Salt (sodium) is an essential electrolyte. Our convincing and complementary findings provide compelling evidence for a link between evolutionarily ancient “instincts” and substance abuse. This proposal is translational, including studies in opiate dependent humans. Our studies will establish how and where in the brain endogenous opioids are implicated in the gratification of salt appetite, how salt appetite is altered in opiate dependency and if salt appetite recovers following opiate withdrawal
An inability to resist a temptation or repeated failures of self-regulation can lead to 'impulsive' and 'compulsive' behaviours that relate to a host of personal and social problems (eg., excessive eating, gambling, and substance use). Despite this, very little research has studied the neural and psychological underpinnings of these behaviours. My research will take advantage of recent innovations and approaches to fill this void and have implications for diagnosis and treatment.
The central nucleus of the amygdala and alcohol-seeking behaviour. Alcohol abuse and alcoholism is a significant problem in Australia (and throughout the world). However, pharmacological interventions remain limited due to our poor understanding of the neural networks underlying addictive processes. These experiments will explain how the positive rewarding and negative reinforcing aspects of alcohol are transduced within the brain. We believe that our research will facilitate the ability to trea ....The central nucleus of the amygdala and alcohol-seeking behaviour. Alcohol abuse and alcoholism is a significant problem in Australia (and throughout the world). However, pharmacological interventions remain limited due to our poor understanding of the neural networks underlying addictive processes. These experiments will explain how the positive rewarding and negative reinforcing aspects of alcohol are transduced within the brain. We believe that our research will facilitate the ability to treat alcoholism at a pharmacological level, enabling the continuation of abstinence or the prevention of relapse, while allowing other factors such as social support structure and coping skills to be developed for each individual, with flow-on social and economic benefits for society as a whole. Read moreRead less