The cell biology of the albumin-FcRn receptor recycling system. The aim of this project is to define the cell biology of the albumin-FcRn (neonatal Fc receptor) recycling system. FcRn is a recycling membrane receptor that selectively protects serum proteins from intracellular degradation and prolongs their half-life. We will identify the key cell types involved in this recycling pathway, identify intracellular sites of ligand and FcRn interaction, assess the contribution of the haematopoietic sy ....The cell biology of the albumin-FcRn receptor recycling system. The aim of this project is to define the cell biology of the albumin-FcRn (neonatal Fc receptor) recycling system. FcRn is a recycling membrane receptor that selectively protects serum proteins from intracellular degradation and prolongs their half-life. We will identify the key cell types involved in this recycling pathway, identify intracellular sites of ligand and FcRn interaction, assess the contribution of the haematopoietic system and determine ligand half-life in mice. Findings generated will reveal the basic biology of an important physiological receptor, and enable the exploitation of FcRn-receptor interactions for design of recombinant albumin fusion-based therapies.Read moreRead less