Towards the sustainable discovery and development of new antibiotics. This project aims to define how to access silent biosynthetic genes within microbial genome to facilitate access to new chemical diversity hidden within microbial genomes. Using interdisciplinary approaches in genome mining and metabolomics technologies, the project expects to inspire and enable the future design of more effective antibiotics. Expected outcomes from this program include define new microbial defence molecules, ....Towards the sustainable discovery and development of new antibiotics. This project aims to define how to access silent biosynthetic genes within microbial genome to facilitate access to new chemical diversity hidden within microbial genomes. Using interdisciplinary approaches in genome mining and metabolomics technologies, the project expects to inspire and enable the future design of more effective antibiotics. Expected outcomes from this program include define new microbial defence molecules, to meet future demands in agrochemical and environmental sciences. It will also train future scientists and develop international collaborations. This should provide significant benefit, including a higher-quality workforce for research and innovation, positioning Australia at the forefront of drug discovery. Read moreRead less
Time to shine for constrained peptides as next-generation pharmaceuticals. Current methods for the screening and generation of peptide and protein drugs are laborious, expensive and often incompatible with the biological systems used in pharmaceutical industries. Leveraging recent advancements in chemistry and molecular biology, this project aims to improve the design, synthesis and screening of peptide-based pharmaceuticals. Key research outcomes are innovative biocompatible chemical transforma ....Time to shine for constrained peptides as next-generation pharmaceuticals. Current methods for the screening and generation of peptide and protein drugs are laborious, expensive and often incompatible with the biological systems used in pharmaceutical industries. Leveraging recent advancements in chemistry and molecular biology, this project aims to improve the design, synthesis and screening of peptide-based pharmaceuticals. Key research outcomes are innovative biocompatible chemical transformations for the screening of large peptide libraries, to unleash the revolutionary potential of constrained peptides in drug development. Expected benefits are reliable and cost-effective technologies for the rapid production of biologically active molecules for future targeted use in human and agricultural pharmaceuticals.Read moreRead less
Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the da ....Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the dangerous resonances that can occur during rocket launch, using a combination of experimental, numerical, and theoretical techniques, in partnership with NASA, Stanford, and the CNRS.Read moreRead less
Antimony geochemistry and Earth's dynamic near-surface iron cycle. This project aims to advance our fundamental understanding on the geochemistry of antimony – a critical mineral resource and environmental pollutant of growing concern. This will be achieved by pioneering an innovative combination of advanced synchrotron-based tools and sophisticated isotopic approaches to unravel important interactions between antimony geochemistry and the iron cycle in soils, sediments and aquatic systems. The ....Antimony geochemistry and Earth's dynamic near-surface iron cycle. This project aims to advance our fundamental understanding on the geochemistry of antimony – a critical mineral resource and environmental pollutant of growing concern. This will be achieved by pioneering an innovative combination of advanced synchrotron-based tools and sophisticated isotopic approaches to unravel important interactions between antimony geochemistry and the iron cycle in soils, sediments and aquatic systems. The expected outcomes will provide novel insights into refined strategies to manipulate coupling between antimony mobility and iron cycling for improved rehabilitation of degraded landscapes, safe disposal of hazardous wastes and sustainable exploitation of Australia’s valuable antimony reserves.Read moreRead less
Functional carbon composites to power a sustainable future. This project aims to address the limitation of current energy storage technologies though the development of functional carbon-based materials for the next generation of energy storage systems with high capacity, high energy/power density, excellent retention and low cost. The progress of energy storage technology plays a critical role in the development of portable devices in daily life. This project will synthesise a series of carbon- ....Functional carbon composites to power a sustainable future. This project aims to address the limitation of current energy storage technologies though the development of functional carbon-based materials for the next generation of energy storage systems with high capacity, high energy/power density, excellent retention and low cost. The progress of energy storage technology plays a critical role in the development of portable devices in daily life. This project will synthesise a series of carbon-based composites via an electrospinning method, and their properties will be assessed and characterised as electrode materials for high performance energy storage devices.Read moreRead less
Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed ....Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed by new scientific knowledge and data. The proliferation of these new models will allow the design and operation of more efficient, reliable and quieter technologies in the aerospace, naval and energy industries, benefitting the Australian economy and environment, and raise the international profile of our scientists.Read moreRead less
Biomimetic surface coatings for drag and fouling reduction. This project aims to provide new insights into liquid flow and adsorption at liquid/solid and liquid/liquid interfaces, by using a combination of theoretical predictions, nanoscale techniques and nanofabrication approaches. Expected outcomes are the development of liquid-repellent slippery surface coatings that reduce hydrodynamic drag and inhibit marine fouling. This will benefit the fields of advanced manufacturing and smart coatings, ....Biomimetic surface coatings for drag and fouling reduction. This project aims to provide new insights into liquid flow and adsorption at liquid/solid and liquid/liquid interfaces, by using a combination of theoretical predictions, nanoscale techniques and nanofabrication approaches. Expected outcomes are the development of liquid-repellent slippery surface coatings that reduce hydrodynamic drag and inhibit marine fouling. This will benefit the fields of advanced manufacturing and smart coatings, and will underpin a wide range of energy efficient processes and products. Slippery coatings will solve urgent environmental problems of social value by improving the energy and chemical efficiency in fluid flow, heat transfer, secondary oil recovery, microfluidics, and anti-fouling.Read moreRead less
Robust and Explainable 3D Computer Vision. Computer vision is increasingly relying on deep learning which is fragile, opaque and fails catastrophically without warning. This project aims to address these problems by developing new theory in graph representation of 3D geometric and image data, hierarchical graph simplification and novel modules designed specifically for deep learning over geometric graphs. Using these modules, it aims to design graph convolutional network architectures for self-s ....Robust and Explainable 3D Computer Vision. Computer vision is increasingly relying on deep learning which is fragile, opaque and fails catastrophically without warning. This project aims to address these problems by developing new theory in graph representation of 3D geometric and image data, hierarchical graph simplification and novel modules designed specifically for deep learning over geometric graphs. Using these modules, it aims to design graph convolutional network architectures for self-supervised learning that are robust to failures and provide explainable decisions for object detection and scene segmentation. The outcomes are expected to advance theory in robust deep learning and benefit 3D mapping, surveying, infrastructure monitoring, transport and robotics industries.Read moreRead less
Energy Source Durability for Electric Vertical TakeOff and Landing Aircraft. This project aims to address energy source durability for electric Vertical Take Off and Landing (eVTOL) aircraft by optimising a fuel cell/battery/ultracapacitor triple hybrid energy system. The project expects to generate new knowledge in the area of energy source durability using interdisciplinary approaches that combine energy source degradation models, hardware-in-the-loop simulations, aero-propulsive flight mechan ....Energy Source Durability for Electric Vertical TakeOff and Landing Aircraft. This project aims to address energy source durability for electric Vertical Take Off and Landing (eVTOL) aircraft by optimising a fuel cell/battery/ultracapacitor triple hybrid energy system. The project expects to generate new knowledge in the area of energy source durability using interdisciplinary approaches that combine energy source degradation models, hardware-in-the-loop simulations, aero-propulsive flight mechanics models, and accelerated degradation testing. This should provide significant benefits, allowing to fast-track the improved longevity needed for cost-competitive long-range rapid response air ambulance eVTOL operations.Read moreRead less
Advancing cycling as an active transport mode using data driven approaches. This research program aims to provide the critical evidence that is needed to advance cycling as an active and sustainable mode of transport. Through interdisciplinary research and multi-national collaborations, the program will develop a world-leading data platform that will monitor, inform and evaluate cycling, and use this platform to provide the evidence that is needed to enhance cycling participation, safety and inf ....Advancing cycling as an active transport mode using data driven approaches. This research program aims to provide the critical evidence that is needed to advance cycling as an active and sustainable mode of transport. Through interdisciplinary research and multi-national collaborations, the program will develop a world-leading data platform that will monitor, inform and evaluate cycling, and use this platform to provide the evidence that is needed to enhance cycling participation, safety and infrastructure. The outcomes of the research will revolutionise our ability to implement safe and connected cycling infrastructure in areas of greatest need, leading to reduced injury, greater equity and wider uptake of cycling as a mode of transport, thereby leading to substantial gains in population and environmental health.Read moreRead less