Dynamic social systems and adolescent alcohol/tobacco use: A new cusp catastrophe model. This research will substantially improve our understanding of the development of adolescent high-risk behaviours. It will directly inform multimodal prevention strategies by demonstrating how substance use, peer factors, and parent relationships unfold over time. This is much needed because most prevention strategies are too simplistic to address complex precursors to alcohol/tobacco use. The research wil ....Dynamic social systems and adolescent alcohol/tobacco use: A new cusp catastrophe model. This research will substantially improve our understanding of the development of adolescent high-risk behaviours. It will directly inform multimodal prevention strategies by demonstrating how substance use, peer factors, and parent relationships unfold over time. This is much needed because most prevention strategies are too simplistic to address complex precursors to alcohol/tobacco use. The research will benefit health researchers in and beyond Australia who seek to understand behaviours that do not adhere to conventional assumptions. Collaboration with researchers from leading national and international centres will enhance Australia's research reputation and will attract postgraduates and researchers to Australia.Read moreRead less
The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations ....The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations will predict the development of alcohol/tobacco use and misuse, after accounting for viable alternative explanations of the association. Understanding the role that memory associations have in the development of alcohol/tobacco use should inform prevention programs for at-risk adolescents.Read moreRead less
Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits with ....Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits within the school syllabus, is effective, and is scaleable to meet the needs of all schools in Australia. If it reduces the target risk factors by 10-20%, a minimal estimate based on the pilot work, then it will be a most cost effective contribution to promoting and maintaining the good health of the community.
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Addiction, moral identity and moral agency: Integrating theoretical and empirical approaches. By clarifying and evaluating scientific claims about the moral impacts of addiction on the judgment and practices of drug addicted persons and by investigating the perspectives of users and treatment professionals, our project will contribute to the development of ethical and effective public policy, treatment and education programs in the addictions area, thus helping to address the causes and reduce t ....Addiction, moral identity and moral agency: Integrating theoretical and empirical approaches. By clarifying and evaluating scientific claims about the moral impacts of addiction on the judgment and practices of drug addicted persons and by investigating the perspectives of users and treatment professionals, our project will contribute to the development of ethical and effective public policy, treatment and education programs in the addictions area, thus helping to address the causes and reduce the impact of biological, social and environmental factors which diminish life potential in drug addicted persons. The innovative features of this project will enhance Australia's international reputation in bioethics and moral psychology, extend the reach of experimental philosophy, and facilitate future interdisciplinary work.Read moreRead less
Drosophila Quantitative Genomics. This research proposal will be a key element in the emerging program in evolutionary and ecological functional genomics at the University of Queensland. Our studies utilize modern genomics approaches to address diverse national priorities from conservation of biological resources in the face of climate change, to understanding how genetic history contributes to drug susceptibility. The research will contribute to the intellectual foundation upon which rigorous ....Drosophila Quantitative Genomics. This research proposal will be a key element in the emerging program in evolutionary and ecological functional genomics at the University of Queensland. Our studies utilize modern genomics approaches to address diverse national priorities from conservation of biological resources in the face of climate change, to understanding how genetic history contributes to drug susceptibility. The research will contribute to the intellectual foundation upon which rigorous environmental and biomedical research is built. Social impact will be seen in the training of a new generation of integrative genome biologists, and the shaping of attitudes toward the role of genetics in human biology.Read moreRead less
Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Inc ....Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Increasing our knowledge of the causes and consequences of adolescent drug abuse will improve Australia's ability to confront this problem and to develop early interventions and treatments that minimise associated harms.Read moreRead less
Do perceptions of morality of alcohol, tobacco & cannabis use influence uptake in high school? In Australia, the cost of drug use was estimated at $34.4 billion in 1998-89. Preventing or delaying alcohol, tobacco and illicit drug use among adolescents is a way of reducing substance use among adults, and therefore, reduces the health, social and economic costs associated with substance use. This study will assess the protective/vulnerability effect of a range of variables on youth substance use i ....Do perceptions of morality of alcohol, tobacco & cannabis use influence uptake in high school? In Australia, the cost of drug use was estimated at $34.4 billion in 1998-89. Preventing or delaying alcohol, tobacco and illicit drug use among adolescents is a way of reducing substance use among adults, and therefore, reduces the health, social and economic costs associated with substance use. This study will assess the protective/vulnerability effect of a range of variables on youth substance use including morality and legitimacy concepts. These data will guide the development of curriculum components to enhance the effect of school-based interventions with respect to substance use, and provide practical recommendations for community interventions targeted at substance use.Read moreRead less
What works best for youth smoking prevention messages? In Australia, tobacco smoking is the leading cause of preventable death and disease, resulting in over 19,000 deaths annually. The morbidity and mortality associated with smoking costs the community over $21 billion a year. People who start smoking when they are young are more likely to smoke heavily as adults, to become more dependent on nicotine and to be at increased risk of smoking-related illness or death. This research study will provi ....What works best for youth smoking prevention messages? In Australia, tobacco smoking is the leading cause of preventable death and disease, resulting in over 19,000 deaths annually. The morbidity and mortality associated with smoking costs the community over $21 billion a year. People who start smoking when they are young are more likely to smoke heavily as adults, to become more dependent on nicotine and to be at increased risk of smoking-related illness or death. This research study will provide practical recommendations for future tobacco control television advertising targeted at youth in terms of the elements featured in tobacco control advertisements that increase advertising effectiveness. Read moreRead less
The influence of parental alcohol expectancies on offsprings' alcohol expectancies and drinking: A longitudinal study. It has been shown that potentially modifiable alcohol related cognitions, such as alcohol expectancies (AE)and drinking refusal self-efficacy (DRSE) are formed in childhood are related to drinking in adolescents and adults. The question of how these beliefs are formed is still unanswered. This longitudinal study examines the influences of parental alcohol-related beliefs and ....The influence of parental alcohol expectancies on offsprings' alcohol expectancies and drinking: A longitudinal study. It has been shown that potentially modifiable alcohol related cognitions, such as alcohol expectancies (AE)and drinking refusal self-efficacy (DRSE) are formed in childhood are related to drinking in adolescents and adults. The question of how these beliefs are formed is still unanswered. This longitudinal study examines the influences of parental alcohol-related beliefs and drinking, on children's alcohol-related beliefs and drinking behaviour. Positive results of this study will improve primary prevention by identifying and changing modifiable variables for populations potentially at-risk of developing later alcohol-related. It will also help to reduce cost and suffering of a major problem in Ausstralia.
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Determinants of Expression, Assembly and Function of the Noradrenaline Transporter. The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepress ....Determinants of Expression, Assembly and Function of the Noradrenaline Transporter. The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepressant drugs and to the design of drugs to prevent the effects of cocaine.Read moreRead less