Micro-disperse sintered nano-diamonds: a new class of versatile adsorbent for high performance liquid chromatography. Nano-diamond is currently recognised amongst researchers as a highly significant material for the development of new technologies in analytical science, diagnostics and nano-technology. Here, sintered nano-diamond, with its many unique properties, will provide a new generation of stationary phases for use in high performance liquid chromatography.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100043
Funder
Australian Research Council
Funding Amount
$389,000.00
Summary
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes inc ....Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes include: interdisciplinary collaborations in new protocols for in-vitro drug development; cell printing technologies; environmental impacts of microplastics; and materials design. Expected benefits include innovative approaches to early stage drug design; improved environmental controls and advances in innovative materials.Read moreRead less
Green sample preparation technologies for analytical chemistry. This project opens new directions for the sample preparation of small molecules, nanoparticles and bacterial cells prior to analysis and will reduce pollution from chemical laboratories. The proposed 'green' analytical chemistry techniques will strengthen the position of Australia as a world-leader in separation science.
On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technol ....On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technology is expected to provide new capability in bioanalysis, proteomics and rapid clinical diagnostics. Future benefits may include new commercial fibre based technologies which could be applied within industrial and clinical laboratories within the next ten years.Read moreRead less
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Carbonaceous adsorbents for ultra-high performance liquid chromatography. This project aims to develop a new generation of mechanically and thermally stable carbon-nanocarbon composite adsorbents for ultra-high-performance liquid chromatography. The structure of adsorbents will be constructed according to advanced core-shell design with non-porous carbon central core and porous shell formed by highly ordered uniform nanocarbon particles. The unique properties of carbon-nanocarbon composite adsor ....Carbonaceous adsorbents for ultra-high performance liquid chromatography. This project aims to develop a new generation of mechanically and thermally stable carbon-nanocarbon composite adsorbents for ultra-high-performance liquid chromatography. The structure of adsorbents will be constructed according to advanced core-shell design with non-porous carbon central core and porous shell formed by highly ordered uniform nanocarbon particles. The unique properties of carbon-nanocarbon composite adsorbents will put liquid chromatography to qualitatively new levels of the separation performance that may open new possibilities for medicine and biodiagnostics. The resulting technology also has a strong potential to be used in other priority areas such as preparation of electrodes and supercapacitors for energy storage devices.Read moreRead less
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Lectin based open tubular micro-reactors for probing protein-protein binding. This project seeks to develop non-invasive technology for the measurement and quantitation of lectin-carbohydrate binding events, in the first instance glycopeptides and glycoproteins. The goal is not only to provide accurate protein-protein association and dissociation constant data within the developed system, but to do so within an enclosed micro-fluidic environment, with the added advantages of also providing ‘trap ....Lectin based open tubular micro-reactors for probing protein-protein binding. This project seeks to develop non-invasive technology for the measurement and quantitation of lectin-carbohydrate binding events, in the first instance glycopeptides and glycoproteins. The goal is not only to provide accurate protein-protein association and dissociation constant data within the developed system, but to do so within an enclosed micro-fluidic environment, with the added advantages of also providing ‘trap and release’ extraction capabilities, and being easily coupled to both chromatographic and mass spectrometry systems. Read moreRead less
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A field-portable comprehensive multidimensional gas chromatograph. This project represents an innovative new direction for chemical analysis of environmental contaminants with further case studies planned in a number of diverse application areas. State-of-the-art field-portable instrumentation will be developed to bridge the capability gap for performing in-field analysis of highly complex samples.