Developing Innovative Pathways For The Prevention Of Lifelong Cardiovascular Risk
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
My research aims to develop better ways to predict the risk of heart disease, better approaches to disease prevention and treatment and to ultimately develop more effective approaches to implementing these strategies into health care delivery.
Defining Targets And Establishing Methods For Prevention, Diagnosis And Therapy Of Inflammation, Atherosclerosis And Thrombosis
Funder
National Health and Medical Research Council
Funding Amount
$847,490.00
Summary
My research focuses on preventing and treating atherosclerotic disease and its complications such as heart attack and stroke. This will be achieved by developing new imaging technologies, with the aim to detect unstable atherosclerotic plaques, as well as innovative new drugs preventing inflammation and thrombosis as the major contributors of heart attack and stroke.
Oxidative Processes In Vascular Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
The process that turns cut fruit brown when it is exposed to air is thought to cause disease of our blood vessels and heart as we age. Despite what we first thought, 'blocking' this oxidation process with antioxidant supplements does not lower heart disease. This is because oxidation not only causes harm but also is useful and essential for normal body function. Our research program aims to show which oxidative processes are needed for blood vessel health or cause vessel disease.
Identifying Novel Targets To Treat And Prevent Diabetic Complications
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Diabetes is the leading cause for kidney failure requiring dialysis or transplantation. Diabetic patients also have a higher risk to suffer from heart attacks, stroke and amputations in particular once kidney damage occurs. Current strategies fail to completely protect patients from complications. My research will uncover knowledge gaps in our understanding of diabetes complications, identify new targets ultimately leading to urgently needed more effective treatments and prevention strategies to ....Diabetes is the leading cause for kidney failure requiring dialysis or transplantation. Diabetic patients also have a higher risk to suffer from heart attacks, stroke and amputations in particular once kidney damage occurs. Current strategies fail to completely protect patients from complications. My research will uncover knowledge gaps in our understanding of diabetes complications, identify new targets ultimately leading to urgently needed more effective treatments and prevention strategies to reduce the burden of disease in diabetes.Read moreRead less
Understanding The Shared Determinants And Causal Pathways Of Early Life Infection, Inflammation And Atherosclerosis.
Funder
National Health and Medical Research Council
Funding Amount
$632,803.00
Summary
Infection is the commonest reason for childhood hospitalisation, but it is unknown why infection is much more severe in some children. The long-term effects of infection on the development of atherosclerosis (hardening of the arteries), the underlying cause of cardiovascular disease, is also unknown. This research investigates these important questions with the aim of developing better prediction and prevention of severe infection and reducing its impact on adult cardiovascular disease.
The Role Of Oxidative Processes In Atherosclerosis And Related Diseases
Funder
National Health and Medical Research Council
Funding Amount
$966,135.00
Summary
Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings in ....Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings into novel therapeutics and diagnostics.Read moreRead less
A-Prof Wheatley is a respiratory and sleep disorders physician investigating the pathogenesis, health consequences and management of sleep breathing disorders, including sleep apnoea and snoring.
Nox Isoforms And Chemokine Receptors As Therapeutic Targets In Vascular Disease And Stroke
Funder
National Health and Medical Research Council
Funding Amount
$727,758.00
Summary
I am a pharmacologist (a scientist who studies drugs and how they work) trying to find new drugs to treat heart attacks and strokes. I seek to understand the pathways that cause white blood cells and free radicals to accumulate in the walls of arteries in patients with high blood pressure and high cholesterol, and in the brain after stroke. I will then test whether these pathways can be blocked with novel chemical compounds that may eventually be developed into drugs suitable for use in humans.
Prof Trevor Mori has held an NH&MRC Research Fellowship during 2008-2012. This grant will enable him to continue his research program into 2013-2017. Prof Mori is a biomedical research scientist. His research examines the role of diet and lifestyle on risk factors for cardiovascular disease. He also leads the cardiometabolic team examining risk factors in the Western Australian Pregnancy (Raine) Study.