Apoptosis And Stem Cells In Cancer Development And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$22,852,198.00
Summary
To improve cancer therapy, we are studying two cancer hallmarks: enhanced cell survival and stem cell-like behaviour. As we discovered, cell death is often blocked in cancer cells. Hence, we are attempting to develop drugs that flip the natural ‘cell death switch’. Stem cells are rare cells that generate entire tissues, as we showed for the breast. Certain cancers may be driven by ‘rogue’ stem cells. If so, eradication of these rare cells within the bulk tumour may require novel therapies.
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
Predicting Renal, Ophthalmic And Heart Events In The Aboriginal Community: The PROPHECY Diabetes Multi-Omics Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$3,955,505.00
Summary
Diabetes is at epidemic levels in Indigenous Australians, impairing quality of life, and contributing to poor health. This is a result of rapid development of kidney, heart and eye complications. We have established a large long-term population study among Aboriginal communities within South Australia and will explore the burden, natural history and the social, psychological, environmental, clinical and genomic predictors of diabetes and its complications.
Alpha-2-Macroglobulin And The Transport And Uptake Of The Hormone, Hepcidin
Funder
National Health and Medical Research Council
Funding Amount
$533,541.00
Summary
Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.
Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100992
Funder
Australian Research Council
Funding Amount
$426,216.00
Summary
A novel epigenetic clock tool to conserve Australia’s threatened seabirds. The aim is to develop a novel epigenetic technique for the demographic assessment of long-lived seabirds, including albatrosses and petrels, for application to the conservation of 11 threatened species breeding across Australia. A major innovation will be an affordable and fieldwork-friendly technique to demographically fingerprint any population, ending the large amount of guesswork currently necessary in management. The ....A novel epigenetic clock tool to conserve Australia’s threatened seabirds. The aim is to develop a novel epigenetic technique for the demographic assessment of long-lived seabirds, including albatrosses and petrels, for application to the conservation of 11 threatened species breeding across Australia. A major innovation will be an affordable and fieldwork-friendly technique to demographically fingerprint any population, ending the large amount of guesswork currently necessary in management. The outcome is expected to enable (i) scientists and wildlife managers to impute the impact of threats and management activities on seabird populations, allowing quantitative scenario modelling, and (ii) stakeholders to analyse numerous threats and optimise management responses to these through research-based decision-making.Read moreRead less
ARC Centre of Excellence for Environmental Decisions. Despite facing the sixth global mass extinction of species, most conservation management is unevaluated and inefficient. The ARC Centre of Excellence for Environmental Decisions will provide international research leadership in tackling the complex problems of environmental management and monitoring in an uncertain world. Working through six Australian universities and six international organisations, the Centre will forge new approaches and ....ARC Centre of Excellence for Environmental Decisions. Despite facing the sixth global mass extinction of species, most conservation management is unevaluated and inefficient. The ARC Centre of Excellence for Environmental Decisions will provide international research leadership in tackling the complex problems of environmental management and monitoring in an uncertain world. Working through six Australian universities and six international organisations, the Centre will forge new approaches and tools from ecology, mathematics, statistics, economics and the social sciences. It will lead the world in developing and delivering predictive models and decision-making approaches to improve outcomes in conservation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100578
Funder
Australian Research Council
Funding Amount
$364,257.00
Summary
The effect of environmental disasters on primate behaviour and distribution. This project aims to study how natural disasters affect animal distribution and behaviour and to predict effects of future disasters. Despite recent increases in environmental disasters, no research has considered their effect on wildlife behaviour and distribution using quantitative methods. This project will create quantitative, multilayered models of climate tolerances and in relation to the effects of natural disast ....The effect of environmental disasters on primate behaviour and distribution. This project aims to study how natural disasters affect animal distribution and behaviour and to predict effects of future disasters. Despite recent increases in environmental disasters, no research has considered their effect on wildlife behaviour and distribution using quantitative methods. This project will create quantitative, multilayered models of climate tolerances and in relation to the effects of natural disasters and behavioural adaptations of affected animals. Anticipated outcomes include improved conservation programmes that reduce the effect of severe weather on wildlife when formulating conservation policy in the face of increasing environmental disasters.Read moreRead less
Biodiversity indicators for better conservation decisions. This project aims to test, design and select biodiversity indicators to support conservation. Reliable and sensitive biodiversity indicators are critical to track progress towards conservation targets, but the ability of most biodiversity indicators to reveal trends needed by decision-makers is untested. This project will test indicators to monitor biodiversity change at local to global scales, by sampling ecosystem models to evaluate ho ....Biodiversity indicators for better conservation decisions. This project aims to test, design and select biodiversity indicators to support conservation. Reliable and sensitive biodiversity indicators are critical to track progress towards conservation targets, but the ability of most biodiversity indicators to reveal trends needed by decision-makers is untested. This project will test indicators to monitor biodiversity change at local to global scales, by sampling ecosystem models to evaluate how indicator design, data bias and environmental variability affect performance. Project outcomes are expected to ensure that that data collected to monitor and assess the state of Australia’s environment are informative, cost-effective and robust. This is expected to have implications for predicting and measuring effects of policy such as the Convention on Biological Diversity.Read moreRead less