Discovery Early Career Researcher Award - Grant ID: DE120102640
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Behavioural foundations of economic design for an uncertain world. The aim of this project is to incorporate behavioural foundations into mechanism design to improve our understanding of economic institutions in incomplete information environments. To accomplish this goal, it considers a framework where agents have reference-dependent preferences and explores implications of this assumption for economic design.
Molecular archaeology: new knowledge from molecular weight distributions of synthetic and natural polymers. This project will lead to new understanding of how natural and synthetic polymers are formed. Examples are the enzymatic processes that produce the subtle architecture of rice grains, and the processes that pose problems for developing new techniques for making novel polymer-based materials. The fundamental scientific knowledge from this project will provide a platform for the future devel ....Molecular archaeology: new knowledge from molecular weight distributions of synthetic and natural polymers. This project will lead to new understanding of how natural and synthetic polymers are formed. Examples are the enzymatic processes that produce the subtle architecture of rice grains, and the processes that pose problems for developing new techniques for making novel polymer-based materials. The fundamental scientific knowledge from this project will provide a platform for the future development of improved materials, and for superior grain varieties for food and industrial use. These advances will be of significant benefit to Australian industry and consumers.Read moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Mechanistic investigation of fluorinated coatings for stone preservation. We will investigate mechanisms governing the synthesis of a latex used for stone preservation. This latex is made from novel and unusual starting materials, and will be the most complex system for which mechanisms have been investigated. We will redesign the synthesis procedure to control particle size and composition of the functional species at the particle surface. This will enable both particle size and surface composi ....Mechanistic investigation of fluorinated coatings for stone preservation. We will investigate mechanisms governing the synthesis of a latex used for stone preservation. This latex is made from novel and unusual starting materials, and will be the most complex system for which mechanisms have been investigated. We will redesign the synthesis procedure to control particle size and composition of the functional species at the particle surface. This will enable both particle size and surface composition to be tailored as desired. The results will be used to investigate the influence of these quantities on interactions between particles and sandstone surfaces. The outcomes will be used by the industrial partner to devise improved protective coatings for stone surfaces in Australian conditions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454052
Funder
Australian Research Council
Funding Amount
$733,595.00
Summary
Tandem Matrix-Assisted Laser Desorption/Ionisation Time-Of-Flight Mass Spectrometer and Robots for High Throughput Proteomics Analysis. This proposal seeks to establish the capacity to perform high-energy tandem mass spectrometry on a high throughput basis, through purchase and coordinated operation of a Matrix-Assisted Laser Desorption/Ionisation - Time of Flight / Time of Flight - Mass Spectrometer and ancillary equipment, to enhance the proteomics expertise, infrastructure and research plans ....Tandem Matrix-Assisted Laser Desorption/Ionisation Time-Of-Flight Mass Spectrometer and Robots for High Throughput Proteomics Analysis. This proposal seeks to establish the capacity to perform high-energy tandem mass spectrometry on a high throughput basis, through purchase and coordinated operation of a Matrix-Assisted Laser Desorption/Ionisation - Time of Flight / Time of Flight - Mass Spectrometer and ancillary equipment, to enhance the proteomics expertise, infrastructure and research plans of a network of institutions from Queensland and New South Wales and their collaborators. Access to such instrumentation is critical to high level achievement in proteomics, a key platform technology for National Research Priorities relating to Frontier Technologies. No comparable instrument currently exists in Australia.Read moreRead less
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less