Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346895
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance ex ....A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance existing excellence in a range of areas. Finally, the laboratory will provide opportunities to: collaborate and consult with industry; train postgraduate students in instrumentation used at the cutting edge of chemical and biochemical sciences.Read moreRead less
The fate of dietary selenium in vivo; a direct approach to linking chemical form with biological activity. Dietary selenium supplementation has great potential as a preventative treatment for a range of human health conditions, including cancer, that widely affect the Australian population. However, the adverse effects of such treatments are not fully recognised. This project will increase our knowledge of how selenium compounds are stored and utilised in the body and relate the information to c ....The fate of dietary selenium in vivo; a direct approach to linking chemical form with biological activity. Dietary selenium supplementation has great potential as a preventative treatment for a range of human health conditions, including cancer, that widely affect the Australian population. However, the adverse effects of such treatments are not fully recognised. This project will increase our knowledge of how selenium compounds are stored and utilised in the body and relate the information to clinical observations regarding dietary intake of selenium and other compounds. The new understanding generated will delineate the conditions for safe intake, so that the beneficial effects associated with selenium supplementation may be harnessed more effectively.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989336
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are ....The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are critical for the competitiveness of Australian industry, national productivity and economic growth. This application seeks to provide a facility for multidisciplinary scientific development that will enhance academic-industrial collaboration. This will position SA research community for scientific breakthroughs that benefit the Australian community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668489
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
South Australian NMR Infrastructure Consortium. The proposed four pieces of NMR infrastructure will significantly enhance NMR facilities in South Australia. As a result, researchers from across the state will have access to a range of spectrometer field strengths to examine samples in the solution and solid phases. The infrastructure will support projects involving fundamental and strategic research spanning nanotechnology and the biological and materials sciences to industry-oriented projects. ....South Australian NMR Infrastructure Consortium. The proposed four pieces of NMR infrastructure will significantly enhance NMR facilities in South Australia. As a result, researchers from across the state will have access to a range of spectrometer field strengths to examine samples in the solution and solid phases. The infrastructure will support projects involving fundamental and strategic research spanning nanotechnology and the biological and materials sciences to industry-oriented projects. In addition, the proposal falls well within the South Australian state government's Science, Technology and Innovation plan for the next ten years to create and equip research precincts at various nodes within Adelaide.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989374
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility. The analytical facility will enhance (i) fundamental research to understand the mechanisms of the reactions of charged species with neutral molecules, and (ii) the provision of structural information, including the precise atomic composition of any molecule, small or large. Research supported by this facility includes (a)nanotechnology, including supramolecular chemistry, (b) bioscience: cancer research, neurodegenera ....South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility. The analytical facility will enhance (i) fundamental research to understand the mechanisms of the reactions of charged species with neutral molecules, and (ii) the provision of structural information, including the precise atomic composition of any molecule, small or large. Research supported by this facility includes (a)nanotechnology, including supramolecular chemistry, (b) bioscience: cancer research, neurodegenerate diseases (e.g. Parkinson's disease) osteoarthritis, inflammation, cardiac diseases and synthetic approaches to anticancer and other drugs.Read moreRead less
Gas Phase Reactivity of Charged Peptide and DNA Radicals: Fundamentals and Applications. Radicals derived from the "molecules of life", proteins and DNA, play both beneficial (e.g. enzyme catalysis) and deleterious roles (e.g. protein and DNA damage associated with disease). Two electrospray ionisation mass spectrometry approaches have been discovered to generate charged radicals of related models systems (e.g. peptides and nucleobases). The gas phase chemistry of these species is a largely unch ....Gas Phase Reactivity of Charged Peptide and DNA Radicals: Fundamentals and Applications. Radicals derived from the "molecules of life", proteins and DNA, play both beneficial (e.g. enzyme catalysis) and deleterious roles (e.g. protein and DNA damage associated with disease). Two electrospray ionisation mass spectrometry approaches have been discovered to generate charged radicals of related models systems (e.g. peptides and nucleobases). The gas phase chemistry of these species is a largely unchartered area! We will examine the fundamental chemistry (unimolecular and bimolecular reactions) of these systems and build upon some exciting preliminary results which suggest potential applications (e.g. as a proteomics tool to sequence and distinguish between leucine and isoleucine residues in peptides).Read moreRead less
Gas Phase Studies to Catalyze a Better Understanding of Metal Reactivity. The proposed research will increase knowledge of fundamental questions related to the mechanisms of catalysis and metal ion reactivity. The insights gained will be an important addition to the knowledge base of our culture, both nationally and in the wider international context. We note that research into the behaviour and design of catalysts is a burgeoning field which reflects the great importance of this area in the int ....Gas Phase Studies to Catalyze a Better Understanding of Metal Reactivity. The proposed research will increase knowledge of fundamental questions related to the mechanisms of catalysis and metal ion reactivity. The insights gained will be an important addition to the knowledge base of our culture, both nationally and in the wider international context. We note that research into the behaviour and design of catalysts is a burgeoning field which reflects the great importance of this area in the international scientific community. Our proposal will add to fundamental knowledge and may also result in practical applications. More importantly, we will train and equip talented young people with a spectrum of skills which will make them well placed to meet the demand for highly skilled professional scientists.Read moreRead less
Controlled Supramolecular Assembly in Aqueous Molecular and Macroscopic Systems. This project uses benign and mainly bio-degradable materials to produce hydrogels which are remarkable new materials containing at least ninety-eight percent water which may be made into films. Similar films are proving to be valuable in covering wounds, particularly serious burns, and in greatly improving wound healing and tissue growth. They may also be useful in new coating and aircraft de-icing technologies. The ....Controlled Supramolecular Assembly in Aqueous Molecular and Macroscopic Systems. This project uses benign and mainly bio-degradable materials to produce hydrogels which are remarkable new materials containing at least ninety-eight percent water which may be made into films. Similar films are proving to be valuable in covering wounds, particularly serious burns, and in greatly improving wound healing and tissue growth. They may also be useful in new coating and aircraft de-icing technologies. These environmentally friendly materials are likely to find a multitude of uses as their development progresses. Young Australians involved in the project will gain experience in cutting edge science, its practical applications, and in international collaboration - a training essential to Australia's future prosperity.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346733
Funder
Australian Research Council
Funding Amount
$399,466.00
Summary
Ultra-Sensitive CCD Diffractometer with High Intensity X-ray Photon Generator. X-ray photon diffraction from single crystals provides the most accurate, precise and detailed three dimensional chemical structure information. It is however often difficult to obtain crystals of complex chemical assemblies, such as those used in nanotechnology and photon technology, suitable for diffraction analysis using equipment currently available at Australian chemical crystal structure facilities. The collab ....Ultra-Sensitive CCD Diffractometer with High Intensity X-ray Photon Generator. X-ray photon diffraction from single crystals provides the most accurate, precise and detailed three dimensional chemical structure information. It is however often difficult to obtain crystals of complex chemical assemblies, such as those used in nanotechnology and photon technology, suitable for diffraction analysis using equipment currently available at Australian chemical crystal structure facilities. The collaborating institutions seek to overcome this problem by purchasing a high sensitivity CCD area detector coupled to an intense laboratory source of X-ray photons. The installation of the equipment would be the first of its kind at an Australian facility and only the fourth worldwide.Read moreRead less