Control Of Combined Simian-human Immunodeficiency Virus Infection Utilising NK Cells Mediating Antigen-specific Antibody Dependent Cellular Cytotoxicity - A Novel Vaccine Modality
Funder
National Health and Medical Research Council
Funding Amount
$432,587.00
Summary
Recently, progress was made in developing a vaccine against HIV. Our laboratory was selected to join a global collaboration trying to elucidate the key to this success. Attention has focused on non-neutralizing antibodies and our laboratory has developed a unique expertise in detecting such immune responses. This research will define, purify and manufacture these antibodies and test their ability to prevent HIV in animals with the ultimate aim of producing a vaccine for human use.
Exploiting the lymphatic system for next generation vaccine development . Vaccination is the most successful and cost-effective means of combating infectious diseases. This project will look at how vaccine adjuvants work and will help the development of new vaccines against infections in both animals and man. It will also promote the training of Australian scientists in the field of vaccine research and development.
New Mechanisms Regulating S100 Protein Function In Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$813,929.00
Summary
This project will examine new ways which affect the major effector cells in allergic inflammation and asthma regulated by novel S100 protein mediators. We find a natural protein (S100A12) of the innate immune system, in cells in the lungs of patients with acute asthma. S100A12 activates mast cells to release mediators that trigger asthma attack. We will characterise the proteins with which this protein binds on the cell surface and and determine how this mediates their activation.