The impact of endocrine disrupting compounds (EDCs) in sewage contaminated waters on aquatic biota and identification of the causative compounds. The project's aims are to determine a) the impact of endocrine disrupting compounds (EDCs) such as contraceptive pills and detergents in sewage effluent on aquatic biota; and b) which EDCs contribute to the impact. This project will provide the first comprehensive assessment of whether EDCs are causing effects in rivers downstream of sewage treatment p ....The impact of endocrine disrupting compounds (EDCs) in sewage contaminated waters on aquatic biota and identification of the causative compounds. The project's aims are to determine a) the impact of endocrine disrupting compounds (EDCs) such as contraceptive pills and detergents in sewage effluent on aquatic biota; and b) which EDCs contribute to the impact. This project will provide the first comprehensive assessment of whether EDCs are causing effects in rivers downstream of sewage treatment plants and will identify the chemicals responsible. New biological tests for detecting endocrine disruption will also be developed for research and commercial use. The findings will assist regulatory bodies and water service providers to develop appropriate legislative, management and technological strategies to minimise EDC impacts on ecosystem health.Read moreRead less
New Stochastic Processes with Applications in Finance. This project investigates the properties and the use of two new families of models with applications in Finance, and beyond. It will contribute to the development of fundamental research in mathematics and its applications. The project will produce more realistic financial models that will benefit researchers in this field. This will in turn have a flow on effect to benefit the wider community. The project will provide for postgraduate train ....New Stochastic Processes with Applications in Finance. This project investigates the properties and the use of two new families of models with applications in Finance, and beyond. It will contribute to the development of fundamental research in mathematics and its applications. The project will produce more realistic financial models that will benefit researchers in this field. This will in turn have a flow on effect to benefit the wider community. The project will provide for postgraduate training and international scientific exchange. Overall, the project will strengthen Australia's standing at the forefront of fundamental and applied research.Read moreRead less
The pricing and risk management of reverse mortgages in the Australian market. This project will develop new methodologies for the pricing of reverse mortgages and will examine how sensitive prices are to demographic and financial assumptions in our models. This will increase transparency in the reverse mortgage market for retired Australians and ensure they get a fair deal. Increasing pricing transparency will also reduce risks to the issuing banks both by facilitating securitization and by all ....The pricing and risk management of reverse mortgages in the Australian market. This project will develop new methodologies for the pricing of reverse mortgages and will examine how sensitive prices are to demographic and financial assumptions in our models. This will increase transparency in the reverse mortgage market for retired Australians and ensure they get a fair deal. Increasing pricing transparency will also reduce risks to the issuing banks both by facilitating securitization and by allowing more accurate modelling of capital costs for mortgages that remain on their balance sheet.Read moreRead less
Human skin equivalent constructs: enhanced culturing and application of laboratory-grown skin through mathematical modelling and in silico experimentation. Laboratory-grown human skin equivalent constructs, given social and legislative imperatives, will be critical for advances in novel treatment protocol definitions for wound repair, dermatogical screening of pharmacueticals and fundamental studies of skin diseases.
In silico studies undertaken in this project will make a significant contrib ....Human skin equivalent constructs: enhanced culturing and application of laboratory-grown skin through mathematical modelling and in silico experimentation. Laboratory-grown human skin equivalent constructs, given social and legislative imperatives, will be critical for advances in novel treatment protocol definitions for wound repair, dermatogical screening of pharmacueticals and fundamental studies of skin diseases.
In silico studies undertaken in this project will make a significant contribution to the effectiveness of the application of human skin constructs, by delivering new and deeper insights into the interplay between dependent processes that regulate the behaviour of skin, in vivo or ex vivo. The models and the researchers associated with this project will drive innovative studies in medical science over the next decade.Read moreRead less
A Mathematical Model of the Roles of Contraction and Oxygen in Human Wound Healing. Slow or impaired wound healing and excessive scarring associated with burns are both painful and costly. Moreover, the debilitating effect of chronic wounds can be expected to increase with the continuing aging of the population and the current rise in incidence of Type 2 diabetes. This project brings together a multidisciplinary team to develop a mathematical model of human wound healing and to drive the modelli ....A Mathematical Model of the Roles of Contraction and Oxygen in Human Wound Healing. Slow or impaired wound healing and excessive scarring associated with burns are both painful and costly. Moreover, the debilitating effect of chronic wounds can be expected to increase with the continuing aging of the population and the current rise in incidence of Type 2 diabetes. This project brings together a multidisciplinary team to develop a mathematical model of human wound healing and to drive the modelling to generate important breakthroughs at the level of basic science with implications for both experimentalists and clinicians.Read moreRead less
A new hierarchy of mathematical models to quantify the role of ghrelin during cell invasion. Ghrelin is a recently-discovered growth factor that regulates appetite and promotes tumour growth by enhancing cell invasion. The mechanisms by which ghrelin enhances cell invasion are, at present, unknown. This innovative project will develop a new hierarchy of multiscale mathematical models that will be used to quantify how ghrelin modulates cell behaviour (motility, proliferation and death) and provid ....A new hierarchy of mathematical models to quantify the role of ghrelin during cell invasion. Ghrelin is a recently-discovered growth factor that regulates appetite and promotes tumour growth by enhancing cell invasion. The mechanisms by which ghrelin enhances cell invasion are, at present, unknown. This innovative project will develop a new hierarchy of multiscale mathematical models that will be used to quantify how ghrelin modulates cell behaviour (motility, proliferation and death) and provide insight into the precise details of how ghrelin promotes cell invasion. This project will demonstrate the potential for ghrelin-based strategies to control cell invasion. By linking appetite regulation and tumour growth, the outcomes from this project will inform Australian health policy in this important area.Read moreRead less
Fundamental mathematical structures in statistical and quantum systems. Mathematics is playing a key role in modern science and technology. This project will bring together world leading experts from Australia and the USA to unravel the most fundamental mathematical structures in of statistical and quantum systems arising in settings ranging from physics of tiny quantum dots to string theory in high energy physics. This research will ensure Australia's involvement in cutting-edge international d ....Fundamental mathematical structures in statistical and quantum systems. Mathematics is playing a key role in modern science and technology. This project will bring together world leading experts from Australia and the USA to unravel the most fundamental mathematical structures in of statistical and quantum systems arising in settings ranging from physics of tiny quantum dots to string theory in high energy physics. This research will ensure Australia's involvement in cutting-edge international developments in mathematical sciences poised to deliver new significant results in the fundamental quantum theory of matter. The project will also contribute to training young researchers to maintain Australia's international standing in fundamental science.Read moreRead less
Creating subject-specific mathematical models to understand the brain. This project aims to develop a mathematical framework that bridges the different scales of brain activities to provide a new tool for understanding the brain. Methods will be developed that unify individual neural activity with large scale brain activity. The approach will be validated by comparing predictions of interconnected models of neural populations (called mean-field models) to experimental data. The creation of subje ....Creating subject-specific mathematical models to understand the brain. This project aims to develop a mathematical framework that bridges the different scales of brain activities to provide a new tool for understanding the brain. Methods will be developed that unify individual neural activity with large scale brain activity. The approach will be validated by comparing predictions of interconnected models of neural populations (called mean-field models) to experimental data. The creation of subject-specific models from data is important, as there is large variability in neural circuits between individuals despite seemingly similar network activity. The intended outcome is new insights into the processes that govern brain function and methods for improving functional imaging of, and interfacing to, the brain.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100110
Funder
Australian Research Council
Funding Amount
$3,021,288.00
Summary
New Approaches to Understand How Form and Function Shape Complex Systems. As biology and medicine transform into quantitative sciences, existing mathematical methods are often inadequate to explain the data they generate. This project aims to unlock the potential of such biomedical data through the development of new mathematical approaches that combine concepts from pure and applied mathematics, statistics and data science, and then to investigate their ability to generate mechanistic insight i ....New Approaches to Understand How Form and Function Shape Complex Systems. As biology and medicine transform into quantitative sciences, existing mathematical methods are often inadequate to explain the data they generate. This project aims to unlock the potential of such biomedical data through the development of new mathematical approaches that combine concepts from pure and applied mathematics, statistics and data science, and then to investigate their ability to generate mechanistic insight into fundamental biomedical processes. In this way, the project expects to affect a paradigm shift in mathematical biology while strengthening Australia’s reputation as a world-leader in mathematical biology. An outcome from this project could be new mathematical models that guide decision making in the clinic.Read moreRead less