Dietary Intake Of Highly Processed Foods As A Contributor To Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$558,953.00
Summary
Modern food processing imparts desirable functional properties such as emulsification and longer shelf life. These biochemical modifications in our food may cause the body to turn on itself and destroy the cells which produce the sugar storage hormone insulin. This is important for survival and characterizes childhood onset diabetes and can also be seen in type 2 diabetes. This research will test some dietary and pharmaceutical interventions to slow the development of diabetes.
The Role Of Dicarbonyl-derived AGEs And RAGE In Diabetes Associated Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$470,617.00
Summary
Based on our pilot data we postulate that glucose derived molecules such as methylglyoxal (MGO) have effects on inflammation and oxidative stress leading to accelerated atherosclerosis in diabetes. Our studies aim to identify novel treatments which block these effects thus leading to superior protection and prevention of atherosclerosis in diabetes.
Does Excess Consumption Of Dietary Advanced Glycation End Products Activate The Complement Pathway Contributing To Diabetic Nephropathy?
Funder
National Health and Medical Research Council
Funding Amount
$470,617.00
Summary
Modern lifestyle is characterised by the consumption of foods that have been highly processed to improve their shelf life and flavour. However, this food processing has been shown to generate potentially harmful compounds, Advanced Glycation End Products (AGEs) that may promote inflammation and worsen diabetic kidney disease. This study investigates the effects of overeating a diet high in AGEs on the function of the kidney, and aims to find out how these AGEs lead to kidney damage.
A Randomised Controlled Trial Of Aetiology Based Antiemetic Guidelines For Reducing Nausea In Advanced Cancer Patients.
Funder
National Health and Medical Research Council
Funding Amount
$1,152,116.00
Summary
Nausea is a problem that can be very distressing to patients, and one that is difficult to assess and manage in patients with advanced cancer due to its multiple potential causes for this group. This study aims to test the effectiveness of an intervention which uses available anti-nausea medication specifically targeted to the likely cause of nausea for that individual to reduce the severity and impact of the symptom. It also tests second line medicatioins where nausea is unrelieved.