chromium(VI) has the highest level of occupational exposure, and is of increasing concern as an environmental carcinogen, as highlighted by the film Erin Brockovitch. Similarly, chromium(III) nutritional supplement consumption by humans and animals is rising rapidly, despite mounting concerns about their cancer risks. However, the complexity of Cr biochemistry is such that it is still poorly understood. This project aims at providing new insights into Cr biochemistry that are of relevance in evaluating risk factors for occupational and environmental exposure and for producing safer Cr dietary supplements.Read moreRead less
Healthy eating campaigns: perceptions of the message and messenger. This project will be a means to evaluate the likely effectiveness of some of the resolutions of the NSW Childhood Obesity Summit aimed at the commercial food industry and the media. The project will provide information for the food industry on consumers' perceptions of their credibility as a source of information about healthy eating. This will inform the development of communication campaigns, as well as provide guidance on de ....Healthy eating campaigns: perceptions of the message and messenger. This project will be a means to evaluate the likely effectiveness of some of the resolutions of the NSW Childhood Obesity Summit aimed at the commercial food industry and the media. The project will provide information for the food industry on consumers' perceptions of their credibility as a source of information about healthy eating. This will inform the development of communication campaigns, as well as provide guidance on development and marketing of 'healthier' brand extensions. The project will also have considerable benefit for public health. The findings will be relevant to government and non-government health promotion organisations considering the effectiveness of social marketing campaigns in association with food companies.Read moreRead less
'Liquid Gold': establishing the place of donated human milk in the tissue economy. Donated human milk can offer profound benefits to the health and survival of hospitalised pre-term infants yet Australia is slow to adopt its use. This research explores the policies and practices of donated human milk use in Australia, and will contribute to the development of donated breast milk policy, and progress current tissue donation theory.
Nutrition insecurity and livelihood decision-making in rural Myanmar. Global progress against malnutrition has been too slow to allow the Millennium Development Goals on hunger to be met. International research has proposed that these failures are due to the fact that the livelihood options available to poor households are increasingly misaligned from their traditional channels for ensuring food and nutrition security. This argument is highly influential in international development research, un ....Nutrition insecurity and livelihood decision-making in rural Myanmar. Global progress against malnutrition has been too slow to allow the Millennium Development Goals on hunger to be met. International research has proposed that these failures are due to the fact that the livelihood options available to poor households are increasingly misaligned from their traditional channels for ensuring food and nutrition security. This argument is highly influential in international development research, underpinning calls for nutrition-sensitive development interventions. The aim of this project is to test the proposition using original survey data collected from 1 600 households in rural Myanmar. This will be the first project of this kind, aiming to shed crucial insight into this issue at this vital moment in Myanmar's transition.Read moreRead less