Gene therapy for islet transplantation. Improved understanding of aetiology of type I diabetes. Development of islet transplantation as a clinical therapeutic for type I diabetes. Improved efficacy of islet transplantation. Improved health for subjects with type I diabetes. Decreased diabetic complications. Improved quality of life for subjects with type I diabetes. Reduced burden on health system for management of diabetic complications for subjects with type I diabetes
After the questions: outcomes of routine screening for domestic violence in NSW Health services. Recent research indicates that domestic violence is the leading contributor to death, disability and illness in women aged 15-44 in Australia and leads to health costs of $314 m annually (VicHealth 2004, Access Economics 2004). Routine screening is a low cost measure aimed at prevention and early intervention for domestic violence, which has been successfully introduced for women entering antenatal, ....After the questions: outcomes of routine screening for domestic violence in NSW Health services. Recent research indicates that domestic violence is the leading contributor to death, disability and illness in women aged 15-44 in Australia and leads to health costs of $314 m annually (VicHealth 2004, Access Economics 2004). Routine screening is a low cost measure aimed at prevention and early intervention for domestic violence, which has been successfully introduced for women entering antenatal, early childhood, mental health and drug and alcohol services operated by NSW Health. The research will be the first study of its size to consider the outcomes of routine screening for domestic violence in public health settings in the Australian context.Read moreRead less
Changing the media diet - Investigating the power of the news media to prevent obesity. Australia has 3.7 million obese people - twice as many are overweight. Australian experts say this epidemic, which costs Australia $58 billion a year, requires novel solutions at individual and societal levels. The news media are powerful shapers of public and policymakers' understandings of health issues. This project investigates competing arguments in news media and reality TV and how these frames influenc ....Changing the media diet - Investigating the power of the news media to prevent obesity. Australia has 3.7 million obese people - twice as many are overweight. Australian experts say this epidemic, which costs Australia $58 billion a year, requires novel solutions at individual and societal levels. The news media are powerful shapers of public and policymakers' understandings of health issues. This project investigates competing arguments in news media and reality TV and how these frames influence consumer understandings to discover what role the media are playing in the obesity epidemic. The goal is to relate the findings to scientific evidence and design novel strategic communication interventions to promote health through individual and societal interventions.Read moreRead less
Can and should we link data at a national level? Vaccine safety surveillance: A case study. This project provides many benefits for the community, exploring the legal and ethical issues around consent for data linkage, convening Citizens' Juries to weigh the evidence and make recommendations. It addresses National Research Priorities: Promoting and Maintaining Good Health and Safeguarding Australia as well as National Collaborative Research Infrastructure Strategy priorities. It uses vaccine sa ....Can and should we link data at a national level? Vaccine safety surveillance: A case study. This project provides many benefits for the community, exploring the legal and ethical issues around consent for data linkage, convening Citizens' Juries to weigh the evidence and make recommendations. It addresses National Research Priorities: Promoting and Maintaining Good Health and Safeguarding Australia as well as National Collaborative Research Infrastructure Strategy priorities. It uses vaccine safety surveillance as a case study to evaluate the effectiveness of data linkage (through linking Commonwealth immunisation data to state hospital data) and the methodologies and lessons learnt from cross jurisdictional data linkage can be transferred to other areas. Read moreRead less
New mathematics of fractional diffusion for understanding cognitive impairment at the neuronal level. As Australia's population ages, cognitive impairment due to cortical ageing and neurodegeneration is looming as the nation's greatest health problem. The project will deliver new, more realistic, mathematical models for a mechanistic understanding of cognitive impairment at the neuronal level. This understanding is a vital first step in targeting drugs, e.g., to influence neuronal spine proper ....New mathematics of fractional diffusion for understanding cognitive impairment at the neuronal level. As Australia's population ages, cognitive impairment due to cortical ageing and neurodegeneration is looming as the nation's greatest health problem. The project will deliver new, more realistic, mathematical models for a mechanistic understanding of cognitive impairment at the neuronal level. This understanding is a vital first step in targeting drugs, e.g., to influence neuronal spine properties, for preventative health care. The project will maintain international collaborations, between applied mathematicians at UNSW, Sydney and biomathematicians and neuroscientists at Mount Sinai School of Medicine, New York, providing ongoing training opportunities for Australian scientists in this cutting edge biomathematical research.Read moreRead less
Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits with ....Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits within the school syllabus, is effective, and is scaleable to meet the needs of all schools in Australia. If it reduces the target risk factors by 10-20%, a minimal estimate based on the pilot work, then it will be a most cost effective contribution to promoting and maintaining the good health of the community.
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Paving the way for effective public health interventions for bulimic eating disorders: Understanding stigma and mental health literacy. This research contributes to promoting and maintaining good health. The burden of bulimic eating disorders in the community is high, frequently ignored and increasing. Our research will pave the way for improved understanding of eating disorders and a reduction of stigma in relation to these problems. In so doing, it will lead to reduced shame and suffering for ....Paving the way for effective public health interventions for bulimic eating disorders: Understanding stigma and mental health literacy. This research contributes to promoting and maintaining good health. The burden of bulimic eating disorders in the community is high, frequently ignored and increasing. Our research will pave the way for improved understanding of eating disorders and a reduction of stigma in relation to these problems. In so doing, it will lead to reduced shame and suffering for people with eating disorders and enhance appropriate treatment seeking and the quality of advice received from family, friends and health professionals. A public health intervention based on our findings will contribute to a more tolerant and understanding community.Read moreRead less
Application of Silver Coatings to medical Devices for Antimicrobial Properties using Electroless Deposition. Silver compounds, eg. in topical creams, can be used to treat chronic infections. The results are mediocre, and there may be significant side effects. Metallic silver when coated on bandages or medical devices is gaining wider acceptance, but the dissolution rate muct be improved to minimise infection. In this project an electroless silver coating process will be developed, with bath ch ....Application of Silver Coatings to medical Devices for Antimicrobial Properties using Electroless Deposition. Silver compounds, eg. in topical creams, can be used to treat chronic infections. The results are mediocre, and there may be significant side effects. Metallic silver when coated on bandages or medical devices is gaining wider acceptance, but the dissolution rate muct be improved to minimise infection. In this project an electroless silver coating process will be developed, with bath chemistry and coating conditions optimised for an ideal dissolution rate. This project will lead to the development of improved medical devices that will have significant social and economic benefits for Australia.Read moreRead less
Who acquires infection from whom across international borders? New approaches for control of emerging infections through understanding travel patterns. Mathematical modelling of data on travellers traversing Australia's borders and their contact patterns can be used to understand the pathways by which infectious diseases enter and spread in Australia. Currently available social contact data which informs models are inadequate and outdated. Gathering new data relevant to modern society will help ....Who acquires infection from whom across international borders? New approaches for control of emerging infections through understanding travel patterns. Mathematical modelling of data on travellers traversing Australia's borders and their contact patterns can be used to understand the pathways by which infectious diseases enter and spread in Australia. Currently available social contact data which informs models are inadequate and outdated. Gathering new data relevant to modern society will help control future infectious disease threats to our society. Our aim is to collect detailed, unique data on demography, behavioural and social patterns of travellers and residents, and use this to develop mathematical models to evaluate effective control measures for emerging infections in Australia. This study will make a unique contribution to national disease control policy.Read moreRead less
Pandemic Influenza, Human Resources and Critical Infrastructure Dependencies: Mitigating The Impact on Hospitals. Pandemic planning is conducted from a health-centric model which only considers subsystems within health. This study will determine the impact of a pandemic on the hospital system by failures of human resources and external systems (such as power, finance and teleocmmunications) which comprise critical infrastructure of society. The results will enable identification of key weak poin ....Pandemic Influenza, Human Resources and Critical Infrastructure Dependencies: Mitigating The Impact on Hospitals. Pandemic planning is conducted from a health-centric model which only considers subsystems within health. This study will determine the impact of a pandemic on the hospital system by failures of human resources and external systems (such as power, finance and teleocmmunications) which comprise critical infrastructure of society. The results will enable identification of key weak points, strengthening of health systems and resilience in the event of a pandemic or other disruption.Read moreRead less