Imaging The Brain Connectome In Typical And Atypical Development
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
My project will investigate how connections in the brain change during the transition from childhood to adolescence. Advanced neuroimaging techniques will be used to understand how different parts of the brain are connected to one another, and how this changes over time. I will examine typically developing children, as well as those with attention deficit hyperactivity disorder (ADHD) in order to understand how neuropsychiatric disorders affect brain development.
Attention Deficit Hyperactivity Disorder: Genes, Cognition And Brain Activity
Funder
National Health and Medical Research Council
Funding Amount
$428,602.00
Summary
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder of childhood that is marked by age-inappropriate levels of inattention and-or hyperactivity-impulsivity. The disorder appears genetic with a number of different genes likely contributing risk for ADHD. I will use a multi-modal (genetic, cognitive, neurochemical, physiological) approach to increase our understanding of the biological mechanisms leading from gene to disorder in ADHD.
The Genetics Of Cognitive Deficits In Attention Deficit Hyperactivity Disorder (ADHD)
Funder
National Health and Medical Research Council
Funding Amount
$675,512.00
Summary
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder of childhood that is marked by age-inappropriate levels of inattention and-or hyperactivity-impulsivity. The disorder appears genetic with a number of different genes likely contributing risk for ADHD. This project takes an innovative approach by asking whether there are different genetic profiles associated with children with ADHD who do or do not have neurocognitive deficits.
Imaging Genetics Of Attention Deficit Hyperactivity Disorder (ADHD)
Funder
National Health and Medical Research Council
Funding Amount
$321,767.00
Summary
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder of childhood that is marked by age-inappropriate levels of inattention and-or hyperactivity-impulsivity. The disorder appears genetic with a number of different genes likely contributing risk for ADHD. This project takes an innovative approach by asking how risk genes for ADHD influence the brain activity of children with ADHD when they pay attention
Attention deficit hyperactivity disorde(ADHD) is the most prevalent mental disorder of childhood affecting around 7.5% of Australian school age children. The disorder is strongly genetic and causes significant impairments in academic functioning, family and peer relations with sufferers at increased risk for drug abuse. Identification and characterisation of rare mutations will enhance our knowledge of the neurobiology and advance the search for next generation drug treatments for the disorder.
Genetic Influence On Cognitive Function And Medication Response In Attention Deficit Hyperactivity Disorder (ADHD).
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
ADHD is one of the most common child mental health conditions, with cognitive deficits that impact everyday functioning, educational and social outcomes. Not all children with ADHD achieve equal benefit from medication. The disorder appears to be genetic with many genes contributing a small risk for the disorder. This project asks how DNA variation influences ADHD brain function and how they respond to medication. This project is important to improve the clinical diagnosis and outcome for ADHD.
Impact Of A Sleep Intervention In Children With ADHD: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$384,230.00
Summary
Attention deficit hyperactivity disorder (ADHD) affects up to 7.5% of Australian children. Between 50 and 70% of parents also report sleep problems (eg night waking, insomnia) in their child with ADHD. Such sleep problems are associated with poorer child behaviour, concentration, and school attendance as well as poorer parent mental health and work attendance. This randomised controlled trial will determine whether treating sleep problems in children with ADHD can improve these outcomes.
Goal-directed Behaviour In Adolescent ADHD: Neural Connectivity And It’s Significance For Clinical Translation
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Impaired goal-directed decision-making leads to significant difficulties in adolescent attention deficit hyperactivity disorder (ADHD). This research will use novel imaging techniques to study individual-level impairments in brain connectivity in decision making circuits and the effects of common ADHD medications. As these medications are currently prescribed by trial and error, identifying specific connectivity brain signatures will make major contributions to personalised treatment selection.