Our centre combines clinical and laboratory expertise to tackle autoimmune, inflammatory, and immune deficiency diseases. Starting from a genetic discovery platform, we aim to understand precisely how the immune system goes wrong in each individual patient to cause disease. This approach will make diagnoses more accurate and tailor treatment to each patient. The centre's approach should provide a template for the implementation of genomics and personalized medicine into routine clinical practice
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
Role Of SPPL2A On B Cell Survival And Antibody Production In Mice And Humans
Funder
National Health and Medical Research Council
Funding Amount
$592,989.00
Summary
B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.
Researching the Social Role of Religions in Australia. Most Australians claim allegiance to various religions in the Census. The number of religious denominations has greatly increased in recent years, most notably through immigration, with significant numbers from all world religions. Political and social policies are frequently influenced by religious principles and a detailed analysis of this variety is of crucial national importance. Religions from neighbouring societies are significantly r ....Researching the Social Role of Religions in Australia. Most Australians claim allegiance to various religions in the Census. The number of religious denominations has greatly increased in recent years, most notably through immigration, with significant numbers from all world religions. Political and social policies are frequently influenced by religious principles and a detailed analysis of this variety is of crucial national importance. Religions from neighbouring societies are significantly represented in Australia. Understanding them is of central importance in international political and commercial activity. Current research is essential, based on the most recent Census and other recent socio-economic information.
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What makes for successful numeracy education in remote Indigenous contexts: an ethnographic case study approach. There are many successful teachers and schools who have enabled remote Indigenous learners to engage with, and learn, school mathematics. But what do they do? How do they do it? This project investigates and documents successful practices in 32 schools located in remote communities. The project includes the many aspects of teaching practice.
The endangered swift parrot as a model for managing small migratory birds. Endangered swift parrots use variable locations while breeding in eastern Tasmania and over winter on the Australian mainland. This project aims to develop effective conservation strategies for swift parrots and other migrants using new and long term data and innovative technological solutions to tracking small birds across vast landscapes.
Processing mathematics tasks: the nature and role of visual and non-visual reasoning in digital and non-digital environments. Within the next four years, it is likely that the National Assessment Plan for Literacy and Numeracy (NAPLAN) will be administered in a digital mode. This project identifies differences between the delivery of mathematics assessment in pencil-and-paper and computer-based modes. Primary students' mathematics reasoning is compared across these modes and to cohorts from Sing ....Processing mathematics tasks: the nature and role of visual and non-visual reasoning in digital and non-digital environments. Within the next four years, it is likely that the National Assessment Plan for Literacy and Numeracy (NAPLAN) will be administered in a digital mode. This project identifies differences between the delivery of mathematics assessment in pencil-and-paper and computer-based modes. Primary students' mathematics reasoning is compared across these modes and to cohorts from Singapore.Read moreRead less
Processing dynamic graphics: Visuospatial reasoning in mathematics. Increasingly, mathematics competence will be measured in digital and dynamic contexts. Students who possess high visuospatial reasoning are expected to become even better equipped to succeed in science, technology, engineering and mathematics (STEM) related disciplines as technological advances shape how we interpret and decode information. This project explores those aspects of visuospatial reasoning critical for success when s ....Processing dynamic graphics: Visuospatial reasoning in mathematics. Increasingly, mathematics competence will be measured in digital and dynamic contexts. Students who possess high visuospatial reasoning are expected to become even better equipped to succeed in science, technology, engineering and mathematics (STEM) related disciplines as technological advances shape how we interpret and decode information. This project explores those aspects of visuospatial reasoning critical for success when students encounter dynamic mathematics tasks, and attempts to determine whether different forms of visuospatial reasoning are required to decode static and dynamic information. The project aims to better understand how students process mathematics tasks, so the inevitable move toward digital assessment can be managed effectively to promote assessment for learning.Read moreRead less