The Healthy Brain Project: A Prospective Cohort Study To Examine How Later-life University Education May Affect The Trajectory Of Ageing-related Cognitive Decline
Funder
National Health and Medical Research Council
Funding Amount
$1,085,742.00
Summary
Previous research has indicated that higher levels of education in early adulthood are associated with lower risk for dementia in older adults. This world-first project will examine if older adults who undertake university education have reduced rates of age-related cognitive decline than older adults who do not undertake further education. This would support the notion that boosting cognitive reserve in later life is protective against age- and disease-related neurodegenerative change.
The role of Eastern Antarctic polynyas in global ocean circulation. This project aims to study Antarctic polynyas, an important, but poorly observed marine habitat, which profoundly influence the global climate. The major water masses of the world's oceans are formed there, making a large contribution to the ocean heat and carbon dioxide uptake. This study will collect data on ocean properties to 2000m from polynyas in eastern Antarctica throughout the Antarctic winter. The outcomes will be the ....The role of Eastern Antarctic polynyas in global ocean circulation. This project aims to study Antarctic polynyas, an important, but poorly observed marine habitat, which profoundly influence the global climate. The major water masses of the world's oceans are formed there, making a large contribution to the ocean heat and carbon dioxide uptake. This study will collect data on ocean properties to 2000m from polynyas in eastern Antarctica throughout the Antarctic winter. The outcomes will be the provision of data of critical importance to oceanographic and climate studies.Read moreRead less
Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data stream ....Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data streams. This project will use high-resolution global and regional ocean/sea-ice models to examine mechanisms for rapid warming of Antarctic continental shelf waters via both large-scale drivers and fine-scale processes, including mesoscale eddies, tide-topography interactions, and bottom boundary flows. This work will better constrain future rates of ice melt around Antarctica by providing vital knowledge of the ocean processes, dynamics, and feedbacks relating to warm water intrusion onto the Antarctic continental shelf.Read moreRead less
Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to ....Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to a broad suite of environmental perturbations (temperature, nutrients, contaminants), will generate stress-response data that can be incorporated alongside eukaryotic data in environmental assessments, greatly improving the ecological relevance and reliability of risk and vulnerability assessments.Read moreRead less
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Modelling Decision Making Within the Household and Analysing its Welfare Implications:Methodological Advances with Policy Applications. The project examines the behavioural and welfare implications of alternative models of intra household decisions. A framework that integrates the household's earnings and expenditure decisions will be proposed and applied. The project introduces new measures of spousal power in making decisions and examines its impact on household outcomes. A satisfactory eco ....Modelling Decision Making Within the Household and Analysing its Welfare Implications:Methodological Advances with Policy Applications. The project examines the behavioural and welfare implications of alternative models of intra household decisions. A framework that integrates the household's earnings and expenditure decisions will be proposed and applied. The project introduces new measures of spousal power in making decisions and examines its impact on household outcomes. A satisfactory econometric methodology to test the conventional unitary model will be developed and applied. The usefulness of this research is underlined by examining the policy implications in areas that range from taxation in the developed country context to child health, child labour and gender bias in case of developing countries.Read moreRead less
The Antarctic Slope Current in a warming climate. Melting Antarctic ice sheets are responsible for 28% of global sea level rise in recent decades, and can contribute more than 1 metre of sea level rise by year 2100, and a staggering 15 metres by 2500. Increased glacial melt rates are best understood by studying changes in the circulation of water around the Antarctic coastline. The combination of physical processes that must be resolved in this region places a high demand on ocean observations a ....The Antarctic Slope Current in a warming climate. Melting Antarctic ice sheets are responsible for 28% of global sea level rise in recent decades, and can contribute more than 1 metre of sea level rise by year 2100, and a staggering 15 metres by 2500. Increased glacial melt rates are best understood by studying changes in the circulation of water around the Antarctic coastline. The combination of physical processes that must be resolved in this region places a high demand on ocean observations and modelling systems. This project uses a series of high-resolution ocean and ice experiments, cross-validated with observations, to provide a deeper understanding of how waters at the Antarctic margin respond to both anthropogenic and natural climate forcing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
The Southern Ocean Meridional Overturning Circulation: New observations of vertical mixing. The Southern Ocean and Antarctic Circumpolar Current (ACC) play profound roles in Australian and global climate. However, we know little about how they will be affected by global warming. New velocity observations will tell us how the vertical mixing that contributes to the meridional overturning circulation, and ACC strength, change with the seasons and from year to year. The observations will also gi ....The Southern Ocean Meridional Overturning Circulation: New observations of vertical mixing. The Southern Ocean and Antarctic Circumpolar Current (ACC) play profound roles in Australian and global climate. However, we know little about how they will be affected by global warming. New velocity observations will tell us how the vertical mixing that contributes to the meridional overturning circulation, and ACC strength, change with the seasons and from year to year. The observations will also give us a better understanding of the oceanic and atmospheric processes that drive these changes. This new information will allow climate models to be better constrained so they can more accurately predict changes to Australian and global climate.Read moreRead less