In this grant we will take advantage of procedures uniquely available to the applicant to identify the cell type from which the most prevalent extra cranial solid tumour in children, neuroblastoma (NB), arises during embryonic development. Further studies on this specific cell type will identify the factors controlling their correct embryonic development. Assessment of these molecules as therapeutic targets will then identify novel treatments to inhibit disease progression.
Application Of Omics-based Strategies For Improved Diagnosis And Treatment Of Endocrine Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$461,322.00
Summary
Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. We will define specific omics profiles for patients with a range of hypertension-related disorders by integrating high throughput genetics, genomics and metabolomics data. This should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.