Identifying Rare Genetic Variants Conferring Susceptibility To Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$293,898.00
Summary
Recently there has been success in identifying common genetic variants that confer susceptibility to multiple sclerosis. The variants that have been discovered so far have modest effects on risk of disease, and only explain a small proportion of familial aggregation of disease. In this study we aim to identify rarer genetic variants that have stronger effects on risk of disease, using new statistical methods and new methods to sequence very large amounts of DNA.
Climate change: bridging the gap between environmental induced phenotypic change, population dynamics, and long-term evolution. It is becoming impossible to ignore the impact of global climate change on organisms around the world from changes in migration, distribution to extinction events - yet there is much to understand. This project examines the role of a changing environment during developmental and its effects on ecological and evolutionary outcomes.
Discovery Early Career Researcher Award - Grant ID: DE230100992
Funder
Australian Research Council
Funding Amount
$426,216.00
Summary
A novel epigenetic clock tool to conserve Australia’s threatened seabirds. The aim is to develop a novel epigenetic technique for the demographic assessment of long-lived seabirds, including albatrosses and petrels, for application to the conservation of 11 threatened species breeding across Australia. A major innovation will be an affordable and fieldwork-friendly technique to demographically fingerprint any population, ending the large amount of guesswork currently necessary in management. The ....A novel epigenetic clock tool to conserve Australia’s threatened seabirds. The aim is to develop a novel epigenetic technique for the demographic assessment of long-lived seabirds, including albatrosses and petrels, for application to the conservation of 11 threatened species breeding across Australia. A major innovation will be an affordable and fieldwork-friendly technique to demographically fingerprint any population, ending the large amount of guesswork currently necessary in management. The outcome is expected to enable (i) scientists and wildlife managers to impute the impact of threats and management activities on seabird populations, allowing quantitative scenario modelling, and (ii) stakeholders to analyse numerous threats and optimise management responses to these through research-based decision-making.Read moreRead less
Cosmic powerhouses: The birth, death, and legacy of black hole jets. This project targets relativistic jets powered by supermassive black holes - the most powerful systems in the Universe. Theoretically, the enormous energies released have a profound influence on how galaxies evolve; empirically, observations reveal signatures of their impact across cosmic time. However, fundamental questions remain about how these jets are triggered and what impact they have on galaxies. The project will addres ....Cosmic powerhouses: The birth, death, and legacy of black hole jets. This project targets relativistic jets powered by supermassive black holes - the most powerful systems in the Universe. Theoretically, the enormous energies released have a profound influence on how galaxies evolve; empirically, observations reveal signatures of their impact across cosmic time. However, fundamental questions remain about how these jets are triggered and what impact they have on galaxies. The project will address these questions using novel supercomputer models of black hole jets in realistic cosmological environments, then confront these predictions with new data from Square Kilometre Array (SKA) pathfinding radio telescopes. This will substantially enhance Australia’s leadership capacity in a strategically important area.Read moreRead less
Carbon in - carbon out: can carbon inputs keep up with losses in peatland? This project aims to quantify the current and predict the future carbon balance of a high altitude, carbon-dense ecosystem, namely sub-alpine grassy peatland, by measuring how environmental variables including experimental warming control the fluxes of carbon and water into and out of the system. In this way, this project will produce new knowledge on the susceptibility of high-altitude peaty soils to climate change. Expe ....Carbon in - carbon out: can carbon inputs keep up with losses in peatland? This project aims to quantify the current and predict the future carbon balance of a high altitude, carbon-dense ecosystem, namely sub-alpine grassy peatland, by measuring how environmental variables including experimental warming control the fluxes of carbon and water into and out of the system. In this way, this project will produce new knowledge on the susceptibility of high-altitude peaty soils to climate change. Expected outcomes include an enhanced ability to predict future carbon accumulation rates and the resilience of the vital water-storage and filtration services provided by these systems. This project will enhance outputs from new infrastructure and assist planning for future flood and drought management across SE Australia.Read moreRead less
How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts an ....How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts and estimates. The observations will also be used to extend known biases in the national gridded precipitation analysis that are a result of the complex mountain terrain. This identification of the physical processes that enhance and redistribute precipitation over the alpine regions across south east Australia and Tasmania will lead to better precipitation estimates and forecasts and better water management.Read moreRead less
Conserving wildlife at landscape-scales. The project aims to conserve threatened wildlife at large scales in unfenced landscapes. Using empirical field experiments in Australia and New Zealand, the project will test how suppressing populations of invasive prey – rabbits – could reduce the effect of invasive predators – cats – on native wildlife. Feral cats threaten biodiversity globally, including Australia and New Zealand. Effective control of cats is difficult at large-scales but rabbit contro ....Conserving wildlife at landscape-scales. The project aims to conserve threatened wildlife at large scales in unfenced landscapes. Using empirical field experiments in Australia and New Zealand, the project will test how suppressing populations of invasive prey – rabbits – could reduce the effect of invasive predators – cats – on native wildlife. Feral cats threaten biodiversity globally, including Australia and New Zealand. Effective control of cats is difficult at large-scales but rabbit control is feasible. The project aims to provide a conceptual approach for biodiversity conservation that can be scaled up to mitigate the effects of invasive predators at large scales globally and allow restoration of ecosystems.Read moreRead less
Building Central Asia: Linking the Growth of Asia to its Exhumation. The consumption of the Tethys Ocean and the associated collision of Gondwana-derived terranes with Eurasia resulted in the uplift of the highest mountain belt on Earth: the Himalayas. However, stresses from this collision zone propagated far into the Eurasian interior by reactivating faults and creating mountain belts along these fault zones. This project aims to map and model how and when fault (re)activation occurred by integ ....Building Central Asia: Linking the Growth of Asia to its Exhumation. The consumption of the Tethys Ocean and the associated collision of Gondwana-derived terranes with Eurasia resulted in the uplift of the highest mountain belt on Earth: the Himalayas. However, stresses from this collision zone propagated far into the Eurasian interior by reactivating faults and creating mountain belts along these fault zones. This project aims to map and model how and when fault (re)activation occurred by integrating multi-method thermochronological and structural data on major Meso-Cenozoic Central Asian fault systems. The resulting time-integrated tectonic model will aid in the understanding of the India-Eurasia collision, the building of the mountainous Central Asian landscape and its influence on the Asian climate.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101116
Funder
Australian Research Council
Funding Amount
$370,159.00
Summary
Adaptations in Tasmanian devil facial tumour disease. This project aims to understand how defence mechanisms against infectious diseases arise and evolve in nature. Infectious diseases exert strong evolutionary pressures on populations, forcing the development of adaptive strategies to fight the costs of infection. The project aims to determine individual differences in response to infection and how these affect population-scale transmission and evolutionary dynamics under natural and managed sc ....Adaptations in Tasmanian devil facial tumour disease. This project aims to understand how defence mechanisms against infectious diseases arise and evolve in nature. Infectious diseases exert strong evolutionary pressures on populations, forcing the development of adaptive strategies to fight the costs of infection. The project aims to determine individual differences in response to infection and how these affect population-scale transmission and evolutionary dynamics under natural and managed scenarios. This is expected to reveal populations’ adaptive capability and resilience against diseases and the effects of management interventions in controlling disease outbreaks and preventing population declines or extinctions.Read moreRead less
Transformation of vegetation by big herbivores, from the Pleistocene to now. The project aims to provide a coherent understanding of the effects of extinct and extant large herbivores on ecosystems over space and time. The structure and distribution of vegetation types is determined not only by climate and soils, but also by the impacts of herbivores and fire as consumers of plant biomass. Recent research has shown how fire shapes the large-scale distribution of vegetation types, but we do not h ....Transformation of vegetation by big herbivores, from the Pleistocene to now. The project aims to provide a coherent understanding of the effects of extinct and extant large herbivores on ecosystems over space and time. The structure and distribution of vegetation types is determined not only by climate and soils, but also by the impacts of herbivores and fire as consumers of plant biomass. Recent research has shown how fire shapes the large-scale distribution of vegetation types, but we do not have an equivalent understanding of the effects of large ground-dwelling herbivores. The project plans to test the effects of such animals on vegetation structure in the Pleistocene, when mega-herbivores were common, and today, and thus to compare the impacts of fire and herbivores on the distribution of vegetation types.Read moreRead less