Signalling And Transcriptional Activity For Craniofacial Morphogenesis In An Experimental Genetic Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$74,755.00
Summary
Abnormalities in craniofacial development affect 2-1000 births in Australia. The aim of this project is to identify genes crucial for the development of the head and face. In particular the project focuses on the Twist1 gene. TWIST1 plays a key role in craniofacial development and individuals lacking functional Twist1display facial anomalies such as craniosynostosis and cleft palate. Dissecting the function of Twist1 is essential to identifying new avenues for the prevention of these defects.
Evaluation Of Circulating Endothelial Cells In Prostate Cancer Detection, Prognosis And Treatment Response
Funder
National Health and Medical Research Council
Funding Amount
$32,628.00
Summary
A current shortfall in clinical medicine is tests which discriminate different forms and severity of cancers. The project will aim to identify useful strategies based on blood factors of angiogenesis, a fundamental process in tumour growth and dissemination. Development of such tests may permit better delineation of prognosis, act as a surrogate marker of treatment efficacy and aid in developing and optimizing new treatments, key areas of need in prostate cancer.
The Role Of Transcriptional Co-activators And Co-repressors During Embryonic Development
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
Every creature starts out as a single fertilized egg. The genome directs the embryonic development of the egg by regulating the expression of genes each of which must be turned on or off at the correct time and place. This essential balance between the activation or repression of genes is controlled by groups of proteins, including ‘transcriptional co-activators’ and ‘repressors’. This project aims to better understand the role of these proteins during embryonic development.