Rates, Patterns And Determinants Of Alcohol’s Harm To Others: A Cross-national Comparative Study
Funder
National Health and Medical Research Council
Funding Amount
$305,856.00
Summary
Alcohol causes harms to drinkers, and others around them, including spouses, children, family, friends, workmates and strangers. Australian and New Zealand work on alcohol’s harm to others is being replicated by the WHO in 7 countries (Chile, Nigeria, Sri Lanka, India, Thailand, Laos and Vietnam). We aim to analyse datasets from nine countries and compare the magnitude and patterning of problems across and within cultures – identifying opportunities for reducing harm from others’ drinking.
Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using pre-clinical models to identify and characterize a new brain system implicated in drug-seeking.
Young Onset Colorectal Cancer: Genetics Pathology And Environment
Funder
National Health and Medical Research Council
Funding Amount
$439,180.00
Summary
There has been a steady increase since 2002, in the age-standardised incidence of CRC in males under 45 years in Australia, contrasting with the stabilisation in incidence of CRC in males of age 45 years and over. Persons under 50 years are not routinely screened unless they have a significant family history of CRC. Young-onset rectal cancer is associated with late presentations and with a higher mortality. This proposal will address the possible risk factors for young-onset CRC.
Driving Change: Using Emergency Department Data To Reduce Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,468,026.00
Summary
The proposed project is a system change within partner emergency departments, providing them the information and tools to act on both risky alcohol consumption in individual patients and the sources of alcohol in the community which cause the harm they experience. Most importantly, the proposed public health interventions act as a tool for emergency departments to regularly raise awareness with the public and policymakers regarding the impact of alcohol on patients, clinicians and hospitals.
A Randomised Controlled Trial Of Cognitive Bias Modification Training During Early Recovery From Alcohol Dependence
Funder
National Health and Medical Research Council
Funding Amount
$531,685.00
Summary
Relapse to alcohol dependence often occurs within days of detoxification, partly because alcohol-dependent people are easily triggered to approach alcohol-related cues. Computerised “brain-training” programs may reduce this “approach bias”, reducing risk of relapse. We aim to conduct a multi-site trial testing the effects of this training on alcohol relapse, and to estimate the savings to the health care system that could be achieved by conducting this treatment during inpatient detoxification.
Improving Adolescent Gate-keeping And Help-seeking For Risky Drinking And Depression: A Cluster Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$655,495.00
Summary
Young people with mental health and substance use problems are reluctant to seek help. There is a significant gap in health promotion activities which specifically target help-seeking skills, particularly teaching friends to help friends to access treatment early. This project seeks to demonstrate the efficacy of a school-based intervention that focuses on improving adolescent gate-keeping and help-seeking skills for risky drinking and depression, using a cluster randomised controlled design.
The R2C Program: A Randomised Controlled Trial Of A Telephone-based Intervention For Alcohol Misuse
Funder
National Health and Medical Research Council
Funding Amount
$727,611.00
Summary
Despite high rates of problem drinking in Australia, few seek help due to stigma and a range of other barriers. In this project, we will conduct a randomised controlled trial to examine the effectiveness of a standalone telephone-delivered intervention, incorporating low-cost, structured, and integrated psychosocial support, to reduce harmful alcohol use and associated psychological morbidity in non-treatment-seeking problem drinkers.
Genetic and environmental basis for endosperm hardness in malting barley. Barleys with a hard endosperm do not malt as well as other barleys, leading to under-modified malt. While malts may appear to be satisfactory by bulk chemical analysis, even relatively small amounts of under-modified malt causes problems in the brewing industry, such as slow filtration rates and increasing haze formation. We aim to examine two new procedures potentially useful in determining heterogeneity in barley hardn ....Genetic and environmental basis for endosperm hardness in malting barley. Barleys with a hard endosperm do not malt as well as other barleys, leading to under-modified malt. While malts may appear to be satisfactory by bulk chemical analysis, even relatively small amounts of under-modified malt causes problems in the brewing industry, such as slow filtration rates and increasing haze formation. We aim to examine two new procedures potentially useful in determining heterogeneity in barley hardness by examining single kernels, and investigating the role of barley variety and growing conditions on hardness.This project will aid in the production and selection of more uniform barleys for the malting and brewing industries.Read moreRead less
Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce ....Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
A new biophysical approach to understanding self-assembly of dairy proteins in real time in complex systems of industrial importance. The study seeks to understand the molecular basis of self-assembly (aggregation and gelation) of dairy proteins during thermal processing of dairy products. This will involve direct determination, in real time, of the extent, rate and degree of reversibility of the changes that take place. These include changes in the composition, structure and stability of the ca ....A new biophysical approach to understanding self-assembly of dairy proteins in real time in complex systems of industrial importance. The study seeks to understand the molecular basis of self-assembly (aggregation and gelation) of dairy proteins during thermal processing of dairy products. This will involve direct determination, in real time, of the extent, rate and degree of reversibility of the changes that take place. These include changes in the composition, structure and stability of the casein micelles, changes in properties such as pH and pCa and changes such as the denaturation of b-lactoglobulin and its binding to k -casein. The purpose of the study is to provide the scientific base for improving the consistency of manufactured dairy products and for developing new food ingredients with new functionalities thus opening up new opportunities for the dairy industry.Read moreRead less