Many heart diseases are associated with impairment of energetics of the heart. Improving the heart's energetics can lead to improved survival and long-term outcomes. Perhexiline is a heart medication that works by improving the way the heart uses energy. Although effective, it is associated with long-term toxicities. Better understanding of this medication may lead to less adverse effects and also provide a basis for further investigation of drug development in the future.
The Role Of Cytochrome P-450 Metabolites Of Arachidonic Acid In Human Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$552,610.00
Summary
Alcohol consumption is known to raise blood pressure but the mechanism by which it does this is not known This project examines the role of certain fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450AA-M) during periods of alcohol consumption and periods of abstinance from alcohol. These fatty acid metabolites act on blood vessels causing them to constrict or dilate. In doing this they affect blood pressure regulation. The results of this study will determine ho ....Alcohol consumption is known to raise blood pressure but the mechanism by which it does this is not known This project examines the role of certain fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450AA-M) during periods of alcohol consumption and periods of abstinance from alcohol. These fatty acid metabolites act on blood vessels causing them to constrict or dilate. In doing this they affect blood pressure regulation. The results of this study will determine how important CYP450AA-M are in the development of alcohol related hypertension. We will study CYP450AA-M in cells as well as in plasma and urine to see if cellular levels of CYP450AA-M are better determinants of blood pressure regulation than plasma or urinary levels of CYP450AA-M. This project will help scientists decide how important these metabolites are for blood presssure regulation. If these metabolites are found to be important then it should be possible to alter their levels either by diet or drug treatment.Read moreRead less
The Effect Of Cytochrome P450 Genotype On Blood Pressure And 20-HETE Responses To Lifestyle Interventions
Funder
National Health and Medical Research Council
Funding Amount
$743,665.00
Summary
The effectiveness of treatments to reduce heart disease risk can vary enormously between individuals. This is partly due to a persons genetic makeup. Fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450-AAM) can act on blood vessels and the kidney to regulate blood pressure. We will study the effect of having a variation in a gene that regulates CYP450-AAM on blood pressure and heart disease risk in combination with a high salt diet or weight reduction.