The Role of the Single-Cell Environment in Microbial Invasion. This project aims to use a single-cell approach to develop a quantitative analysis of single-cell interactions to advance our understanding of complex bacterial behaviour fundamental to ecology, industry, technology and disease. Bacteria are ubiquitous on Earth and play key roles in nutrient cycles, biogeochemistry, pathogenesis, symbiosis and bioremediation among other processes. They exhibit complex behaviour and continuously invad ....The Role of the Single-Cell Environment in Microbial Invasion. This project aims to use a single-cell approach to develop a quantitative analysis of single-cell interactions to advance our understanding of complex bacterial behaviour fundamental to ecology, industry, technology and disease. Bacteria are ubiquitous on Earth and play key roles in nutrient cycles, biogeochemistry, pathogenesis, symbiosis and bioremediation among other processes. They exhibit complex behaviour and continuously invade animals, plants and new habitats. These behaviours are poorly understood in natural communities.Read moreRead less
Heavy metal phytotoxicity in long-term contaminated soils: Implications for the development of Australian regulatory guidelines and realistic environmental risk assessment. Heavy metal contamination is a serious global environmental problem. There are >80,000 potentially contaminated sites in Australia alone with many of these sites in the urban environment and former mining areas. The current guidelines for phytotoxicity testing (National Environmental Protection Measure 1999) are based on tota ....Heavy metal phytotoxicity in long-term contaminated soils: Implications for the development of Australian regulatory guidelines and realistic environmental risk assessment. Heavy metal contamination is a serious global environmental problem. There are >80,000 potentially contaminated sites in Australia alone with many of these sites in the urban environment and former mining areas. The current guidelines for phytotoxicity testing (National Environmental Protection Measure 1999) are based on total metal concentrations that do not take into consideration of bioavailability and wide ranging Australian soil types. Serious concerns have been raised on the applicability of these guidelines and their protective limits in ecological risk assessment. This project aims at developing phytotoxicity guidelines applicable to a wide range of soil types common to Australia.Read moreRead less
Surplus baitfish? The consumption and bioenergetics of a predatory fish. This project aims to improve fisheries management of economically important baitfish by increasing our understanding of the ecosystem demand of predatory fish. The ecosystem demand of predatory fish is currently not understood, because it fails to include the considerable impact of juvenile fish, especially when they reside in an estuary. The project intends to implant acoustic transmitters, calibrated in a flume, to discov ....Surplus baitfish? The consumption and bioenergetics of a predatory fish. This project aims to improve fisheries management of economically important baitfish by increasing our understanding of the ecosystem demand of predatory fish. The ecosystem demand of predatory fish is currently not understood, because it fails to include the considerable impact of juvenile fish, especially when they reside in an estuary. The project intends to implant acoustic transmitters, calibrated in a flume, to discover bioenergetic rates in the field by determining the diet and the size- and temperature-dependent growth and biogenetics of a predatory fish species, from juvenile to adult, from estuary to the open sea. The outcomes include an ecosystem synthesis of related pelagic fish predators from catchment to coast.Read moreRead less
Quantitative metrics for determining aquifer ecosystem state. Clean groundwater comes from dirty surface water by way of biological purification. This project will develop quantitative ways to assess groundwater ecosystems to ensure the sustainable extraction of water and maintenance of these crucial ecosystems.
Development Of Diagnostic Tools To Characterise Predictors Of Therapeutic Outcome In Severe Constipation
Funder
National Health and Medical Research Council
Funding Amount
$433,999.00
Summary
This project will use fibre-optic technology to create detailed high resolution maps of colonic motor patterns in both health and in patients with severe constipation. The data will be used in combination with actual patient symptoms to help identify specific markers of disease that can differentiate sub-types of constipation and ultimately guide and improve treatment in constipated patients
Radiostereometric Analysis Of The Effect Of A Large Articulation On Prosthetic Wear And Migration After Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$192,186.00
Summary
At total hip replacement, there has been a recent trend to use prostheses with a larger ball and liner in the socket. This may decrease the risk of post-operative dislocation, but may also increase the amount of wear, leading to bone loss and loosening of prostheses, which may then require replacement. This project will use a special type of x-ray to determine whether wear and movement of these new prostheses is clinically acceptable, so that they can be used with confidence in patients.
The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.
Utilising innovative fishing technology to address key questions on the biology of Antarctic krill. Antarctic krill are an important species in the Southern Ocean supporting most of the Antarctic birds and mammals. A sustainable krill fishery is developing with krill products used in aquaculture and increasingly for human consumption. A new omega 3 krill oil industry has emerged and is rapidly expanding. The aim of the project is to predict the factors governing oil levels and the biochemical co ....Utilising innovative fishing technology to address key questions on the biology of Antarctic krill. Antarctic krill are an important species in the Southern Ocean supporting most of the Antarctic birds and mammals. A sustainable krill fishery is developing with krill products used in aquaculture and increasingly for human consumption. A new omega 3 krill oil industry has emerged and is rapidly expanding. The aim of the project is to predict the factors governing oil levels and the biochemical composition in krill which will help us understand growth, reproduction and recruitment. The research aims to also assess the possible effects of climate change on krill. Outcomes of this research aim to be used to manage the expanding krill fishery.Read moreRead less
Reconstructing past population dynamics to understand human and climatic impacts in prehistory. More than 100 species have become extinct since humans first colonised Australia, and over 1000 are considered threatened. This research will determine the factors most strongly governing the interaction between humans and native fauna in Australia over the last 46 millennia. Our approach is powerful and novel because it will effectively draw together multidisciplinary evidence on natural resource exp ....Reconstructing past population dynamics to understand human and climatic impacts in prehistory. More than 100 species have become extinct since humans first colonised Australia, and over 1000 are considered threatened. This research will determine the factors most strongly governing the interaction between humans and native fauna in Australia over the last 46 millennia. Our approach is powerful and novel because it will effectively draw together multidisciplinary evidence on natural resource exploitation and habitat alteration by ancient people, and the influence of dramatic climatic shifts on the Australian biota. Information on past biological responses to environmental change is critical to properly contextualising the current impact, and long-term consequences of, threats such as global warming, habitat loss and invasive species.Read moreRead less
Declining mental efficiency, cognitive performance and individual differences in aged function. Ageing men's health is poorer than women's and men show lower uptake of public health messages. The project has potential to extend the productive involvement of older men in the community, thereby reducing dependence and health care expenditure. Future benefits could also include an effective, convenient, preliminary screening procedure for tracking abnormal cognitive ageing from an early stage amo ....Declining mental efficiency, cognitive performance and individual differences in aged function. Ageing men's health is poorer than women's and men show lower uptake of public health messages. The project has potential to extend the productive involvement of older men in the community, thereby reducing dependence and health care expenditure. Future benefits could also include an effective, convenient, preliminary screening procedure for tracking abnormal cognitive ageing from an early stage among elderly people. This could be also used to target and evaluate interventions designed to moderate morbidity in ageing, or enhance functional capacity with aging. The project will enhance cross-disciplinary expertise and provide doctoral and postdoctoral research training.Read moreRead less