Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide t ....Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide targets and/or concepts for the pharmacotherapy of obesity.Read moreRead less
Food and trust. The health, well-being and productivity of Australian society is absolutely dependent on a trusted food system. By knowing more about consumer trust in the food system, and in expert advice, we can better tailor ways to improve communication about health and food. We may avoid the problems that have developed in countries where low public trust has damaged the effectiveness of the systems to keep food safe and healthy, and in government and industry efforts to promote better eati ....Food and trust. The health, well-being and productivity of Australian society is absolutely dependent on a trusted food system. By knowing more about consumer trust in the food system, and in expert advice, we can better tailor ways to improve communication about health and food. We may avoid the problems that have developed in countries where low public trust has damaged the effectiveness of the systems to keep food safe and healthy, and in government and industry efforts to promote better eating habits. We will also be able to compare results with those in Europe to gain an international perspective on food trust.Read moreRead less
Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. T ....Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. This knowledge is highly relevant to any industry or research project utilising living organisms, as nutrient availability supports survival, cell growth and proliferation.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Critical windows: understanding changes in eating and physical activity over the transition from secondary school to young adulthood. This project will explain changes in eating, physical activity and sedentary behaviour during the critical period of transition from secondary school to young adulthood. It will provide important information on how we can assist adolescents to maintain a healthy lifestyle over a time characterised by several major life changes.
Omega-3 fats in vegetable oils: Improving their benefits. While authoritative health agencies in Western countries recommend increased intake of omega-3 fats, fish stocks world-wide are already under stress and could not sustain the general uptake of this advice. Nor could aquaculture expansion meet the demand for omega-3 fats with current practices of using wild fish or fish meal or fish oil for feed. This project will address the knowledge gap in how fish handle the omega-3 fatty acids from ve ....Omega-3 fats in vegetable oils: Improving their benefits. While authoritative health agencies in Western countries recommend increased intake of omega-3 fats, fish stocks world-wide are already under stress and could not sustain the general uptake of this advice. Nor could aquaculture expansion meet the demand for omega-3 fats with current practices of using wild fish or fish meal or fish oil for feed. This project will address the knowledge gap in how fish handle the omega-3 fatty acids from vegetable oils such as canola, flaxseed and echium. Australia is well placed in agriculture and aquaculture to capture the value of this research.Read moreRead less
Optimising the Strategy for Breeding Micronutrient-Dense Staple Foods that Improve Human health and Nutrition. The project is part of a new paradigm for agriculture in which staple crops are bred with greater micronutrient density to improve human health. It generates strategic basic information on how nutrients interact in the body of animal models in absorption, transport and utilisation that will allow plant breeders to optimise the breeding strategy for maximum outcomes in health and minimum ....Optimising the Strategy for Breeding Micronutrient-Dense Staple Foods that Improve Human health and Nutrition. The project is part of a new paradigm for agriculture in which staple crops are bred with greater micronutrient density to improve human health. It generates strategic basic information on how nutrients interact in the body of animal models in absorption, transport and utilisation that will allow plant breeders to optimise the breeding strategy for maximum outcomes in health and minimum breeding cost. Animals deficient in the nutrients of most concern (iron, zinc, vitamin A - and inulin) will be fed new varieties with enhanced levels of these factors, and from the responses, a superior strategy will be developed.Read moreRead less