The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler. This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum ....The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler. This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum performance, delivering typically less than 20% of the loaded dose to the target site, the lungs. The new fundamental knowledge resulting from this research will enable the engineering of a high-efficiency groundbreaking DPI, with the potential to be fully adaptive user-specific benefiting millions of Australians. Read moreRead less
Improving respiratory drug delivery through targeted nozzle design. The project aims to develop designs for inhaler components which significantly reduce the existing variability in the sprays they produce, as well as an enhanced capacity to predict inhaler performance through development of new empirical models. This project will combine recently developed synchrotron x-ray measurement techniques with traditional visible light diagnostics to develop a greater understanding of the link between t ....Improving respiratory drug delivery through targeted nozzle design. The project aims to develop designs for inhaler components which significantly reduce the existing variability in the sprays they produce, as well as an enhanced capacity to predict inhaler performance through development of new empirical models. This project will combine recently developed synchrotron x-ray measurement techniques with traditional visible light diagnostics to develop a greater understanding of the link between the geometry of pressurised, metered-dose inhaler components and the drug particles these devices produce. The long term benefit from this research will be improved delivery efficiency and shorter product development times, leading to reduced dose-rate costs. This understanding will enable the development of the next generation of treatment devices with enhanced efficiency in delivery of the drugs used to treat these diseases and reduced costs per dose.Read moreRead less
Engineering an environmentally-friendly metered dose inhaler. This project aims to deliver a novel simulation framework to accurately predict the behaviour of metered dose inhaler sprays using advanced numerical methods for flash-evaporating turbulent flows developed by the investigators. The project expects to generate new knowledge of the complex physics which occur in these devices through a first of its kind combination of unsteady non-equilibrium thermodynamics, turbulence and spray models. ....Engineering an environmentally-friendly metered dose inhaler. This project aims to deliver a novel simulation framework to accurately predict the behaviour of metered dose inhaler sprays using advanced numerical methods for flash-evaporating turbulent flows developed by the investigators. The project expects to generate new knowledge of the complex physics which occur in these devices through a first of its kind combination of unsteady non-equilibrium thermodynamics, turbulence and spray models. Expected outcomes of this project include a novel ability to predict and optimise the performance of inhalers to suit environmentally-friendly replacement propellants. This will significantly benefit the pharmaceutical sector as it will accelerate the design of next-generation inhalers and propellants.Read moreRead less
Enabling precise droplet control in hydrofluorocarbon free sprays. This project aims to investigate the use of blended propellants to replace hydrofluorocarbons in technical aerosols. This project expects to generate new knowledge in the area of multiphase fluid mechanics and aerosol science through a combination of modeling, optical and synchrotron X-ray measurement techniques. Expected outcomes of this project include a capacity to develop environmentally friendly technical aerosol formulation ....Enabling precise droplet control in hydrofluorocarbon free sprays. This project aims to investigate the use of blended propellants to replace hydrofluorocarbons in technical aerosols. This project expects to generate new knowledge in the area of multiphase fluid mechanics and aerosol science through a combination of modeling, optical and synchrotron X-ray measurement techniques. Expected outcomes of this project include a capacity to develop environmentally friendly technical aerosol formulations which can match and potentially outperform currently available hydrofluorocarbon based products. This should provide significant benefits to the pharmaceutical industry through the generation of new knowledge regarding the fundamental physics of multicomponent sprays.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100018
Funder
Australian Research Council
Funding Amount
$362,441.00
Summary
Engineering suspended particle sprays through controlled cavitation. This project aims to use cavitation to engineer particle size in sprays of micronised particles suspended in a propellant, and develop a physical mechanism for this process. Understanding how cavitation affects the size of agglomerates in the liquid phase and droplet size in a spray is critical to developing spray devices that require precise control over the final particle size. This will be achieved through high-resolution op ....Engineering suspended particle sprays through controlled cavitation. This project aims to use cavitation to engineer particle size in sprays of micronised particles suspended in a propellant, and develop a physical mechanism for this process. Understanding how cavitation affects the size of agglomerates in the liquid phase and droplet size in a spray is critical to developing spray devices that require precise control over the final particle size. This will be achieved through high-resolution optical imaging techniques and synchrotron X-ray diagnostics. This project is expected to provide physical insight with applications for inhaled and topical pharmaceutical sprays, and industry spray drying of food products.Read moreRead less
Redefining sediment transport predictions in benthic ecosystems. This project aims to understand and predict the mobilisation of sediment, and the rates and modes of sediment transport. Sediment dynamics control the health and productivity of some of the world’s most valuable marine ecosystems, including seagrass meadows and coral reefs. However, the theory and predictive models needed to quantitatively understand sediment transport over the large bottom roughness in these ecosystems has proven ....Redefining sediment transport predictions in benthic ecosystems. This project aims to understand and predict the mobilisation of sediment, and the rates and modes of sediment transport. Sediment dynamics control the health and productivity of some of the world’s most valuable marine ecosystems, including seagrass meadows and coral reefs. However, the theory and predictive models needed to quantitatively understand sediment transport over the large bottom roughness in these ecosystems has proven elusive. This project will integrate comprehensive laboratory and field programmes to develop predictive models of these sediment dynamics, which should help better understand, manage and protect these critical ecosystems and their services.Read moreRead less
Controlling coastlines while generating power. The Project aims to produce strategies for protecting coasts from storms using farms of wave-energy machines, which also generate electricity. Increasing lengths of coast need protection as the climate changes, but conventional barriers create permanent environmental impacts and are a sunk cost usually borne by the taxpayer. The Project expects to derive a strategy for the setting of each machine in the farm, so that they collectively absorb or refl ....Controlling coastlines while generating power. The Project aims to produce strategies for protecting coasts from storms using farms of wave-energy machines, which also generate electricity. Increasing lengths of coast need protection as the climate changes, but conventional barriers create permanent environmental impacts and are a sunk cost usually borne by the taxpayer. The Project expects to derive a strategy for the setting of each machine in the farm, so that they collectively absorb or reflect damaging waves under severe conditions. Under normal conditions, enough wave energy to sustain environmental processes would pass through. Sales of electricity would help to pay back the capital cost. Outcomes would include reduced coastal-erosion costs and a low-intermittency energy supply.Read moreRead less
Predictive capability for particle capture in aquatic ecosystems. This project investigates the fundamental fluid mechanics of particle capture, whereby suspended particles contact and adhere to a solid structure. This process is examined in productive and biodiverse ecosystems (such as coral reefs and seagrass meadows) whose health, productivity and propagation are directly controlled by particle capture. Existing formulations for particle capture are valid only under highly idealised condition ....Predictive capability for particle capture in aquatic ecosystems. This project investigates the fundamental fluid mechanics of particle capture, whereby suspended particles contact and adhere to a solid structure. This process is examined in productive and biodiverse ecosystems (such as coral reefs and seagrass meadows) whose health, productivity and propagation are directly controlled by particle capture. Existing formulations for particle capture are valid only under highly idealised conditions that are grossly unrepresentative of the complexity of ecosystem flows. The goal of this project is to use a coupled computational-experimental campaign to develop predictive capability for particle capture in ecosystems, where the flow can be turbulent and/or wave-dominated and the biological structures complex.Read moreRead less
The role of turbulence in transporting waterborne material within streambed sediments and across the sediment-water interface. The sediments of rivers, lakes and coastal ocean filter waterborne contaminants. This project uses novel experimental techniques to investigate the role of turbulence in transporting contaminants between water and boundary sediments. This project will inform better management of waterborne contaminants with benefits for human and ecosystem health.
Measuring estuarine turbulence: opening blocked estuaries correctly to avoid ecological catastrophes. The unique estuaries of southern Australia have limited tidal effects and minimal summer river flows, allowing a sandbar to dam their mouths during this period. The high water levels that can result affect landowners so catchment managers artificially break these sandbars. Such practices have had catastrophic effects on the vulnerable estuarine ecosystems. Our project will provide critical eleme ....Measuring estuarine turbulence: opening blocked estuaries correctly to avoid ecological catastrophes. The unique estuaries of southern Australia have limited tidal effects and minimal summer river flows, allowing a sandbar to dam their mouths during this period. The high water levels that can result affect landowners so catchment managers artificially break these sandbars. Such practices have had catastrophic effects on the vulnerable estuarine ecosystems. Our project will provide critical elements of models of the dynamics of the artificial opening, allowing managers to predict the vulnerable periods. It combines new applications of state-of-the-art turbulence sensors and water-current profilers with other standard instrumentation in this situation.Read moreRead less