Assuring the microbial safety and quality of Australian malt and barley. This project aims to ensure that Australian malt and barley is 'clean' and free of undesirable micro-organisms that may produce mycotoxins and factors that impact on brewing efficiency and beer quality. The project will determine what is the typical microbial composition and load of Australian malt and barley grown in different environments and areas benchmarked against malting barley and malt grown internationally. A set ....Assuring the microbial safety and quality of Australian malt and barley. This project aims to ensure that Australian malt and barley is 'clean' and free of undesirable micro-organisms that may produce mycotoxins and factors that impact on brewing efficiency and beer quality. The project will determine what is the typical microbial composition and load of Australian malt and barley grown in different environments and areas benchmarked against malting barley and malt grown internationally. A set of diagnostic tools are expected to be developed. The successful execution of the project is expected to highlight that Australian malt and barley is of high quality so that the health of domestic customers is ensured and it attracts a premium from our export customers.Read moreRead less
Investigation of the impact of malt haze active proteins to improve brewing efficiency and beer quality. Australia is a major world exporter of malting barley (~2 millon t/pa) and malt (600,000 t/pa), primarily to the rapidly expanding Asian economic development region. An additional 200,000 t/pa of malt is provided to the Australian domestic brewing industry. By improving the quality of Australian malting barley and optimising the cost of brewery colloidal stabilisation measures, we expect hi ....Investigation of the impact of malt haze active proteins to improve brewing efficiency and beer quality. Australia is a major world exporter of malting barley (~2 millon t/pa) and malt (600,000 t/pa), primarily to the rapidly expanding Asian economic development region. An additional 200,000 t/pa of malt is provided to the Australian domestic brewing industry. By improving the quality of Australian malting barley and optimising the cost of brewery colloidal stabilisation measures, we expect higher demand and prices for Australian malting barley and malt. This will help support the viability of rural communities and the value adding involved in the malting and brewing of their produce in Australia.Read moreRead less
Barley malt modification, its control by understanding the biochemistry and genetics of proteases and thioredoxin. Australia is a major world exporter of malting barley (~2 millon t/pa) and malt (800,000 t/pa), primarily to the rapidly expanding Asian economic development region. An additional 200,000 t/pa of malt is provided to the Australian domestic brewing industry. By improving the quality of Australian malting barley and optimising its production, we expect higher demand and prices for A ....Barley malt modification, its control by understanding the biochemistry and genetics of proteases and thioredoxin. Australia is a major world exporter of malting barley (~2 millon t/pa) and malt (800,000 t/pa), primarily to the rapidly expanding Asian economic development region. An additional 200,000 t/pa of malt is provided to the Australian domestic brewing industry. By improving the quality of Australian malting barley and optimising its production, we expect higher demand and prices for Australian malting barley and malt. This will help support the viability of rural communities and the value adding involved in the malting and brewing of their produce in Australia.Read moreRead less
The Future In Our Hands: Screening For Preclinical Alzheimer's Disease By Analysing Hand Movements
Funder
National Health and Medical Research Council
Funding Amount
$899,782.00
Summary
Alzheimer's disease (AD) starts damaging the brain 10-20 years before memory problems begin. By the time of diagnosis, it is hard to treat because the damage is so severe. We need a way to detect AD much earlier. We will develop a simple new computer test to detect early signs of AD by recording and analysing hand movements. Then people can start prevention earlier and scientists can research better treatments to improve people's quality of life and reduce the number of people with dementia.
Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
The Role Of Excitotoxicity In Mediating Distal Axonal Degneration In ALS
Funder
National Health and Medical Research Council
Funding Amount
$392,952.00
Summary
Amyotrophic lateral sclerosis (ALS), the major cause of motor neuron disease, is a devastating diseasse for which there is no cure. There have been significant advances in understanding the pathology of ALS yet we still don’t know what causes the dying back of spinal motor neurons. We have new evidence that suggests that ALS may, in part, be caused by excitotoxcity - or over stimulation - of neurons in the spinal cord. We will follow this lead using a range of cutting edge experimental models.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
From risk factor analysis to translation: multiple sclerosis and vitamin D deficiency. This research on multiple sclerosis will focus on its causes and lifestyle factors that affect it and will trial vitamin D supplementation as a treatment. Studies on vitamin D deficiency in healthy populations aim to develop new public health recommendations on sun exposure and vitamin D that balance risk of skin cancer against vitamin D deficiency.
A Genome-wide Association Scan To Identify Genetic Risk Factors For Sight Threatening Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$982,203.00
Summary
Diabetic eye disease is an important complication of diabetes that can lead to blindness. Very little is known about how diabetes causes eye disease, but genetics is known to play a role. We aim to identify genes that contribute to eye disease in diabetes patients. We will compare genes between patients with diabetes with and without severe diabetic eye disease using cutting edge genomic technology. We hope to be able to better predict risk of blindness and to move towards novel treatments.