Radiation and Ablation in Rapidly Expanding Flows. The aim of the project is to record the spectra of radiation from a region of rapidly expanding flow representative of the passage of the shock layer on a re-entry capsule from the windward to the leeward surfaces. The significance of this work is that it addresses a critical area of spacecraft where the uncertainties of our design techniques are of the order of 300 per cent in terms of surface heat transfer, and current vehicles have to use lar ....Radiation and Ablation in Rapidly Expanding Flows. The aim of the project is to record the spectra of radiation from a region of rapidly expanding flow representative of the passage of the shock layer on a re-entry capsule from the windward to the leeward surfaces. The significance of this work is that it addresses a critical area of spacecraft where the uncertainties of our design techniques are of the order of 300 per cent in terms of surface heat transfer, and current vehicles have to use large safety factors to ensure survivability. The outputs from the project will be a data base of radiative parameters which should enable accurate models of the flow to be developed, which is expected to facilitate the design of advanced spacecraft with greater safety and reliability, and with lower structural mass.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Next generation garbage collection: discovery, design, and development. This project aims to improve the performance of programming languages used by millions of Australians every day, such as Java, JavaScript and PHP by developing improved memory-management algorithms. These languages use what is referred to as “garbage collection” to ensure memory is managed without data loss, but do so conservatively and consequently cause performance challenges and energy overheads. This project expects to p ....Next generation garbage collection: discovery, design, and development. This project aims to improve the performance of programming languages used by millions of Australians every day, such as Java, JavaScript and PHP by developing improved memory-management algorithms. These languages use what is referred to as “garbage collection” to ensure memory is managed without data loss, but do so conservatively and consequently cause performance challenges and energy overheads. This project expects to provide these languages with improved memory-management algorithms, and provides researchers and industry with a framework for innovation. This project will enable safe software that is more efficient on today's hardware and able to exploit emerging hardware. This project should lead to better performance and energy savings for server applications, phones, watches, and smart appliances, while ensuring memory safety.Read moreRead less
Linear Formation Interferometry for Astrophysics and New Space Technologies. This project will prototype a new type of visible and infrared light interferometry: telescopes freely moving in a line 10s of metres in length and directing their light towards a central beam combiner. This is particularly well suited to sparse aperture optical interferometry from space, which can be used to resolve angular scales much finer than the world's largest monolithic telescopes. The ground based prototype wil ....Linear Formation Interferometry for Astrophysics and New Space Technologies. This project will prototype a new type of visible and infrared light interferometry: telescopes freely moving in a line 10s of metres in length and directing their light towards a central beam combiner. This is particularly well suited to sparse aperture optical interferometry from space, which can be used to resolve angular scales much finer than the world's largest monolithic telescopes. The ground based prototype will also be able to make a several key astrophysical observations of benchmark stars and stellar systems, including making precise polarimetric measurements of dust shells around bright stars.Read moreRead less
The epigenetic blueprint for T cell differentiation: a genomic view. A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, ....The epigenetic blueprint for T cell differentiation: a genomic view. A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, and the mechanisms indicative of effective immune cell differentiation will be identified. This proposal will provide insights into key mechanisms that result in reprogramming of immune cell function and memory and have implications for understanding general cellular differentiation.Read moreRead less
How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, ....How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.Read moreRead less
microRNAs and the control of T lymphocyte differentiation, function and malignant transformation. The molecular mechanism of the immune system is not completely understood. This project will investigate how transcription factors and microRNAs, two major types of regulatory molecules work together to control immune responses. The results from this research will assist in the design of better vaccination strategies and treat certain lymphomas.
Technologies for space based interferometry. This project aims to develop a new method for laser displacement measurements that will be uniquely suited for use in space. These measurements will enable gravitational measurements of unprecedented accuracy. Missions such as GRACE utilise gravitational observations to provide the distribution of melting polar ice, changes in sea levels, and quantitative estimates of ground water in the world’s food bowls. The technique will also allow space-based gr ....Technologies for space based interferometry. This project aims to develop a new method for laser displacement measurements that will be uniquely suited for use in space. These measurements will enable gravitational measurements of unprecedented accuracy. Missions such as GRACE utilise gravitational observations to provide the distribution of melting polar ice, changes in sea levels, and quantitative estimates of ground water in the world’s food bowls. The technique will also allow space-based gravitational wave detectors far simpler than previous proposals. The improved performance, inherent robustness and drastically reduced complexity will enable new classes of missions that would not otherwise be possible. Read moreRead less
GRACE follow-on: validation of measurements and initial results. This project aims to advance knowledge to quantify ongoing mass loss of Earth’s polar ice caps and glaciers, increases in sea level, and changes in continental water storage. The project expects to improve the capability to monitor changes on Earth using satellites and to enhance analysis by exploiting data from new instrumentation on the GRACE Follow-On space gravity mission, due for launch in 2018. Expected results aim to improve ....GRACE follow-on: validation of measurements and initial results. This project aims to advance knowledge to quantify ongoing mass loss of Earth’s polar ice caps and glaciers, increases in sea level, and changes in continental water storage. The project expects to improve the capability to monitor changes on Earth using satellites and to enhance analysis by exploiting data from new instrumentation on the GRACE Follow-On space gravity mission, due for launch in 2018. Expected results aim to improve computational tools and to develop expertise to analyse the new data. Other expected outcomes include reliable methods to monitor significant sea-level rise and associated societal and economic disruptions.Read moreRead less
The role of Roquin in microRNA function and decay. The aim of this study is to understand how microRNAs (newly discovered genetic components that control cell growth and survival) function and are regulated. The expected discoveries will help understand how common cancers including breast cancer and autoimmune diseases emerge, and will help develop cutting edge genetic technologies.