The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Humanitarian migrants' settlement in Australia: A longitudinal study. Current evidence suggests that humanitarian migrants settle less successfully than other immigrants both economically and socially. This project aims to examine the causal mechanisms and pathways to economic, sociocultural and political settlement outcomes of humanitarian migrants to Australia. This project expects to generate new knowledge in the area of humanitarian migrants’ settlement by using nationally representative dat ....Humanitarian migrants' settlement in Australia: A longitudinal study. Current evidence suggests that humanitarian migrants settle less successfully than other immigrants both economically and socially. This project aims to examine the causal mechanisms and pathways to economic, sociocultural and political settlement outcomes of humanitarian migrants to Australia. This project expects to generate new knowledge in the area of humanitarian migrants’ settlement by using nationally representative data and cutting-edge longitudinal techniques.Expected outcomes include enhanced research capacity in causal methods, interdisciplinary and institutional collaborations, and evidence-based social policy for humanitarian migrants, significantly benefitting humanitarian migrants directly and society more broadly. Read moreRead less
The emotional register of liberal culture in the long nineteenth century. This project aims to advance our understanding of liberal culture, a concept central to the humanities and to modern social and political discourse. It will address the problem of liberalism's perceived rationalism by investigating the role of emotion as a core characteristic of liberal culture during its formation and subsequent development over the course of the long nineteenth century. The project will focus on periodic ....The emotional register of liberal culture in the long nineteenth century. This project aims to advance our understanding of liberal culture, a concept central to the humanities and to modern social and political discourse. It will address the problem of liberalism's perceived rationalism by investigating the role of emotion as a core characteristic of liberal culture during its formation and subsequent development over the course of the long nineteenth century. The project will focus on periodicals as a vital medium for the cultivation and dissemination of progressive liberal ideas and values, as well as for the expression and discussion of the emotions. The project will benefit scholars in political, literary, and cultural studies and contribute to current debates in Australia about liberal culture and its sustainability.Read moreRead less
Transforming charity to reduce persistent poverty. This project aims to produce empirical knowledge to assist charities to reduce persistent poverty in Australia. In Australia people in poverty use charity to subsidise limited incomes and survive on a day-to-day basis. Recently charities are expected to assist in disrupting poverty in addition to poverty relief. However there is limited knowledge about how charities work with people who are poor and how they can change to work better. This proje ....Transforming charity to reduce persistent poverty. This project aims to produce empirical knowledge to assist charities to reduce persistent poverty in Australia. In Australia people in poverty use charity to subsidise limited incomes and survive on a day-to-day basis. Recently charities are expected to assist in disrupting poverty in addition to poverty relief. However there is limited knowledge about how charities work with people who are poor and how they can change to work better. This project expects to provide knowledge that governments, social service providers, and charities can use to transform their work with people in poverty. Read moreRead less
Megalithic Connections: Imperilled Cultural Heritage in Laos and India. This interdisciplinary project aims to document and explore the cultural connections between the geographically disparate megalithic cultures of Laos and India and create an enduring digital record of these threatened cultural assets. Integrating archaeological science and pioneering data capture technologies, the project will create globally significant new knowledge; advance heritage management processes including transfer ....Megalithic Connections: Imperilled Cultural Heritage in Laos and India. This interdisciplinary project aims to document and explore the cultural connections between the geographically disparate megalithic cultures of Laos and India and create an enduring digital record of these threatened cultural assets. Integrating archaeological science and pioneering data capture technologies, the project will create globally significant new knowledge; advance heritage management processes including transferrable exploratory technologies; and help underpin economic, social and cultural benefit in these regions. With an increasing awareness of the need to conserve global cultural assets, Australia will take the lead in developing breakthrough technological solutions and new cross-country research and practitioner capability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100054
Funder
Australian Research Council
Funding Amount
$1,341,398.00
Summary
Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant ad ....Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant advantage for chemists, physicists, biologists, geologists, and engineers who rely on detailed structural knowledge to rationally optimise the properties of their compounds, from pharmaceutical activity to carbon capture to superconductivity, to the substantial benefit of multiple national priority areas.Read moreRead less
Building An Indigenist Health Humanities Collective. This proposal aims to develop Indigenist Health Humanities as a new and innovative field of inquiry, building an intellectual collective capable of bridging the knowledge gap that hinders current efforts to close the gap in Indigenous health inequality. Bringing together health and the humanities through the particularity of Indigenous scholarship, a deeper understanding of the human experience of health will be developed alongside a greater u ....Building An Indigenist Health Humanities Collective. This proposal aims to develop Indigenist Health Humanities as a new and innovative field of inquiry, building an intellectual collective capable of bridging the knowledge gap that hinders current efforts to close the gap in Indigenous health inequality. Bringing together health and the humanities through the particularity of Indigenous scholarship, a deeper understanding of the human experience of health will be developed alongside a greater understanding of the enablers to building a transdisciplinary collective of Indigenous health researchers. The potential benefits include a more sustainable, relational and ethical approach to advancing new knowledge, advancing research careers and advancing health outcomes for Indigenous people. Read moreRead less
Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of mul ....Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of multi-disciplinary approaches, ranging from future climate models, historical satellite data to in-field experimentation to fill fundamental knowledge gaps in our understanding of coral bleaching recovery and delivery a variety of management and stakeholder relevant outputs.Read moreRead less
Beyond migration and diffusion: The prehistoric mobility of people & ideas. The project plans to build on the strength of current collaborations between archaeologists and geochemists to ask novel questions about the movement of people and ideas in prehistory. The project plans to examine spatial and temporal patterns in population mobility to clarify their relationship with the appearance of new and exotic materials, technologies and practices. The project focuses on the ways in which the movem ....Beyond migration and diffusion: The prehistoric mobility of people & ideas. The project plans to build on the strength of current collaborations between archaeologists and geochemists to ask novel questions about the movement of people and ideas in prehistory. The project plans to examine spatial and temporal patterns in population mobility to clarify their relationship with the appearance of new and exotic materials, technologies and practices. The project focuses on the ways in which the movement of individuals and groups of people is both an instigator and a response to sociocultural change, using both key European and Pacific Island examples, to help build a comparative archaeology of phenomena of rapid social and economic change, with pertinence to general theories of innovation and adoption.Read moreRead less
The First Polynesians: Their Origins, Lifeways and Environmental Challenges. This project uses an interdisciplinary approach to examine the biological, cultural and environmental factors underpinning the Polynesian people through a study of their ancient homeland in Tonga. Early Polynesian society developed 2650-2350 years ago, but little is known about the people, their culture and how sea-level fall impacted subsistence and settlement. The proposed study’s goal is to fill this gap in human kno ....The First Polynesians: Their Origins, Lifeways and Environmental Challenges. This project uses an interdisciplinary approach to examine the biological, cultural and environmental factors underpinning the Polynesian people through a study of their ancient homeland in Tonga. Early Polynesian society developed 2650-2350 years ago, but little is known about the people, their culture and how sea-level fall impacted subsistence and settlement. The proposed study’s goal is to fill this gap in human knowledge about our Pacific neighbours using a unique skeletal assemblage, excavated cultural remains and advanced mapping of palaeo-sea-level markers that will improve understanding of the impact of environmental change on human societies in our region.Read moreRead less