Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new ....Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new insights regarding distrust and intellectual vice, thus significantly advancing knowledge of the ‘dark side’ of social epistemology. Results will lead to urgently required guidance regarding the features of social networks that exacerbate or buffer against the manifestation of these vices.Read moreRead less
Trust in a social and digital world. This project aims to provide a systematic and empirically-informed account of the way networks facilitate or hinder knowledge. Distinguishing on-line information from disinformation can be difficult. This task can be greatly assisted by networks of trusted peers, but figuring out who to trust is itself a challenge. Identifying, designing, and facilitating networks of trust is therefore an urgent task. By using the tools of social epistemology, virtue epistemo ....Trust in a social and digital world. This project aims to provide a systematic and empirically-informed account of the way networks facilitate or hinder knowledge. Distinguishing on-line information from disinformation can be difficult. This task can be greatly assisted by networks of trusted peers, but figuring out who to trust is itself a challenge. Identifying, designing, and facilitating networks of trust is therefore an urgent task. By using the tools of social epistemology, virtue epistemology, and network science, this project will identify how individuals should distribute their trust when embedded in epistemically hostile environments.Read moreRead less
Learned Academies Special Projects - Grant ID: LA170100022
Funder
Australian Research Council
Funding Amount
$118,098.00
Summary
Nourishing Australia: a decadal plan for nutrition science. This project aims to develop a plan to address the complex health and environmental challenges associated with changes in food production and consumption. Since the industrial revolution, our understanding of human diet has lagged behind the rate of change. This project aims to better integrate knowledge across nutrients, foods, meals, diets, and dietary patterns to understand balance rather than single nutrients or commodities. It will ....Nourishing Australia: a decadal plan for nutrition science. This project aims to develop a plan to address the complex health and environmental challenges associated with changes in food production and consumption. Since the industrial revolution, our understanding of human diet has lagged behind the rate of change. This project aims to better integrate knowledge across nutrients, foods, meals, diets, and dietary patterns to understand balance rather than single nutrients or commodities. It will examine the broader context of nutrition from individuals to communities to nations, and globally, and develop a consistent theoretical framework for nutrition that includes both individual biology and the physical, social and biological environment. This will provide broad benefits for social, cultural, economic and health outcomes in the region.Read moreRead less
Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 ....Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 billion pa in lost sales. This project will support the design of new infrastructure and processes to ensure an efficient supply chain. The new science resulting will benefit other coal operations in Australia, and potentially other bulk goods supply chains.Read moreRead less
Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and envi ....Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and environmental economics, and proposes new methodologies to extract preferences that more closely reflect true behaviour in real markets.Read moreRead less
Quantifying the role of the Southern Ocean for anthropogenic CO2 uptake. Carbon dioxide (CO2) is the most important greenhouse gas contributing to global warming and climate change. Climate change is likely to have dramatic economic and environmental consequences for Australia. Knowledge and understanding of the complex carbon cycle is fundamental for predicting future atmospheric CO2 levels and managing climate change. The aim of the work proposed here is to quantify and improve our understan ....Quantifying the role of the Southern Ocean for anthropogenic CO2 uptake. Carbon dioxide (CO2) is the most important greenhouse gas contributing to global warming and climate change. Climate change is likely to have dramatic economic and environmental consequences for Australia. Knowledge and understanding of the complex carbon cycle is fundamental for predicting future atmospheric CO2 levels and managing climate change. The aim of the work proposed here is to quantify and improve our understanding of the oceans role in controlling atmospheric CO2 levels. This will be done by combining modeling and observational expertise among UNSW and CSIRO (Marine Research) researchers. Our work will be the first to assess the extent of which the Southern Ocean (and Australian waters) acts as a carbon sink. This will reduce modeling uncertainties in predicting future atmospheric CO2 levels and will also be valuable to the federal government in future international negotiations on climate change.Read moreRead less
Stable on-demand optimization for workforce and fleet logistics management. This project aims to conceive, develop and deploy innovative methodologies for stable on-demand workforce management and fleet logistics based on advanced decision-support systems. The outcome of this project will provide a new cloud-based real-time Optimisation Software-as-a-Service (OSaaS) platform that allows businesses to improve their productivity while reducing operating costs and their environmental footprint. Thi ....Stable on-demand optimization for workforce and fleet logistics management. This project aims to conceive, develop and deploy innovative methodologies for stable on-demand workforce management and fleet logistics based on advanced decision-support systems. The outcome of this project will provide a new cloud-based real-time Optimisation Software-as-a-Service (OSaaS) platform that allows businesses to improve their productivity while reducing operating costs and their environmental footprint. This is expected to support the manufacturing, retail, delivery and mobile fleets industries.Read moreRead less
Increasing Visitor Frequency: approach to understanding and forecasting how cultural attraction visitors respond to various incentives to increase visitation rates. Museums have been steadily losing visitors over the past decade. While current research indicates that this may be attributed to greater leisure competition, little is understood about how people make choices to visit or not to visit cultural attractions. The aim of this project is to develop, demonstrate and test a Random Utility Th ....Increasing Visitor Frequency: approach to understanding and forecasting how cultural attraction visitors respond to various incentives to increase visitation rates. Museums have been steadily losing visitors over the past decade. While current research indicates that this may be attributed to greater leisure competition, little is understood about how people make choices to visit or not to visit cultural attractions. The aim of this project is to develop, demonstrate and test a Random Utility Theory (RUT)-based modelling approach allowing managers of cultural attractions to understand and predict the likely visitation consequences of potential initiatives. We wish to model visitor choices of museums versus other competing attractions to allow museums to identify specific strategic actions (or combinations) to achieve organisational goals.Read moreRead less
Non-urban water regulation: next generation compliance & enforcement . This project aims to develop the next generation of regulatory technology in non-urban water compliance and enforcement. Effective technologies are needed to make government regulation more efficient, reduce regulatory burdens and improve compliance with complex laws. This project delivers new ways to optimise regulatory technologies that drive innovation, reduce costs and enhance sustainable water use. Expected outcomes incl ....Non-urban water regulation: next generation compliance & enforcement . This project aims to develop the next generation of regulatory technology in non-urban water compliance and enforcement. Effective technologies are needed to make government regulation more efficient, reduce regulatory burdens and improve compliance with complex laws. This project delivers new ways to optimise regulatory technologies that drive innovation, reduce costs and enhance sustainable water use. Expected outcomes include regulatory guidance strategies and training, advances in applied regulatory theory, and innovative technology tools capturing the complexity of water regulation and supporting decision-making. This will provide public resource savings and ensure fairness and effectiveness of water compliance and enforcement.Read moreRead less