Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668374
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies ....State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies and importantly, contribute to Australia's development as a knowledge-based economy.Read moreRead less
Special Research Initiatives - Grant ID: SR0354803
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Interdisciplinary Network for Research into the Ethical, Legal and Social Aspects of Health (ELSAH). Australia lacks a national academic forum to consider issues involving biotechnology, health resource allocation, (bio)ethics and citizenship. This project will
- establish an interdisciplinary network for research into the social, legal and ethical dimensions of healthcare, biotechnology and medical science;
- co-ordinate this expertise in the national interest;
- assist policy makers, resear ....Interdisciplinary Network for Research into the Ethical, Legal and Social Aspects of Health (ELSAH). Australia lacks a national academic forum to consider issues involving biotechnology, health resource allocation, (bio)ethics and citizenship. This project will
- establish an interdisciplinary network for research into the social, legal and ethical dimensions of healthcare, biotechnology and medical science;
- co-ordinate this expertise in the national interest;
- assist policy makers, researchers, technology developers and communities to make informed decisions, and
- make health systems more equitable and socially acceptable.
This in turn will build trust, foster informed debate, increase community input into health policy, and help us understand complex social systems and examine the values embedded in them.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882563
Funder
Australian Research Council
Funding Amount
$120,000.00
Summary
A Multi-Function Eye-Tracker Facility. Eye-tracking data will provide crucial insights into fundamental issues in the areas of (a) decision processes in eyewitness identification, (b) attentional deficits in autism, and (c) the role of saccades in goal-oriented movements. In turn, these advances have important ramifications for (a) the administration of justice, (b) understanding autism and ameliorating its consequences, and (c) the control of movement in normal and disabled populations. The Fa ....A Multi-Function Eye-Tracker Facility. Eye-tracking data will provide crucial insights into fundamental issues in the areas of (a) decision processes in eyewitness identification, (b) attentional deficits in autism, and (c) the role of saccades in goal-oriented movements. In turn, these advances have important ramifications for (a) the administration of justice, (b) understanding autism and ameliorating its consequences, and (c) the control of movement in normal and disabled populations. The Facility brings together a diverse group of established and early career researchers, many of whom have already demonstrated a capacity to collaborate effectively, providing exciting new collaborative research directions that will enhance Australian science and PhD student training.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0345760
Funder
Australian Research Council
Funding Amount
$210,000.00
Summary
Nanoscale Interaction Forces in Particulate and Molecular Systems. We seek to establish a world-class facility for the measurement of nanoscale interaction forces. The ability to measure forces between particles, polymers, emulsion droplets, bubbles, proteins and powders will augment our research capabilities in minerals and material processing, thin film technology, structured surfaces, and in molecular and bio-technology (eg. proteins, DNA, cells, bone, bio-implants). A Molecular Force Probe ....Nanoscale Interaction Forces in Particulate and Molecular Systems. We seek to establish a world-class facility for the measurement of nanoscale interaction forces. The ability to measure forces between particles, polymers, emulsion droplets, bubbles, proteins and powders will augment our research capabilities in minerals and material processing, thin film technology, structured surfaces, and in molecular and bio-technology (eg. proteins, DNA, cells, bone, bio-implants). A Molecular Force Probe (Asylum Research) instrument will allow precise and flexible force measurements on the nano-metre scale. The proposed multi-disciplinary facility will advance research in the areas of engineering, chemistry, pharmacology and biotechnology.
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Asymmetric Synthesis and Biological Evaluation of Bioactive Alkaloids and their Analogues. We propose to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodolo ....Asymmetric Synthesis and Biological Evaluation of Bioactive Alkaloids and their Analogues. We propose to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodology and products developed may have potential pharmaceutical and agricultural applications from which the country could benefit from in the future. This project would help developed skilled people that may develop innovative outcomes in the future, especially in the developing pharmaceutical and biotechnology industries in Australia.Read moreRead less
Regenerating lizard tails: A model for understanding the process of lymphangiogenesis. In humans, impaired lymphatic drainage in limbs causes the debilitating swelling termed lymphoedema. Lymphoedema affects 500,000,000 people worldwide. In the developed world lymphoedema predominantly results from surgery for cancer, and occurs in approximately 25% of breast cancer patients. We will examine lymph vessel regeneration (lymphangiogenesis) in a naturally regenerating, complex structure (the lizard ....Regenerating lizard tails: A model for understanding the process of lymphangiogenesis. In humans, impaired lymphatic drainage in limbs causes the debilitating swelling termed lymphoedema. Lymphoedema affects 500,000,000 people worldwide. In the developed world lymphoedema predominantly results from surgery for cancer, and occurs in approximately 25% of breast cancer patients. We will examine lymph vessel regeneration (lymphangiogenesis) in a naturally regenerating, complex structure (the lizard tail), to describe the regrowth process and determine the abundance, location, functional properties and molecular control of the new lymphatics. Furthermore, if reptilian lymphatic growth factors can promote lymphangiogenesis in mammals, we can design novel therapeutic approaches using reptilian ligands to promote lymphangiogenesis in lymphoedematous human tissues.Read moreRead less
Activation mechanisms of store-operated calcium channels in liver cells. Currently, one of the most active areas of research in biology involves the molecular mechanisms that control the activity of cells. Defining these will provide a deeper understanding of normal function and disease, and provide potential therapeutic targets. This group has an international reputation for its work and it makes a major input to maintaining Australia as a significant contributor to this field. While its resea ....Activation mechanisms of store-operated calcium channels in liver cells. Currently, one of the most active areas of research in biology involves the molecular mechanisms that control the activity of cells. Defining these will provide a deeper understanding of normal function and disease, and provide potential therapeutic targets. This group has an international reputation for its work and it makes a major input to maintaining Australia as a significant contributor to this field. While its research has broad application in biology, its specific focus, calcium signalling in the liver, will provide the basis for understanding liver function and disease and, potentially, for developing new treatments for liver disease associated with abnormal calcium homeostasis.Read moreRead less
Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitri ....Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100149
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Spectroscopic imaging for materials, minerals and life sciences. The spectroscopic imaging equipment highlighted in this proposal will produce a number of outcomes of national benefit. First, it will elevate the impact of research in materials, minerals, and life sciences in Australia, all of which are key areas for the national economy and community. Second, the equipment will be integral to the teaching and research nexus and experiential learning facility for a new wave of materials science ....Spectroscopic imaging for materials, minerals and life sciences. The spectroscopic imaging equipment highlighted in this proposal will produce a number of outcomes of national benefit. First, it will elevate the impact of research in materials, minerals, and life sciences in Australia, all of which are key areas for the national economy and community. Second, the equipment will be integral to the teaching and research nexus and experiential learning facility for a new wave of materials science and engineering students to be educated at UniSA in the EIF-funded M2 building at Mawson Lakes. Finally, the anticipated outcomes of the research to be supported are significant and relate clearly to a number of National Research Priorities.Read moreRead less
Development of novel therapies for the treatment of cancer. Both aging and obesity are significant risk factors for cancer and are becoming a burden on the health care budget. The proposed novel cancer therapy will improve current cancer treatments by enhancing their efficacy, thereby reducing the required dose and minimizing side effects. Such an outcome would not only benefit the well being of the individual but would achieve significant health care cost savings.