The study of wear debris using advanced technologies. A large portion of the operating cost of machinery is associated with wear due to the interaction between moving surfaces, which generates wear particles as by-products. The wear particles thus carry information regarding the wearing process, and can be used to assess the machine's condition and further facilitate failure prediction and minimise maintenance. This project will explore the mechanisms and possible influence of corrosion on the w ....The study of wear debris using advanced technologies. A large portion of the operating cost of machinery is associated with wear due to the interaction between moving surfaces, which generates wear particles as by-products. The wear particles thus carry information regarding the wearing process, and can be used to assess the machine's condition and further facilitate failure prediction and minimise maintenance. This project will explore the mechanisms and possible influence of corrosion on the wearing process. A new methodology will be developed to quantify the wearing process. This research will significantly advance our understanding with respect to wear and provide innovative means for identifying wear mechanisms/phases.Read moreRead less
Epigenetic and biomarker approaches to improving dairy cow fertility. The dairy industry will not deliver sustainable higher productivity unless the reproductive performance of dairy cows is significantly improved. This expected outcome will be achieved via the identification of epigenetic and protein biomarkers of improved fertility that will be used to develop superior breeding stock. Caruncular and intercaruncular tissues and blood have been obtained from both fertile (New Zealand Holstein-Fr ....Epigenetic and biomarker approaches to improving dairy cow fertility. The dairy industry will not deliver sustainable higher productivity unless the reproductive performance of dairy cows is significantly improved. This expected outcome will be achieved via the identification of epigenetic and protein biomarkers of improved fertility that will be used to develop superior breeding stock. Caruncular and intercaruncular tissues and blood have been obtained from both fertile (New Zealand Holstein-Friesian) and sub-fertile (North American Holstein-Friesian) cows within pasture-based dairying systems that include seasonal calving and subclinical uterine inflammation (associated with poor reproductive performance). Determinations will be conducted using deep parallel (next generation) sequencing and mass spectrometry.Read moreRead less
Optimum design of hydraulic structures in rural and urban Australia: dealing with floods and droughts. Australia's long-term forecast suggests the occurrence of longer and more frequent droughts, and more intense flood events. The project will study the fundamental hydrodynamic processes in hydraulic structures and aims to develop new innovative designs derived from process based approach for optimum operation in rural and urban Australia.
BIOCATALYSTS MINED FROM CYTOCHROME P450 LIBRARIES: AN INNOVATIVE TOOL FOR ACCELERATING DRUG DEVELOPMENT. The cytochrome P450s (P450s) are a family of enzymes that are perhaps the most versatile biological catalysts known. DNA shuffling is an emerging technique that takes the genes encoding families of enzymes and creates libraries of catalysts with both improved and novel properties. We will obtain proof of concept that shuffled P450 libraries can be screened and optimized for use as biocatalys ....BIOCATALYSTS MINED FROM CYTOCHROME P450 LIBRARIES: AN INNOVATIVE TOOL FOR ACCELERATING DRUG DEVELOPMENT. The cytochrome P450s (P450s) are a family of enzymes that are perhaps the most versatile biological catalysts known. DNA shuffling is an emerging technique that takes the genes encoding families of enzymes and creates libraries of catalysts with both improved and novel properties. We will obtain proof of concept that shuffled P450 libraries can be screened and optimized for use as biocatalysts in drug development. The methodologies developed here will overcome two critical bottlenecks in current drug development: the optimisation and metabolic profiling of new drug candidates. This will yield important benefits in accelerating the optimisation and safety testing of drugs under development.Read moreRead less
Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. Enzymes are currently being used to treat runoff water that is contaminated with OPs. The same enzymes also have the potential to aid in the treatment of OP poison ....Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. Enzymes are currently being used to treat runoff water that is contaminated with OPs. The same enzymes also have the potential to aid in the treatment of OP poisoning. However, OP degrading enzymes could be improved in many ways - we will evolve these enzymes to enhance their catalytic properties - to enable them to act more efficiently on an increased number of OPs. Read moreRead less
Identification of at-risk transition cows: Use of exosomal biomarkers. This project aims to improve the early diagnosis of cows at risk of infectious disease and debilitating metabolic syndromes. Animal health and longevity are pillars of the dairy industry. The risk of death is up to 6 times greater during the transition from pregnancy to lactation, making this ‘transition period’ the time for detection and intervention. If successful, this project will permit the focus of resources on high ris ....Identification of at-risk transition cows: Use of exosomal biomarkers. This project aims to improve the early diagnosis of cows at risk of infectious disease and debilitating metabolic syndromes. Animal health and longevity are pillars of the dairy industry. The risk of death is up to 6 times greater during the transition from pregnancy to lactation, making this ‘transition period’ the time for detection and intervention. If successful, this project will permit the focus of resources on high risk cows and reduce poor outcomes: lower milk production, involuntary culling and increased cow maintenance costs. Within this overall objective, a cost-effective project design will leverage partner facilities and existing networks to translate findings to farm use, thereby clearly delivering economic value.Read moreRead less
Metabolic engineering of sugarcane: production of a biodegradable bioplastic as a test-case. The aim of this project is to produce a commercially valuable bioplastic called PHB in transgenic sugarcane. This bioplastic has similar properties to petrochemically produced polypropylene, but is fully biodegradable. PHB has been produced in the model plant Arabidopsis thaliana at commercially viable levels. The expected outcome of high-level production of PHB in sugarcane would have significant ben ....Metabolic engineering of sugarcane: production of a biodegradable bioplastic as a test-case. The aim of this project is to produce a commercially valuable bioplastic called PHB in transgenic sugarcane. This bioplastic has similar properties to petrochemically produced polypropylene, but is fully biodegradable. PHB has been produced in the model plant Arabidopsis thaliana at commercially viable levels. The expected outcome of high-level production of PHB in sugarcane would have significant benefits to the Australian sugar industry, the rural economy, and the Australian environment.Read moreRead less
Condition-based maintenance optimisation for Australian sugar industry. The aim of this project is to develop innovative methodologies for the implementation of condition-based maintenance in the sugar milling industry. This is designed to optimise the allocation of limited maintenance resources and to significantly reduce the $350 million spent on maintenance in the industry each year. New methodologies will account for the seasonality of production and the complexity of allocating limited main ....Condition-based maintenance optimisation for Australian sugar industry. The aim of this project is to develop innovative methodologies for the implementation of condition-based maintenance in the sugar milling industry. This is designed to optimise the allocation of limited maintenance resources and to significantly reduce the $350 million spent on maintenance in the industry each year. New methodologies will account for the seasonality of production and the complexity of allocating limited maintenance resources across numerous equipment items and different production sites. The intended outcome of the project will improve the efficiency of maintenance and hence the global competitiveness of the Australian sugar industry.Read moreRead less
Modification of lignin biosynthesis in sugarcane for the improved efficiency of pre-treatment in ethanol production. Sugarcane is one of Australia's most important rural industries. However, as a single product industry, declining sugar prices threaten the industry's long term economic sustainability unless alternative markets for sugarcane are created. Utilising the sugarcane waste for cellulosic ethanol would provide a new revenue stream, injecting life into the Australian sugarcane industry. ....Modification of lignin biosynthesis in sugarcane for the improved efficiency of pre-treatment in ethanol production. Sugarcane is one of Australia's most important rural industries. However, as a single product industry, declining sugar prices threaten the industry's long term economic sustainability unless alternative markets for sugarcane are created. Utilising the sugarcane waste for cellulosic ethanol would provide a new revenue stream, injecting life into the Australian sugarcane industry. In addition, cellulosic ethanol from sugarcane has the potential to substantially decrease the cost of biofuel production and significantly reduce greenhouse gas emissions. The research proposed here will advance our ability to improve sugarcane through biotechnology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100213
Funder
Australian Research Council
Funding Amount
$335,000.00
Summary
Optimising the National Benefits From Restoring Environmental Water Flows. The project plans to evaluate strategies that may maximise the national benefits from restoring environmental flows in Australia’s Murray–Darling Basin (MDB). MDB water supply is characterised by prolonged droughts and flood events, and future climatic projections anticipate that these water supply events will intensify. As the uncertainty of future water supply increases, it is important that the volume of water provided ....Optimising the National Benefits From Restoring Environmental Water Flows. The project plans to evaluate strategies that may maximise the national benefits from restoring environmental flows in Australia’s Murray–Darling Basin (MDB). MDB water supply is characterised by prolonged droughts and flood events, and future climatic projections anticipate that these water supply events will intensify. As the uncertainty of future water supply increases, it is important that the volume of water provided by the portfolio of water rights is known. By examining how decision-makers adapt to water supply uncertainty, optimal management strategies could be determined for watering key ecological assets, trading water between irrigators and the government; and private and public investments.Read moreRead less