Investigation Of The Roles Of Foxn1, Wnts And Autophagy In The Development And Function Of Thymic Epithelial Cells.
Funder
National Health and Medical Research Council
Funding Amount
$220,222.00
Summary
The immune system usually protects the body from infections. Occasionally, the immune system mistakenly recognises components of the body as foreign and attacks them, resulting in autoimmune diseases such as diabetes, multiple sclerosis and arthritis. An organ called the thymus is responsible for educating the immune system, and preventing autoimmune diseases. The proposed project will explore how the thymus develops, and how it teaches the immune system to ignore normal components of the body.
The Role Of Toll Like Receptors In Leukocyte Activation And Adherence In Glomeruli In Auto-immune Glomerulonephritis
Funder
National Health and Medical Research Council
Funding Amount
$82,554.00
Summary
1 in 7 Australians have Kidney disease. Kidney disease tends to be progressive and over 8500 Australians require renal replacement therapy (dialysis). The cost of dialysis from 2004-2010 in Australia will be $ 4.5 billion. Auto-immune disease and Diabetes accounts for nearly 60% of kidney failure. Whilst current regimes exist to treat Kidney disease these are limited because they are deleterious side-effects. Improved understanding of the mechanism of disease will lead to improved treatments.
Immunopathogenesis Of Organ-specific Autoimmune Disease
Funder
National Health and Medical Research Council
Funding Amount
$284,638.00
Summary
The immune system normally protects against invasion by pathogens such as harmful viruses and bacteria. In autoimmune diseases the same mechanisms that are used to protect us are erroneously targeted to our own tissues. Our studies will employ state-of-the art technologies to further our knowledge of this class of diseases and to uncover the normal mechanisms that allow the immune system to differentiate foreign and self components.