ARC Centre of Excellence for Children and Families over the Life Course. New solutions are needed to underpin the Australian social ideal of a fair go, and to drive future global economic productivity. The Australian Productivity Commission identifies deep and persistent disadvantage as a significant problem in Australia given the failure of growing national prosperity over the past two decades to benefit underprivileged Australians. Social disadvantage is a global challenge. This Centre will ad ....ARC Centre of Excellence for Children and Families over the Life Course. New solutions are needed to underpin the Australian social ideal of a fair go, and to drive future global economic productivity. The Australian Productivity Commission identifies deep and persistent disadvantage as a significant problem in Australia given the failure of growing national prosperity over the past two decades to benefit underprivileged Australians. Social disadvantage is a global challenge. This Centre will advance basic, applied and translational research to reduce intergenerational and long-term disadvantage. Through the maturation of longitudinal datasets and advanced data integration we can follow the journeys of Australian families over generations and across the life course. This data will provide evidence for new policies and make a real difference to the lives of children and families.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Pathways to social cohesion and social change: opinion-based groups and the dynamic formation of identities. This project will update the understanding of political conflict by exploring groups based around shared opinions. It will show that groups are likely to be more successful in their political campaigns when they tie their causes to national and other positive identifies.
Megalithic Connections: Imperilled Cultural Heritage in Laos and India. This interdisciplinary project aims to document and explore the cultural connections between the geographically disparate megalithic cultures of Laos and India and create an enduring digital record of these threatened cultural assets. Integrating archaeological science and pioneering data capture technologies, the project will create globally significant new knowledge; advance heritage management processes including transfer ....Megalithic Connections: Imperilled Cultural Heritage in Laos and India. This interdisciplinary project aims to document and explore the cultural connections between the geographically disparate megalithic cultures of Laos and India and create an enduring digital record of these threatened cultural assets. Integrating archaeological science and pioneering data capture technologies, the project will create globally significant new knowledge; advance heritage management processes including transferrable exploratory technologies; and help underpin economic, social and cultural benefit in these regions. With an increasing awareness of the need to conserve global cultural assets, Australia will take the lead in developing breakthrough technological solutions and new cross-country research and practitioner capability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100054
Funder
Australian Research Council
Funding Amount
$1,341,398.00
Summary
Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant ad ....Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant advantage for chemists, physicists, biologists, geologists, and engineers who rely on detailed structural knowledge to rationally optimise the properties of their compounds, from pharmaceutical activity to carbon capture to superconductivity, to the substantial benefit of multiple national priority areas.Read moreRead less
Putting death in its place. The project aims to link 890,000 population records to place of residence from 1838 to 1930, to examine the relationships between where people live, mortality, life expectancy and health. Where people live impacts their life-course outcomes. Using novel matching techniques, the project expects to identify intergenerational changes and the spatial dynamics of inequality and social mobility. Expected outcomes include the creation of a public resource of linked data and ....Putting death in its place. The project aims to link 890,000 population records to place of residence from 1838 to 1930, to examine the relationships between where people live, mortality, life expectancy and health. Where people live impacts their life-course outcomes. Using novel matching techniques, the project expects to identify intergenerational changes and the spatial dynamics of inequality and social mobility. Expected outcomes include the creation of a public resource of linked data and a better understanding of long-run health and inequality. These should provide economic and social benefits by informing policy aimed at contemporary social and health challenges, enhancing our understanding of Australian history, and developing public resources.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100166
Funder
Australian Research Council
Funding Amount
$626,800.00
Summary
High-throughput camera system for biological cryo-electron microscopy. Visualising the structure of biological macromolecules such as proteins and other subcellular components is critical to understand the fundamentals of life. The integration of the Gatan K3 high-throughput camera system with one of the most advanced cryo-electron microscopy facilities in Australia and the Southern Hemisphere will transform the capacity of Australian researchers to study the world around us at the molecular det ....High-throughput camera system for biological cryo-electron microscopy. Visualising the structure of biological macromolecules such as proteins and other subcellular components is critical to understand the fundamentals of life. The integration of the Gatan K3 high-throughput camera system with one of the most advanced cryo-electron microscopy facilities in Australia and the Southern Hemisphere will transform the capacity of Australian researchers to study the world around us at the molecular detail needed to advance innovative research. The addition of this equipment to the University of Wollongong's research facility Molecular Horizons will result in a step change in the areas of bionanotechnology, advanced manufacturing, diagnostics, and many other areas at the interface of biology, chemistry and physics.Read moreRead less
Building An Indigenist Health Humanities Collective. This proposal aims to develop Indigenist Health Humanities as a new and innovative field of inquiry, building an intellectual collective capable of bridging the knowledge gap that hinders current efforts to close the gap in Indigenous health inequality. Bringing together health and the humanities through the particularity of Indigenous scholarship, a deeper understanding of the human experience of health will be developed alongside a greater u ....Building An Indigenist Health Humanities Collective. This proposal aims to develop Indigenist Health Humanities as a new and innovative field of inquiry, building an intellectual collective capable of bridging the knowledge gap that hinders current efforts to close the gap in Indigenous health inequality. Bringing together health and the humanities through the particularity of Indigenous scholarship, a deeper understanding of the human experience of health will be developed alongside a greater understanding of the enablers to building a transdisciplinary collective of Indigenous health researchers. The potential benefits include a more sustainable, relational and ethical approach to advancing new knowledge, advancing research careers and advancing health outcomes for Indigenous people. Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
What makes a community resilient? Examining changes in the adaptive capacities of Brisbane suburbs before and after the 2011 flood. This project will be the first study to examine the key community processes and structures associated with community resilience both before and after the 2011 Brisbane floods. Drawing on a longitudinal study of Brisbane suburbs, it will critically assess the conditions under which suburban communities respond to and recover from a major disaster.