Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vesse ....Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vessels influence the function of the kidney. This will lead to predictive models to aid the design and interpretation of physiological studies and the combat of hypertension. It will also help in the ongoing development of bioartificial kidneys to replace present dialysis systems. Read moreRead less
FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of grow ....FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of growing cell and tissue in quantities suitable for implantation or use in other therapeutic applications that are currently deemed impossible.Read moreRead less
Planning and Building Healthy Communities: A multidisciplinary longitudinal study of the relationship between the built environment and human health. This project examines how urban environments support health. Tracking residents’ behaviours over a long time, the study fills a gap in current knowledge about how urban environments manage and promote good health (a national research priority area). It will identify the design features, social interventions and locational qualities in selected sit ....Planning and Building Healthy Communities: A multidisciplinary longitudinal study of the relationship between the built environment and human health. This project examines how urban environments support health. Tracking residents’ behaviours over a long time, the study fills a gap in current knowledge about how urban environments manage and promote good health (a national research priority area). It will identify the design features, social interventions and locational qualities in selected sites which positively benefit human health. The research will describe the likely health outcomes for future Australians living in areas with similar characteristics. It will also strengthen multidisciplinary approaches and policy development in this area by bringing together a team from urban planning, development and health.Read moreRead less
Examining organisational complexity and clinical risk to improve hospital patients' safety. Improving communicative practices will reduce the massive rate and cost of medication errors and hospital-acquired infections. Current costs of hospital-caused incidents are around AU$2 billion per year. These costs are likely to rise further because hospitals are becoming busier, more culturally and linguistically diverse, less generously resourced per patient, and more technologically capable of keeping ....Examining organisational complexity and clinical risk to improve hospital patients' safety. Improving communicative practices will reduce the massive rate and cost of medication errors and hospital-acquired infections. Current costs of hospital-caused incidents are around AU$2 billion per year. These costs are likely to rise further because hospitals are becoming busier, more culturally and linguistically diverse, less generously resourced per patient, and more technologically capable of keeping sicker patients alive for longer, leading to increased clinical risk and more incidents. This project could save around 20% of the total cost of hospital operations by reducing lengths of stay, lowering re-admission rates and ensuring better deployment of clinical resources.Read moreRead less
The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in pa ....The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in particular, children's exposure to ultrafine particles, thus reducing life long impacts, health care cost and productivity losses. The research will also place Australia at the forefront of international progress towards better methods for achieving environmental and public health sustainability.Read moreRead less
Electronic Health Records: Achieving an Effective and Ethical Legal and Recordkeeping Framework. Health records are essential to efficacious treatment and affect every individual. They are 'socially-critical' communications because the therapeutic relationship between doctor and patient is based on trust. Without any systematic ethical and legal safeguards or recordkeeping framework, the application of new technologies for networking health records lacks social credibility. This multidisciplina ....Electronic Health Records: Achieving an Effective and Ethical Legal and Recordkeeping Framework. Health records are essential to efficacious treatment and affect every individual. They are 'socially-critical' communications because the therapeutic relationship between doctor and patient is based on trust. Without any systematic ethical and legal safeguards or recordkeeping framework, the application of new technologies for networking health records lacks social credibility. This multidisciplinary study will provide a set of principles and standards relating to authenticity, ownership, access, privacy, and confidentiality of doctor-patient communications in a networked environment, which, if implemented, will benefit patients and the medical community thus furthering the development of a more efficacious national health system.Read moreRead less
Withholding and withdrawing life-sustaining treatment from adults lacking capacity: Enhancing medical decision-making through doctors' compliance with the law. This project will enhance medical decision-making about the provision of life-sustaining treatment to adults without decision-making capacity through improved compliance with the law. This will advance patients' autonomy and dignity, protect vulnerable adults whose lives may be wrongly ended because of inappropriate treatment decisions a ....Withholding and withdrawing life-sustaining treatment from adults lacking capacity: Enhancing medical decision-making through doctors' compliance with the law. This project will enhance medical decision-making about the provision of life-sustaining treatment to adults without decision-making capacity through improved compliance with the law. This will advance patients' autonomy and dignity, protect vulnerable adults whose lives may be wrongly ended because of inappropriate treatment decisions and avoid litigation for doctors and hospitals. The project also aims to improve the quality of the law by resolving legal ambiguity and proposing reforms. This will further enhance the quality of decision-making, and will reduce defensive medicine and the cost of complying with the law, leading to savings in health expenditure.Read moreRead less
Strengthening the capacity of public health organisations to deliver effective public health services. In an effort to maintain and improve the health of the population Australia has defined the core public health functions that must be carried out. This project will examine public health infrastructure and capacity in three states - mapping the implementation of core functions, assessing current infrastructure, comparing organisational approaches, and developing measures of local public health ....Strengthening the capacity of public health organisations to deliver effective public health services. In an effort to maintain and improve the health of the population Australia has defined the core public health functions that must be carried out. This project will examine public health infrastructure and capacity in three states - mapping the implementation of core functions, assessing current infrastructure, comparing organisational approaches, and developing measures of local public health capacity. These will then become industry benchmarks to guide investment and interventions, and to assess the quality of these. The project will investigate the context in which core public health functions are successfully delivered and develop tools to measure local capacity and delivery functions.Read moreRead less
The Impact of Commercial Funding on Research Team Effectiveness in Health and Medical Research. The Health and Medical Research Sector has seen an increase in collaborations between public and private industry sectors. Consequently, research teams, essentially the functional units that carry out the research, may be funded from commercial and/or non-commercial sources. This project will investigate the impact of commercial funding on research teams. This ground breaking study will be of great va ....The Impact of Commercial Funding on Research Team Effectiveness in Health and Medical Research. The Health and Medical Research Sector has seen an increase in collaborations between public and private industry sectors. Consequently, research teams, essentially the functional units that carry out the research, may be funded from commercial and/or non-commercial sources. This project will investigate the impact of commercial funding on research teams. This ground breaking study will be of great value in the development of research commercialisation policies in Universities, Research Institutes, companies and Government. Its analysis of team effectiveness will assist to identify those characteristics that enhance the performance of research teams, which will have beneficial effects to those who work in them, and ultimately to those who depend on the results of their efforts.Read moreRead less
Developing new methods for building health policy capacity in Australia. This project will contribute to improving the capacity for policy analysis, development and evaluation in the health policy workforce and state health jurisdictions in this country. Building health policy capacity will enable the Australian health system to more effectively address current and emerging challenges including an ageing population, increasing incidence of chronic disease, pressures for cost containment, continu ....Developing new methods for building health policy capacity in Australia. This project will contribute to improving the capacity for policy analysis, development and evaluation in the health policy workforce and state health jurisdictions in this country. Building health policy capacity will enable the Australian health system to more effectively address current and emerging challenges including an ageing population, increasing incidence of chronic disease, pressures for cost containment, continuing poor Aboriginal health and emerging threats to Australia's public health, health security and National Health Strategy.Read moreRead less