Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less
Evolutionary origins of sexual parasitism in an Australian freshwater fish. Carp gudgeons are the most abundant, widespread and biodiverse freshwater fishes in southeastern Australia. The unacknowledged presence of many cryptic species and sexually-parasitic lineages severely taints all research on this cornerstone group. This project aims to provide unrivalled evolutionary, genomic, and taxonomic insights into this new instance of vertebrate sexual parasitism, which offers a unique mix of resea ....Evolutionary origins of sexual parasitism in an Australian freshwater fish. Carp gudgeons are the most abundant, widespread and biodiverse freshwater fishes in southeastern Australia. The unacknowledged presence of many cryptic species and sexually-parasitic lineages severely taints all research on this cornerstone group. This project aims to provide unrivalled evolutionary, genomic, and taxonomic insights into this new instance of vertebrate sexual parasitism, which offers a unique mix of research advantages not displayed by any other sexual/unisexual complex. The knowledge gained could impact many research fields, including evolutionary theory addressing the unexplainable prevalence of sex, native fish ecology, and environmental monitoring of the Murray-Darling Basin, an ecosystem of world significance.Read moreRead less
Genomics for persistence of Australian freshwater fish. Biodiversity faces an unpredictable cocktail of impacts and global environmental change, against which the best insurance is genetic diversity. We will develop genomic measures of ecological-genetic functions and evolutionary potential for managing Australian freshwater fish.
Unlocking the secrets of the groundwater cycle using Si and Li isotopes. This project aims to determine how non-conventional lithium and silicon isotopes can be used to understand groundwater processes using an innovative source-to-target approach. The project aims to apply these isotope tracers to trace the water cycle within a well constrained system: an island aquifer with a dense borefield which has been analysed using traditional isotopic techniques. Supporting hydrochemical data will be us ....Unlocking the secrets of the groundwater cycle using Si and Li isotopes. This project aims to determine how non-conventional lithium and silicon isotopes can be used to understand groundwater processes using an innovative source-to-target approach. The project aims to apply these isotope tracers to trace the water cycle within a well constrained system: an island aquifer with a dense borefield which has been analysed using traditional isotopic techniques. Supporting hydrochemical data will be used to determine the relationship of the isotopes with environmental processes. The project impact will be the development of new methods to help understand our groundwater resource. The improved process understanding will be translated to groundwater management in general. The projects' focus on carbonate aquifer systems typical of coastal regions of southern, eastern and western Australia will have relevance to groundwater management in urban areas such as Perth and in rural areas for tourism and viticulture, and for management of natural resources in National Parks.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100075
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility wh ....Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility while reducing cost. The expected benefits will advance the elucidation of molecular mechanisms involved in complex biological phenomena. The benefits of this are substantial, including reduction in test compound and reagents, which in turn reduces laboratory costs, conserves cells and increases data quality.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100190
Funder
Australian Research Council
Funding Amount
$620,000.00
Summary
Electrophysiology Platform for Ion-channel Characterisation. Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this p .... Electrophysiology Platform for Ion-channel Characterisation. Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this project aims to develop the first comprehensive toolbox of ion channel modulators using an integrated in vitro/in vivo electrophysiology platform. These pharmacological tools will be made freely available to the Australian research community for probing the mechanism and physiological function of ion channels.Read moreRead less
Water, carbon, and economics: resolving complex linkages for river health. By linking landscapes into our emerging low-carbon economy, this project will investigate how land management practices can be improved through payments for ecosystem services. With a focus on water and carbon, the main goal is to develop mechanisms to support integrated land and water management at the catchment scale.
Mechanisms of sound absorption at the nanoscale. Understanding the interaction of sound with nanoscale structures will guide the creation of novel carbon nanotube materials, optimised for sound absorption, which have potential application anywhere that noise exists and needs to be attenuated. Fuel savings from reduced drag and weight in applications such as jet aircraft engines are also expected.
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
How tired is too tired? Determining the effects of fatigue on pilots' performance in a simulated flight environment. Increasingly, pilots are required to work more flexible flight schedules that expose them to greater levels of work-related fatigue. Consequently, a recent federal parliamentary inquiry recommended that a fatigue risk management approach be applied to the regulation of pilots? flight and duty times. A key aspect of such an approach, and the aim of the proposed project, is to det ....How tired is too tired? Determining the effects of fatigue on pilots' performance in a simulated flight environment. Increasingly, pilots are required to work more flexible flight schedules that expose them to greater levels of work-related fatigue. Consequently, a recent federal parliamentary inquiry recommended that a fatigue risk management approach be applied to the regulation of pilots? flight and duty times. A key aspect of such an approach, and the aim of the proposed project, is to determine the level of fatigue at which pilots? ability to operate an aircraft reaches a safety-critical level. This research will provide a scientifically validated benchmark for regulating pilots? flight and duty times. Ultimately, this will improve safety for the flying public.Read moreRead less