A Randomised Controlled Trial Of Personalised Goal-directed Activity To Treat Agitation In Dementia
Funder
National Health and Medical Research Council
Funding Amount
$310,077.00
Summary
We will test by means of a randomised controlled trial the effectiveness of personalised, goal-directed activities in reducing agitated behaviour in aged care residents with dementia. Evidence suggests that treatments work best when adapted to people's interest, skills and backgrounds. Our activities require no special equipment and there is no need to exclude people with limited language skills. The study will be controlled to ensure that benefits are not due just to social interaction.
Sydney Multisite Intervention Of LaughterBosses And ElderClowns (SMILE): An RCT Of Humour Therapy In Residential Care
Funder
National Health and Medical Research Council
Funding Amount
$852,237.00
Summary
Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE) is a trial of humour therapy. About 400 residents from 36 hostels and nursing homes will be randomly assigned to receive the SMILE treatment or usual care. ElderClowns will visit weekly, and staff volunteers will be trained to be LaughterBosses and bring humour to daily care routines. SMILE will evaluate whether humour therapy improves resident quality-of-life and mood, and reduces staff burnout and turnover.
Insight And Cognitive Decline In Older Adults With Mild Cognitive Impairment
Funder
National Health and Medical Research Council
Funding Amount
$399,600.00
Summary
Australia's population is aging rapidly and so is the frequency of age-related disorders. Dementia is one of the most frequent mental health disorders and one of the leading causes of years of life lost due to disability in Australia. Therefore it is important to be able to identify older adults at high risk of developing dementia in order to be able to introduce preventative strategies. One important risk factor for cognitive decline is the presence of mild cognitive impairment (MCI) in older a ....Australia's population is aging rapidly and so is the frequency of age-related disorders. Dementia is one of the most frequent mental health disorders and one of the leading causes of years of life lost due to disability in Australia. Therefore it is important to be able to identify older adults at high risk of developing dementia in order to be able to introduce preventative strategies. One important risk factor for cognitive decline is the presence of mild cognitive impairment (MCI) in older adults who complain about memory problems. However many subjects with MCI do not develop dementia and it remains a challenge to identify those with pre-dementia amongst those with MCI. The purpose of this study is to investigate whether reduced awareness of cognitive impairment is a better predictor of cognitive decline and dementia than having memory complaints . To investigate the association of reduced awareness and cognitive decline, 80 participants with MCI and 80 healthy controls will be followed over a period of 24 months. Awareness will be measured and compared to information on cognitive and functional impairment given by the participant and an informant. Additionally, information from neuroimaging and laboratory studies will be collected to determine it's interaction with reduced awareness.Read moreRead less
A Randomised Clinical Trial Of Physical Activity For The Treatment Of Older Adults With Mild Cognitive Impairment
Funder
National Health and Medical Research Council
Funding Amount
$280,250.00
Summary
Australia's population is aging rapidly and so is the frequency of age-related diseases. Dementia and depression are the most frequent mental health disorders of older people. They are also the leading causes of years of life lost due to disability in Australia. The results of recent studies have shown that memory difficulties and dementia are associated with potentially modifiable risk factors, such as physical activity. The purpose of this study is to investigate whether a physical activity pr ....Australia's population is aging rapidly and so is the frequency of age-related diseases. Dementia and depression are the most frequent mental health disorders of older people. They are also the leading causes of years of life lost due to disability in Australia. The results of recent studies have shown that memory difficulties and dementia are associated with potentially modifiable risk factors, such as physical activity. The purpose of this study is to investigate whether a physical activity program for older adults decreases cognitive decline and conversion to dementia in a population at risk: mild cognitive impairment (MCI). 168 subjects with MCI will be randomised (by chance, like the flip of a coin) to either the intervention program of physical activity or usual care - their cognitive (such as memory) performance will be compared at the end of 24 months.Read moreRead less
Is Hip Fracture Rehabilitation Cost Effective In Residential Care? A Randomised Controlled Trial Of Rehabilitation
Funder
National Health and Medical Research Council
Funding Amount
$137,970.00
Summary
Some of the frailest members of our community live in nursing homes and a hip fracture can be devastating to a person with dementia as it can leave them permanently unable to walk. We don't know how best to promote recovery when they break their hips. At present there is an assumption that rehabilitation at this stage of life is not worthwhile but this study will test whether the benefits outweigh the costs. We will test whether an assessment by a geriatrician and rehabilitation improves walking ....Some of the frailest members of our community live in nursing homes and a hip fracture can be devastating to a person with dementia as it can leave them permanently unable to walk. We don't know how best to promote recovery when they break their hips. At present there is an assumption that rehabilitation at this stage of life is not worthwhile but this study will test whether the benefits outweigh the costs. We will test whether an assessment by a geriatrician and rehabilitation improves walking, independence and quality of life.Read moreRead less
A Population Based Study Of The Use Of Acute Hospital Services By Elderly People Living In Residential Care.
Funder
National Health and Medical Research Council
Funding Amount
$127,000.00
Summary
This project will be the first population based Australian study to describe the pattern of utilisation of acute hospital services by elderly people living in residential care. It will provide much needed information on which to base health policy decisions relating to the acute care needs of the most frail elderly members of our community. Within a context of an ageing demographic profile of the Australian population, it is essential that the dynamic interplay between acute care services and th ....This project will be the first population based Australian study to describe the pattern of utilisation of acute hospital services by elderly people living in residential care. It will provide much needed information on which to base health policy decisions relating to the acute care needs of the most frail elderly members of our community. Within a context of an ageing demographic profile of the Australian population, it is essential that the dynamic interplay between acute care services and the residential aged-care sector be elucidated, both for current service provision and for better prediction of future service requirements. This study will make use of existing linked health data sources in WA to achieve the following aims: 1. To provide health service planners with information about the rates, patterns, causes, outcomes and costs of acute emergency department and in-patient hospital services for elderly persons living in residential care in Perth, Western Australia. 2. To develop a population model to determine future acute hospital requirements for elderly persons living in residential care. 3. To estimate the potential impact of alternate modes of integration of acute and long-term care on the utilisation of acute hospital services by hostel and nursing home residents.Read moreRead less
Gastric, Small Intestinal And Cardiovascular Mechanisms Of Postprandial Hypotension.
Funder
National Health and Medical Research Council
Funding Amount
$701,521.00
Summary
A fall in blood pressure after a meal (known as postprandial hypotension) is an important clinical problem, particularly in the elderly, and is associated with an increase in the incidence of falls, stroke, as well as mortality. The mechanisms responsible for postprandial hypotension are not well understood and current therapies are less than optimal. The studies proposed in the current application have important implications for the management of postprandial hypotension.
Pathophysiology Of Postprandial Hypotension In The Elderly - Role Of Gastric And Small Intestinal Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$471,176.00
Summary
A fall in blood pressure after a meal (known as postprandial hypotension) is an important clinical problem, particularly in the elderly, occurring in ~50% of nursing home residents and ~30% of healthy older subjects. Postprandial hypotension is associated with a substantial increase in the incidence of falls, stroke, as well as mortality. The mechanisms responsible for the fall in blood pressure after a meal are not well understood, although changes in gastrointestinal blood flow and the release ....A fall in blood pressure after a meal (known as postprandial hypotension) is an important clinical problem, particularly in the elderly, occurring in ~50% of nursing home residents and ~30% of healthy older subjects. Postprandial hypotension is associated with a substantial increase in the incidence of falls, stroke, as well as mortality. The mechanisms responsible for the fall in blood pressure after a meal are not well understood, although changes in gastrointestinal blood flow and the release of gut hormones, have been implicated. While ingestion of carbohydrate, particularly glucose, has been reported to decrease blood pressure most potently, there is inadequate and conflicting information about the effects of other nutrients such as fat and protein. Current therapies are less than optimal. Studies by our research group have established that the fall in blood pressure in response to meals is related to the rate at which nutrients enter the small intestine ie the fall in blood pressure is greater when the stomach empties more quickly. In contrast, gastric distension reduces the fall in blood pressure. Hence, treatment could be directed at facilitating gastric distension and-or slowing the rate of nutrient delivery into the small intestine. Our previous studies have not included any assessment of changes in blood flow to the gut after meals, or of the interaction between gastric distension and small intestinal mechanisms, and have involved healthy older subjects and patients with type 2 (non-insulin dependent) diabetes rather than individuals with known postprandial hypotension. We now have the capacity to measure blood flow in the gut with ultrasound. The studies proposed in the current application represent a logical development from our previous work and have important implications for the management of postprandial hypotension.Read moreRead less
A Controlled Trial Of Topical Lavender Oil As A Treatment Of Behavioural Symptoms Of Dementia
Funder
National Health and Medical Research Council
Funding Amount
$211,179.00
Summary
Many nursing home residents with dementia have challenging behavioural symptoms. This study will test if pure lavender oil, when massaged onto the forearms of confused nursing home residents, relieves their agitation better than a placebo oil. Researchers will measure residents' behaviour directly and will not be aware which oil is being applied.