ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100010
Funder
Australian Research Council
Funding Amount
$928,291.00
Summary
Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical com ....Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical complexity of traditional tools requiring highly specialised personnel. By offering accessible, easy-to-use advanced systems, this project will significantly boost scientific discovery across physics, chemistry, and biology, fostering collaboration and innovation to better understand life at the molecular level.Read moreRead less
Nanopore sensors for multiplexed, ultra-fast gene detection. The aim of this research is to develop the application of protein nanopores for multiplex identification of DNA samples for ultrafast gene detection. This is a type of barcoding of organism DNA that allows for rapid gene identification. This technology aims to address a significant need for rapid, on-the-spot identification of organisms. Applications include rapid identification of pathogenic bacteria in infections and identification o ....Nanopore sensors for multiplexed, ultra-fast gene detection. The aim of this research is to develop the application of protein nanopores for multiplex identification of DNA samples for ultrafast gene detection. This is a type of barcoding of organism DNA that allows for rapid gene identification. This technology aims to address a significant need for rapid, on-the-spot identification of organisms. Applications include rapid identification of pathogenic bacteria in infections and identification of organisms in environmental sampling. Current methods are relative slow, require DNA amplification and specialised laboratories.
This proposal aims to fine tune the properties of the large nanopore, polyC9, with respect to size and charge, as well as to identify and characterise novel large nanopores. Read moreRead less