Oligomers Of The Alzheimer's Amyloid-? Peptide: Structure, Mechanism Of Toxicity And Small Molecule Interactions
Funder
National Health and Medical Research Council
Funding Amount
$356,324.00
Summary
Alzheimer’s disease is a devastating neurodegenerative disease that currently affects 240 000 Australians. The protein called amyloid-? is found in deposits in the brains of Alzheimer’s patients. The toxic form of this protein is thought to be small aggregated particles called ‘oligomers’. This work aims to investigate the structure of these particles, the reason why they are toxic, as well as their interaction with the neuroprotective compound EGCG, which is found in green tea.