The Role Of Seipin In Adipocyte Development And Lipid Droplet Formation
Funder
National Health and Medical Research Council
Funding Amount
$376,258.00
Summary
The prevalence of obesity and its related disorders has reached an alarming level in Australia and other developed countries. Obesity is characterized by the accumulation of fully-differentiated adipocytes loaded with lipid droplets (LDs). We aim to characterize seipin, which regulate both lipid droplet formation and adipocyte differentiation. Results from our proposed studies may offer novel therapeutic strategies against human obesity.
Adrenergic Activation Of Brown Adipose Tissue In Humans.
Funder
National Health and Medical Research Council
Funding Amount
$323,301.00
Summary
Obesity is a major health and financial threat to society in the near future, thus new anti-obesity therapies are essential. Activation of brown adipose tissue (BAT) can increase resting energy expenditure by 20%, and its recent conclusive identification in adults renewed interest in its potential as an anti-obesity target. We will determine whether BAT can be activated pharmacologically in humans, whether obesity reduces its activity and if long-term drug treatment can increase BAT function.